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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC55
  • nucleus
  • cellular bud tip
  • cellular bud neck
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • negative regulation of exit from mitosis
  • protein amino acid dephosphorylation
  • pseudohyphal growth
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • protein phosphatase type 2A regulator activity
  • FIR1
  • cellular bud neck
  • RNA polyadenylation
  • mRNA polyadenylation
  • molecular_function
  • PHR1
  • nucleus
  • mitochondrion
  • photoreactive repair
  • deoxyribodipyrimidine photo-lyase activity
  • PPH21
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • PPH22
  • condensed nuclear chromosome, centromeric region
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • RRD2
  • cytosol
  • cell fraction
  • response to osmotic stress
  • mitotic spindle organization in nucleus
  • protein phosphatase type 2A regulator activity
  • TPD3
  • nucleus
  • cellular bud tip
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • mating projection tip
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • YRR1
  • nucleus
  • drug transmembrane transport
  • positive regulation of transcription from RNA polymerase II promoter
  • specific RNA polymerase II transcription factor activity
  • ZDS1
  • cellular bud tip
  • cytoplasm
  • cellular bud neck
  • nuclear pore
  • mRNA export from nucleus
  • chromatin silencing
  • cell aging
  • protein binding
  • ZDS2
  • nucleus
  • chromatin silencing at rDNA
  • cell aging
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein phosphatase type 2A complex 4.8208E-11 10 6 4 6292
    protein serine/threonine phosphatase complex 7.585E-9 10 17 4 6292
    cellular bud neck 3.2191E-5 10 129 4 6292
    cellular bud tip 8.0877E-5 10 57 3 6292
    cellular bud 8.6684E-5 10 166 4 6292
    site of polarized growth 9.0836E-5 10 168 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    negative regulation of nuclear division 1.9016E-8 10 21 4 6292
    negative regulation of mitotic metaphase/anaphase transition 1.9016E-8 10 21 4 6292
    mitotic cell cycle spindle assembly checkpoint 1.9016E-8 10 21 4 6292
    negative regulation of mitosis 1.9016E-8 10 21 4 6292
    spindle assembly checkpoint 1.9016E-8 10 21 4 6292
    negative regulation of cell cycle 2.3224E-8 10 22 4 6292
    spindle checkpoint 4.0069E-8 10 25 4 6292
    regulation of mitotic metaphase/anaphase transition 4.0069E-8 10 25 4 6292
    mitotic cell cycle spindle checkpoint 4.0069E-8 10 25 4 6292
    mitotic cell cycle checkpoint 6.4706E-8 10 28 4 6292
    protein amino acid dephosphorylation 6.4706E-8 10 28 4 6292
    regulation of nuclear division 7.5002E-8 10 29 4 6292
    negative regulation of organelle organization 7.5002E-8 10 29 4 6292
    negative regulation of cellular component organization 7.5002E-8 10 29 4 6292
    regulation of mitosis 7.5002E-8 10 29 4 6292
    negative regulation of cell cycle process 1.133E-7 10 32 4 6292
    budding cell bud growth 1.4589E-7 10 34 4 6292
    mitotic metaphase/anaphase transition 2.0728E-7 10 37 4 6292
    dephosphorylation 2.8617E-7 10 40 4 6292
    negative regulation of cellular process 6.8106E-7 10 250 6 6292
    negative regulation of biological process 7.3088E-7 10 253 6 6292
    regulation of organelle organization 8.3997E-7 10 52 4 6292
    cell cycle checkpoint 1.3103E-6 10 58 4 6292
    actin filament organization 2.4959E-6 10 68 4 6292
    regulation of mitotic cell cycle 2.971E-6 10 71 4 6292
    regulation of cellular component organization 3.7051E-6 10 75 4 6292
    regulation of cell cycle process 5.0482E-6 10 81 4 6292
    cell budding 7.6996E-6 10 90 4 6292
    asexual reproduction 7.6996E-6 10 90 4 6292
    mitosis 1.3707E-5 10 104 4 6292
    cytoskeleton organization 1.3847E-5 10 231 5 6292
    nuclear division 1.4786E-5 10 106 4 6292
    actin cytoskeleton organization 1.9061E-5 10 113 4 6292
    organelle fission 1.9061E-5 10 113 4 6292
    actin filament-based process 2.1879E-5 10 117 4 6292
    mitotic cell cycle 2.2422E-5 10 255 5 6292
    M phase of mitotic cell cycle 3.1217E-5 10 128 4 6292
    regulation of cell cycle 3.4206E-5 10 131 4 6292
    regulation of cellular process 4.2924E-5 10 796 7 6292
    M phase 4.4709E-5 10 294 5 6292
    cell division 5.102E-5 10 145 4 6292
    growth 5.102E-5 10 145 4 6292
    regulation of biological process 5.4013E-5 10 824 7 6292
    gene expression 8.885E-5 10 1283 8 6292
    cell cycle phase 1.4565E-4 10 376 5 6292
    signal transduction 2.3254E-4 10 214 4 6292
    signal transmission 2.4538E-4 10 217 4 6292
    signaling process 2.4538E-4 10 217 4 6292
    reproduction of a single-celled organism 2.4538E-4 10 217 4 6292
    phosphorus metabolic process 3.0194E-4 10 229 4 6292
    phosphate metabolic process 3.0194E-4 10 229 4 6292
    signaling 4.3593E-4 10 252 4 6292
    cell cycle process 5.0875E-4 10 490 5 6292
    cellular macromolecule biosynthetic process 5.882E-4 10 1187 7 6292
    macromolecule biosynthetic process 5.946E-4 10 1189 7 6292
    biological regulation 6.76E-4 10 1213 7 6292
    cell cycle 7.0181E-4 10 525 5 6292
    cellular macromolecule metabolic process 7.3309E-4 10 2285 9 6292
    macromolecule metabolic process 9.2762E-4 10 2349 9 6292
    reproduction 1.1852E-3 10 328 4 6292
    pyrimidine dimer repair 1.5893E-3 10 1 1 6292
    photoreactive repair 1.5893E-3 10 1 1 6292
    post-translational protein modification 1.628E-3 10 357 4 6292
    translation 1.975E-3 10 376 4 6292
    cell aging 2.5693E-3 10 49 2 6292
    G1/S transition of mitotic cell cycle 2.6741E-3 10 50 2 6292
    aging 2.7809E-3 10 51 2 6292
    cellular biosynthetic process 3.3987E-3 10 1567 7 6292
    biosynthetic process 3.8954E-3 10 1602 7 6292
    primary metabolic process 5.4001E-3 10 2896 9 6292
    protein modification process 5.5762E-3 10 499 4 6292
    negative regulation of exit from mitosis 6.3436E-3 10 4 1 6292
    cellular metabolic process 7.9165E-3 10 3033 9 6292
    macromolecule modification 8.9239E-3 10 569 4 6292
    interphase of mitotic cell cycle 9.7663E-3 10 97 2 6292
    interphase 9.7663E-3 10 97 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein serine/threonine phosphatase activity 7.3756E-6 10 26 3 6292
    protein phosphatase type 2A regulator activity 1.3619E-5 10 4 2 6292
    phosphoprotein phosphatase activity 3.4514E-5 10 43 3 6292
    phosphatase activity 2.8569E-4 10 87 3 6292
    phosphoric ester hydrolase activity 4.57E-4 10 102 3 6292
    protein phosphatase regulator activity 5.6509E-4 10 23 2 6292
    phosphatase regulator activity 5.6509E-4 10 23 2 6292
    deoxyribodipyrimidine photo-lyase activity 1.5893E-3 10 1 1 6292
    DNA photolyase activity 1.5893E-3 10 1 1 6292
    metal ion binding 3.228E-3 10 55 2 6292
    ion binding 3.3447E-3 10 56 2 6292
    cation binding 3.3447E-3 10 56 2 6292

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