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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes: From the published set of protein complexes.
Complex Size: 11 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
RAV1
  • RAVE complex
  • cytoplasm
  • extrinsic to membrane
    		•
  • early endosome to late endosome transport
  • regulation of protein complex assembly
  • vacuolar acidification
    		•
  • molecular_function
    		•
    TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • protein metabolic process
  • vacuolar acidification
  • intron homing
    		•
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
    		•
    VMA10
  • vacuolar proton-transporting V-type ATPase, V1 domain
    		•
  • glycogen metabolic process
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA13
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA2
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • cytoplasm
    		•
  • vacuolar acidification
  • cellular calcium ion homeostasis
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA4
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA5
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA6
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • vacuolar membrane
    		•
  • vacuolar transport
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA7
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA8
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VPH1
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • fungal-type vacuole membrane
    		•
  • protein complex assembly
  • vacuolar acidification
  • polyphosphate metabolic process
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    vacuolar proton-transporting V-type ATPase complex 1.2406E-27 11 15 10 6292
    proton-transporting V-type ATPase complex 1.2406E-27 11 15 10 6292
    proton-transporting V-type ATPase, V1 domain 2.7204E-24 11 8 8 6292
    vacuolar proton-transporting V-type ATPase, V1 domain 2.7204E-24 11 8 8 6292
    proton-transporting two-sector ATPase complex 7.5618E-23 11 35 10 6292
    proton-transporting two-sector ATPase complex, catalytic domain 3.4937E-21 11 13 8 6292
    vacuolar membrane 2.5285E-17 11 113 10 6292
    vacuolar part 5.1466E-17 11 121 10 6292
    vacuole 1.4139E-14 11 209 10 6292
    fungal-type vacuole membrane 7.4091E-12 11 74 7 6292
    membrane part 1.6229E-11 11 662 11 6292
    fungal-type vacuole 1.6735E-9 11 158 7 6292
    lytic vacuole 1.6735E-9 11 158 7 6292
    storage vacuole 1.6735E-9 11 158 7 6292
    organelle membrane 2.422E-9 11 692 10 6292
    protein complex 6.4478E-9 11 1137 11 6292
    membrane 1.1486E-8 11 1198 11 6292
    macromolecular complex 3.5578E-7 11 1635 11 6292
    cytoplasmic part 3.5506E-5 11 2482 11 6292
    vacuolar proton-transporting V-type ATPase, V0 domain 5.8081E-5 11 7 2 6292
    proton-transporting V-type ATPase, V0 domain 5.8081E-5 11 7 2 6292
    organelle part 2.8711E-4 11 2282 10 6292
    intracellular organelle part 2.8711E-4 11 2282 10 6292
    proton-transporting two-sector ATPase complex, proton-transporting domain 4.6756E-4 11 19 2 6292
    cytoplasm 1.8433E-3 11 3552 11 6292
    RAVE complex 5.2364E-3 11 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pH reduction 1.6427E-28 11 24 11 6292
    intracellular pH reduction 1.6427E-28 11 24 11 6292
    vacuolar acidification 1.6427E-28 11 24 11 6292
    regulation of intracellular pH 2.9333E-28 11 25 11 6292
    regulation of cellular pH 2.9333E-28 11 25 11 6292
    regulation of pH 2.2768E-27 11 29 11 6292
    cellular monovalent inorganic cation homeostasis 1.8828E-26 11 34 11 6292
    monovalent inorganic cation homeostasis 7.9188E-26 11 38 11 6292
    cellular cation homeostasis 1.6396E-20 11 105 11 6292
    cation homeostasis 2.5251E-20 11 109 11 6292
    cellular chemical homeostasis 6.938E-20 11 119 11 6292
    cellular ion homeostasis 6.938E-20 11 119 11 6292
    cellular homeostasis 7.6382E-20 11 120 11 6292
    chemical homeostasis 1.0142E-19 11 123 11 6292
    ion homeostasis 1.0142E-19 11 123 11 6292
    homeostatic process 7.5047E-14 11 408 11 6292
    regulation of biological quality 2.1191E-12 11 551 11 6292
    biological regulation 1.3178E-8 11 1213 11 6292
    early endosome to late endosome transport 1.7483E-3 11 1 1 6292
    polyphosphate metabolic process 5.2364E-3 11 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    proton-transporting ATPase activity, rotational mechanism 1.1818E-28 11 13 10 6292
    cation-transporting ATPase activity 3.3077E-27 11 16 10 6292
    ATPase activity, coupled to transmembrane movement of ions 8.2577E-24 11 29 10 6292
    hydrogen ion transmembrane transporter activity 9.8301E-21 11 54 10 6292
    primary active transmembrane transporter activity 1.2013E-20 11 55 10 6292
    P-P-bond-hydrolysis-driven transmembrane transporter activity 1.2013E-20 11 55 10 6292
    ATPase activity, coupled to transmembrane movement of substances 1.2013E-20 11 55 10 6292
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1.2013E-20 11 55 10 6292
    monovalent inorganic cation transmembrane transporter activity 2.5789E-20 11 59 10 6292
    ATPase activity, coupled to movement of substances 2.5789E-20 11 59 10 6292
    inorganic cation transmembrane transporter activity 7.838E-18 11 101 10 6292
    cation transmembrane transporter activity 3.9659E-17 11 118 10 6292
    active transmembrane transporter activity 5.1466E-17 11 121 10 6292
    ion transmembrane transporter activity 3.5863E-16 11 146 10 6292
    ATPase activity, coupled 4.4219E-16 11 149 10 6292
    ATPase activity 1.558E-14 11 211 10 6292
    substrate-specific transmembrane transporter activity 1.7029E-13 11 267 10 6292
    transmembrane transporter activity 6.7651E-13 11 306 10 6292
    nucleoside-triphosphatase activity 1.4063E-12 11 329 10 6292
    substrate-specific transporter activity 1.739E-12 11 336 10 6292
    hydrolase activity, acting on acid anhydrides 2.8601E-12 11 353 10 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.8601E-12 11 353 10 6292
    pyrophosphatase activity 2.8601E-12 11 353 10 6292
    transporter activity 1.1122E-11 11 404 10 6292
    hydrolase activity 3.7119E-8 11 911 10 6292
    catalytic activity 1.6253E-4 11 2150 10 6292
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