YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 26 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AHA1
  • cytoplasm
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • BUD3
  • cellular bud neck contractile ring
  • cellular bud neck
  • axial cellular bud site selection
  • cellular bud site selection
  • cytokinesis
  • molecular_function
  • CNS1
  • cytoplasm
  • protein folding
  • Hsp90 protein binding
  • Hsp70 protein binding
  • CPR6
  • cytoplasm
  • protein folding
  • peptidyl-prolyl cis-trans isomerase activity
  • unfolded protein binding
  • DIG2
  • nucleus
  • invasive growth in response to glucose limitation
  • transcription factor binding
  • DNM1
  • mitochondrion
  • mitochondrial outer membrane
  • mitochondrion inheritance
  • protein homooligomerization
  • mitochondrion organization
  • mitochondrial fission
  • identical protein binding
  • protein homodimerization activity
  • GTPase activity
  • DSF1, YNR073C
  • cellular_component
  • biological_process
  • metabolic process
  • oxidation reduction
  • coenzyme binding
  • catalytic activity
  • oxidoreductase activity
  • mannitol dehydrogenase activity
  • binding
  • molecular_function
  • FRT2
  • endoplasmic reticulum
  • response to stress
  • molecular_function
  • GPA2
  • mitochondrion
  • plasma membrane
  • ascospore formation
  • signal transduction
  • regulation of cell size
  • pseudohyphal growth
  • replicative cell aging
  • GTPase activity
  • HOM6
  • nucleus
  • cytoplasm
  • response to drug
  • methionine metabolic process
  • threonine metabolic process
  • homoserine biosynthetic process
  • homoserine dehydrogenase activity
  • HSC82
  • cytoplasm
  • mitochondrion
  • telomere maintenance
  • protein folding
  • protein refolding
  • proteasome assembly
  • 'de novo' protein folding
  • response to stress
  • unfolded protein binding
  • ATPase activity, coupled
  • HSP104
  • nucleus
  • cytoplasm
  • telomere maintenance
  • chaperone mediated protein folding requiring cofactor
  • protein refolding
  • response to stress
  • chaperone binding
  • ATPase activity, coupled
  • HSP82
  • cytoplasm
  • response to osmotic stress
  • protein refolding
  • proteasome assembly
  • 'de novo' protein folding
  • response to stress
  • unfolded protein binding
  • ATPase activity, coupled
  • MBB1
    MRPL50
  • mitochondrion
  • mitochondrial large ribosomal subunit
  • translation
  • structural constituent of ribosome
  • PAM1
  • cellular bud
  • cellular bud neck
  • pseudohyphal growth
  • molecular_function
  • PPT1
  • nucleus
  • cytoplasm
  • protein amino acid dephosphorylation
  • ribosome biogenesis
  • protein serine/threonine phosphatase activity
  • QNS1
  • nucleus
  • cytoplasm
  • NAD biosynthetic process
  • NAD+ synthase (glutamine-hydrolyzing) activity
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
  • RMD8
  • cytoplasm
  • response to drug
  • molecular_function
  • RTS1
  • nucleus
  • condensed nuclear chromosome, centromeric region
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • protein phosphatase type 2A complex
  • protein amino acid dephosphorylation
  • meiotic sister chromatid cohesion, centromeric
  • translation
  • protein serine/threonine phosphatase activity
  • protein phosphatase type 2A regulator activity
  • SMT3
  • nucleus
  • septin ring
  • protein sumoylation
  • protein tag
  • STI1
  • cytoplasm
  • protein folding
  • chaperone inhibitor activity
  • chaperone activator activity
  • Hsp90 protein binding
  • Hsp70 protein binding
  • STP4
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • TDH1
  • lipid particle
  • fungal-type cell wall
  • cytoplasm
  • mitochondrion
  • gluconeogenesis
  • glycolysis
  • glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
  • UTP20
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA processing
  • snoRNA binding
  • YBL104C
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoplasm 2.3047E-3 26 3552 22 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein folding 1.8639E-8 26 78 7 6292
    'de novo' protein folding 5.1771E-6 26 9 3 6292
    protein refolding 7.3756E-6 26 10 3 6292
    proteasome assembly 2.4382E-4 26 6 2 6292
    cellular protein metabolic process 2.1696E-3 26 1074 11 6292
    protein metabolic process 3.446E-3 26 1136 11 6292
    'de novo' posttranslational protein folding 4.1322E-3 26 1 1 6292
    chaperone mediated protein folding requiring cofactor 4.1322E-3 26 1 1 6292
    meiotic sister chromatid cohesion, centromeric 4.1322E-3 26 1 1 6292
    protein homooligomerization 4.1322E-3 26 1 1 6292
    protein oligomerization 4.1322E-3 26 1 1 6292
    chaperone-mediated protein folding 4.1322E-3 26 1 1 6292
    filamentous growth of a population of unicellular organisms 5.8E-3 26 90 3 6292
    growth of unicellular organism as a thread of attached cells 5.8E-3 26 90 3 6292
    protein amino acid dephosphorylation 5.8105E-3 26 28 2 6292
    meiotic sister chromatid cohesion 8.248E-3 26 2 1 6292
    filamentous growth 9.1175E-3 26 106 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Hsp70 protein binding 1.6421E-5 26 2 2 6292
    Hsp90 protein binding 1.6421E-5 26 2 2 6292
    chaperone activator activity 4.9138E-5 26 3 2 6292
    heat shock protein binding 4.9138E-5 26 3 2 6292
    protein binding 5.0265E-4 26 612 9 6292
    chaperone binding 1.4494E-3 26 14 2 6292
    unfolded protein binding 1.9234E-3 26 61 3 6292
    chaperone inhibitor activity 4.1322E-3 26 1 1 6292
    mannitol dehydrogenase activity 4.1322E-3 26 1 1 6292
    homoserine dehydrogenase activity 4.1322E-3 26 1 1 6292
    NAD+ synthase (glutamine-hydrolyzing) activity 4.1322E-3 26 1 1 6292
    protein serine/threonine phosphatase activity 5.0211E-3 26 26 2 6292
    protein homodimerization activity 8.248E-3 26 2 1 6292
    hexitol dehydrogenase activity 8.248E-3 26 2 1 6292
    binding 9.6624E-3 26 1294 11 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle