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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 4 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
DLS1
  • nucleus
  • chromatin accessibility complex
    		•
  • chromatin silencing at telomere
    		•
  • molecular_function
    		•
    ELA1
  • transcription elongation factor complex
  • Cul3-RING ubiquitin ligase complex
    		•
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • RNA elongation from RNA polymerase II promoter
    		•
  • transcription elongation regulator activity
    		•
    ISW2
  • nucleus
  • chromatin accessibility complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter by pheromones
  • chromatin remodeling
  • nucleosome positioning
  • chromatin silencing at telomere
    		•
  • ATPase activity
    		•
    ITC1
  • chromatin accessibility complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter by pheromones
  • chromatin remodeling
  • chromatin silencing at telomere
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    chromatin accessibility complex 3.8553E-10 4 4 3 6292
    chromatin remodeling complex 1.4946E-5 4 99 3 6292
    nuclear part 9.4015E-4 4 1103 4 6292
    protein complex 1.0617E-3 4 1137 4 6292
    Cul3-RING ubiquitin ligase complex 2.5411E-3 4 4 1 6292
    macromolecular complex 4.5471E-3 4 1635 4 6292
    cullin-RING ubiquitin ligase complex 8.8726E-3 4 14 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    negative regulation of transcription from RNA polymerase II promoter by pheromones 1.8182E-6 4 4 2 6292
    negative regulation of gene-specific transcription from RNA polymerase II promoter 1.8182E-6 4 4 2 6292
    negative regulation of gene-specific transcription 1.8182E-6 4 4 2 6292
    negative regulation of transcription by pheromones 1.8182E-6 4 4 2 6292
    chromatin silencing at telomere 2.5132E-6 4 55 3 6292
    gene-specific transcription from RNA polymerase II promoter 1.3619E-5 4 10 2 6292
    regulation of transcription by pheromones 1.3619E-5 4 10 2 6292
    regulation of transcription from RNA polymerase II promoter by pheromones 1.3619E-5 4 10 2 6292
    cellular response to pheromone 1.3619E-5 4 10 2 6292
    regulation of gene-specific transcription from RNA polymerase II promoter 1.3619E-5 4 10 2 6292
    negative regulation of gene expression, epigenetic 1.5407E-5 4 100 3 6292
    gene silencing 1.5407E-5 4 100 3 6292
    regulation of gene expression, epigenetic 1.5407E-5 4 100 3 6292
    chromatin silencing 1.5407E-5 4 100 3 6292
    regulation of gene-specific transcription 3.1744E-5 4 15 2 6292
    transcription, DNA-dependent 4.0396E-5 4 503 4 6292
    RNA biosynthetic process 4.2031E-5 4 508 4 6292
    cellular response to organic substance 5.7381E-5 4 20 2 6292
    transcription 5.8652E-5 4 552 4 6292
    negative regulation of transcription, DNA-dependent 5.987E-5 4 157 3 6292
    negative regulation of RNA metabolic process 6.1021E-5 4 158 3 6292
    negative regulation of transcription 6.8238E-5 4 164 3 6292
    negative regulation of gene expression 6.8238E-5 4 164 3 6292
    negative regulation of macromolecule biosynthetic process 8.2896E-5 4 175 3 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.0195E-5 4 180 3 6292
    negative regulation of nitrogen compound metabolic process 9.0195E-5 4 180 3 6292
    negative regulation of biosynthetic process 1.0438E-4 4 189 3 6292
    negative regulation of cellular biosynthetic process 1.0438E-4 4 189 3 6292
    negative regulation of macromolecule metabolic process 1.0942E-4 4 192 3 6292
    negative regulation of cellular metabolic process 1.4102E-4 4 209 3 6292
    negative regulation of metabolic process 1.4305E-4 4 210 3 6292
    negative regulation of cellular process 2.4072E-4 4 250 3 6292
    negative regulation of biological process 2.4943E-4 4 253 3 6292
    RNA metabolic process 5.2568E-4 4 954 4 6292
    negative regulation of transcription from RNA polymerase II promoter 5.3002E-4 4 60 2 6292
    transcription from RNA polymerase II promoter 5.749E-4 4 335 3 6292
    chromatin remodeling 6.8098E-4 4 68 2 6292
    regulation of transcription, DNA-dependent 7.0003E-4 4 358 3 6292
    regulation of RNA metabolic process 7.294E-4 4 363 3 6292
    regulation of transcription 8.6159E-4 4 384 3 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.084E-3 4 415 3 6292
    regulation of nitrogen compound metabolic process 1.0917E-3 4 416 3 6292
    cellular macromolecule biosynthetic process 1.2614E-3 4 1187 4 6292
    macromolecule biosynthetic process 1.27E-3 4 1189 4 6292
    regulation of gene expression 1.3321E-3 4 445 3 6292
    response to pheromone 1.3833E-3 4 97 2 6292
    regulation of macromolecule biosynthetic process 1.4316E-3 4 456 3 6292
    regulation of cellular biosynthetic process 1.5848E-3 4 472 3 6292
    regulation of biosynthetic process 1.5947E-3 4 473 3 6292
    cellular response to chemical stimulus 1.6812E-3 4 107 2 6292
    gene expression 1.7224E-3 4 1283 4 6292
    regulation of macromolecule metabolic process 1.7483E-3 4 488 3 6292
    nucleosome positioning 1.9063E-3 4 3 1 6292
    regulation of primary metabolic process 2.0368E-3 4 514 3 6292
    regulation of cellular metabolic process 2.3038E-3 4 536 3 6292
    regulation of metabolic process 2.4454E-3 4 547 3 6292
    nucleic acid metabolic process 2.5494E-3 4 1415 4 6292
    response to organic substance 2.7441E-3 4 137 2 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.8261E-3 4 1566 4 6292
    cellular biosynthetic process 3.8359E-3 4 1567 4 6292
    chromatin modification 4.1046E-3 4 168 2 6292
    biosynthetic process 4.1907E-3 4 1602 4 6292
    chromatin organization 5.954E-3 4 203 2 6292
    cellular nitrogen compound metabolic process 6.2471E-3 4 1770 4 6292
    nitrogen compound metabolic process 6.5492E-3 4 1791 4 6292
    protein ubiquitination during ubiquitin-dependent protein catabolic process 6.9763E-3 4 11 1 6292
    regulation of cellular process 7.309E-3 4 796 3 6292
    regulation of transcription from RNA polymerase II promoter 7.4744E-3 4 228 2 6292
    regulation of biological process 8.0789E-3 4 824 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle