YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 10 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
HAT1
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
    		•
  • histone acetylation
  • chromatin silencing at telomere
    		•
  • histone binding
    		•
    HAT2
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
    		•
  • chromatin assembly or disassembly
  • histone acetylation
  • chromatin silencing at telomere
    		•
  • histone binding
    		•
    ORC1
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • ATPase activity
  • DNA replication origin binding
    		•
    ORC2
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•
    ORC3
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•
    ORC4
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•
    ORC5
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • ATPase activity
  • DNA replication origin binding
    		•
    ORC6
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•
    SWE1
  • nucleus
  • cellular bud neck
    		•
  • cell morphogenesis checkpoint
  • G2/M transition size control checkpoint
  • G2/M transition of mitotic cell cycle
  • regulation of cell size
  • regulation of meiosis
  • regulation of cyclin-dependent protein kinase activity
    		•
  • protein kinase activity
    		•
    YJR154W
  • cytoplasm
    		•
  • biological_process
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    origin recognition complex 2.4426E-18 10 6 6 6292
    nuclear origin of replication recognition complex 2.4426E-18 10 6 6 6292
    pre-replicative complex 1.9454E-14 10 16 6 6292
    protein-DNA complex 8.6198E-11 10 57 6 6292
    nucleoplasm part 1.9879E-10 10 245 8 6292
    nucleoplasm 3.6235E-10 10 264 8 6292
    nuclear lumen 2.6926E-8 10 453 8 6292
    nuclear chromosome part 1.3314E-7 10 190 6 6292
    nuclear chromosome 3.9443E-7 10 228 6 6292
    chromosomal part 4.9632E-7 10 237 6 6292
    organelle lumen 5.2324E-7 10 660 8 6292
    intracellular organelle lumen 5.2324E-7 10 660 8 6292
    membrane-enclosed lumen 8.2941E-7 10 700 8 6292
    chromosome 1.1708E-6 10 274 6 6292
    nuclear part 2.8079E-5 10 1103 8 6292
    protein complex 3.542E-5 10 1137 8 6292
    nucleus 2.7855E-4 10 2041 9 6292
    macromolecular complex 5.4804E-4 10 1635 8 6292
    non-membrane-bounded organelle 1.4928E-3 10 959 6 6292
    intracellular non-membrane-bounded organelle 1.4928E-3 10 959 6 6292
    histone acetyltransferase complex 2.0756E-3 10 44 2 6292
    organelle part 6.1675E-3 10 2282 8 6292
    intracellular organelle part 6.1675E-3 10 2282 8 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pre-replicative complex assembly 4.1755E-15 10 13 6 6292
    negative regulation of gene expression, epigenetic 1.3449E-13 10 100 8 6292
    gene silencing 1.3449E-13 10 100 8 6292
    regulation of gene expression, epigenetic 1.3449E-13 10 100 8 6292
    chromatin silencing 1.3449E-13 10 100 8 6292
    DNA replication initiation 2.6657E-12 10 33 6 6292
    chromatin silencing at silent mating-type cassette 2.6657E-12 10 33 6 6292
    negative regulation of transcription, DNA-dependent 5.4302E-12 10 157 8 6292
    negative regulation of RNA metabolic process 5.7181E-12 10 158 8 6292
    negative regulation of transcription 7.7429E-12 10 164 8 6292
    negative regulation of gene expression 7.7429E-12 10 164 8 6292
    protein-DNA complex assembly 7.8268E-12 10 39 6 6292
    negative regulation of macromolecule biosynthetic process 1.3118E-11 10 175 8 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.6486E-11 10 180 8 6292
    negative regulation of nitrogen compound metabolic process 1.6486E-11 10 180 8 6292
    negative regulation of biosynthetic process 2.4479E-11 10 189 8 6292
    negative regulation of cellular biosynthetic process 2.4479E-11 10 189 8 6292
    negative regulation of macromolecule metabolic process 2.7808E-11 10 192 8 6292
    negative regulation of cellular metabolic process 5.5216E-11 10 209 8 6292
    negative regulation of metabolic process 5.7386E-11 10 210 8 6292
    negative regulation of cellular process 2.3387E-10 10 250 8 6292
    negative regulation of biological process 2.5741E-10 10 253 8 6292
    DNA-dependent DNA replication 8.2041E-10 10 82 6 6292
    regulation of cellular metabolic process 2.0533E-9 10 536 9 6292
    regulation of metabolic process 2.4644E-9 10 547 9 6292
    regulation of transcription, DNA-dependent 4.1457E-9 10 358 8 6292
    regulation of RNA metabolic process 4.6304E-9 10 363 8 6292
    regulation of transcription 7.2469E-9 10 384 8 6292
    DNA replication 9.7332E-9 10 123 6 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3436E-8 10 415 8 6292
    regulation of nitrogen compound metabolic process 1.3695E-8 10 416 8 6292
    regulation of gene expression 2.3379E-8 10 445 8 6292
    regulation of macromolecule biosynthetic process 2.8372E-8 10 456 8 6292
    regulation of cellular biosynthetic process 3.7284E-8 10 472 8 6292
    regulation of biosynthetic process 3.7914E-8 10 473 8 6292
    regulation of macromolecule metabolic process 4.854E-8 10 488 8 6292
    transcription, DNA-dependent 6.1668E-8 10 503 8 6292
    RNA biosynthetic process 6.6681E-8 10 508 8 6292
    regulation of cellular process 7.0786E-8 10 796 9 6292
    regulation of primary metabolic process 7.3162E-8 10 514 8 6292
    regulation of biological process 9.6334E-8 10 824 9 6292
    cellular macromolecular complex assembly 1.0295E-7 10 182 6 6292
    transcription 1.2844E-7 10 552 8 6292
    cellular macromolecular complex subunit organization 8.3957E-7 10 259 6 6292
    macromolecular complex assembly 1.3586E-6 10 281 6 6292
    biological regulation 2.9717E-6 10 1213 9 6292
    macromolecular complex subunit organization 5.5349E-6 10 357 6 6292
    cellular component assembly 8.5951E-6 10 385 6 6292
    RNA metabolic process 9.1999E-6 10 954 8 6292
    cellular component organization 3.0582E-5 10 1582 9 6292
    cellular macromolecule biosynthetic process 4.9194E-5 10 1187 8 6292
    macromolecule biosynthetic process 4.9829E-5 10 1189 8 6292
    gene expression 8.885E-5 10 1283 8 6292
    DNA metabolic process 9.5453E-5 10 585 6 6292
    nucleic acid metabolic process 1.8614E-4 10 1415 8 6292
    cellular component biogenesis 2.5043E-4 10 694 6 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.9771E-4 10 1566 8 6292
    cellular biosynthetic process 3.9961E-4 10 1567 8 6292
    biosynthetic process 4.7103E-4 10 1602 8 6292
    cellular nitrogen compound metabolic process 9.8474E-4 10 1770 8 6292
    nitrogen compound metabolic process 1.0739E-3 10 1791 8 6292
    histone acetylation 1.3917E-3 10 36 2 6292
    G2/M transition checkpoint 1.5893E-3 10 1 1 6292
    G2/M transition size control checkpoint 1.5893E-3 10 1 1 6292
    cell size control checkpoint 1.5893E-3 10 1 1 6292
    protein amino acid acetylation 2.267E-3 10 46 2 6292
    cell morphogenesis checkpoint 3.1764E-3 10 2 1 6292
    chromatin silencing at telomere 3.228E-3 10 55 2 6292
    protein amino acid acylation 3.7066E-3 10 59 2 6292
    cellular macromolecule metabolic process 6.225E-3 10 2285 8 6292
    macromolecule metabolic process 7.5629E-3 10 2349 8 6292
    cellular metabolic process 7.9165E-3 10 3033 9 6292
    covalent chromatin modification 8.0911E-3 10 88 2 6292
    histone modification 8.0911E-3 10 88 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    DNA replication origin binding 4.1755E-15 10 13 6 6292
    sequence-specific DNA binding 3.7892E-11 10 50 6 6292
    DNA binding 7.8367E-7 10 256 6 6292
    binding 9.4788E-5 10 1294 8 6292
    nucleic acid binding 1.9872E-4 10 666 6 6292
    histone binding 2.0481E-4 10 14 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle