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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 480.20
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AME1
  • COMA complex
  • spindle pole body
  • kinetochore
  • attachment of spindle microtubules to kinetochore
  • molecular_function
  • ARP1
  • dynactin complex
  • establishment of mitotic spindle orientation
  • nuclear migration
  • structural constituent of cytoskeleton
  • BIK1
  • spindle microtubule
  • cell cortex
  • spindle pole body
  • spindle
  • condensed nuclear chromosome kinetochore
  • kinetochore
  • mitotic spindle elongation
  • mitotic anaphase B
  • mitotic spindle organization in nucleus
  • karyogamy involved in conjugation with cellular fusion
  • microtubule binding
  • CIK1
  • spindle pole body
  • spindle
  • kinesin complex
  • cytoplasmic microtubule
  • establishment of mitotic spindle orientation
  • mitotic sister chromatid segregation
  • mitotic spindle organization in nucleus
  • karyogamy involved in conjugation with cellular fusion
  • meiosis
  • microtubule motor activity
  • DYN1
  • cytoplasmic dynein complex
  • cytoplasmic microtubule
  • mitotic spindle elongation
  • establishment of mitotic spindle orientation
  • mitotic sister chromatid segregation
  • nuclear migration along microtubule
  • motor activity
  • JNM1
  • dynactin complex
  • nuclear migration
  • structural constituent of cytoskeleton
  • KAR3
  • spindle pole body
  • microtubule
  • mitotic sister chromatid cohesion
  • mitosis
  • karyogamy involved in conjugation with cellular fusion
  • meiosis
  • microtubule motor activity
  • motor activity
  • KAR5
  • endoplasmic reticulum membrane
  • mitochondrion
  • karyogamy involved in conjugation with cellular fusion
  • molecular_function
  • NUF2
  • spindle microtubule
  • condensed nuclear chromosome, centromeric region
  • Ndc80 complex
  • spindle pole body
  • condensed nuclear chromosome kinetochore
  • microtubule nucleation
  • chromosome segregation
  • structural constituent of cytoskeleton
  • SPC19
  • spindle microtubule
  • DASH complex
  • spindle pole body
  • spindle
  • condensed nuclear chromosome kinetochore
  • microtubule nucleation
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • structural constituent of cytoskeleton
  • SPC34
  • spindle microtubule
  • DASH complex
  • spindle pole body
  • spindle
  • condensed nuclear chromosome kinetochore
  • microtubule nucleation
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • structural constituent of cytoskeleton
  • STU1
  • spindle pole body
  • microtubule nucleation
  • structural constituent of cytoskeleton
  • STU2
  • spindle microtubule
  • cell cortex
  • spindle pole body
  • condensed nuclear chromosome kinetochore
  • kinetochore
  • microtubule nucleation
  • mitotic spindle organization in nucleus
  • structural constituent of cytoskeleton
  • microtubule binding
  • TID3
  • condensed nuclear chromosome, centromeric region
  • Ndc80 complex
  • condensed nuclear chromosome kinetochore
  • microtubule nucleation
  • chromosome segregation
  • structural constituent of cytoskeleton
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    microtubule cytoskeleton 2.4489E-20 14 106 12 6292
    cytoskeletal part 7.0245E-17 14 201 12 6292
    cytoskeleton 1.6983E-16 14 216 12 6292
    microtubule 3.8301E-16 14 31 8 6292
    microtubule organizing center 1.0762E-15 14 63 9 6292
    spindle pole body 1.0762E-15 14 63 9 6292
    spindle pole 2.2328E-15 14 68 9 6292
    spindle 2.8365E-14 14 89 9 6292
    condensed nuclear chromosome kinetochore 3.665E-12 14 49 7 6292
    condensed chromosome kinetochore 3.665E-12 14 49 7 6292
    condensed chromosome, centromeric region 8.6072E-12 14 55 7 6292
    condensed nuclear chromosome, centromeric region 8.6072E-12 14 55 7 6292
    kinetochore 1.6301E-11 14 60 7 6292
    chromosome, centromeric region 3.6454E-11 14 67 7 6292
    spindle microtubule 1.4884E-10 14 17 5 6292
    condensed nuclear chromosome 2.2107E-10 14 86 7 6292
    non-membrane-bounded organelle 2.6914E-10 14 959 13 6292
    intracellular non-membrane-bounded organelle 2.6914E-10 14 959 13 6292
    condensed chromosome 4.1782E-10 14 94 7 6292
    microtubule associated complex 4.6119E-8 14 18 4 6292
    nuclear chromosome part 5.8858E-8 14 190 7 6292
    protein complex 7.3291E-8 14 1137 12 6292
    nuclear chromosome 2.0689E-7 14 228 7 6292
    chromosomal part 2.6981E-7 14 237 7 6292
    intracellular organelle part 6.6422E-7 14 2282 14 6292
    organelle part 6.6422E-7 14 2282 14 6292
    chromosome 7.2642E-7 14 274 7 6292
    macromolecular complex 4.856E-6 14 1635 12 6292
    dynactin complex 2.7517E-5 14 4 2 6292
    Ndc80 complex 2.7517E-5 14 4 2 6292
    DASH complex 2.9963E-4 14 12 2 6292
    cytoplasmic microtubule 4.1207E-4 14 14 2 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292
    cytoplasmic part 3.4004E-3 14 2482 11 6292
    nuclear part 5.4526E-3 14 1103 7 6292
    cytoplasmic dynein complex 8.8726E-3 14 4 1 6292
    dynein complex 8.8726E-3 14 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    microtubule cytoskeleton organization 2.2941E-18 14 97 11 6292
    microtubule-based process 1.0847E-17 14 111 11 6292
    cytoskeleton organization 4.2701E-14 14 231 11 6292
    microtubule nucleation 3.4611E-12 14 23 6 6292
    mitotic spindle organization 4.0939E-10 14 48 6 6292
    spindle organization 4.66E-10 14 49 6 6292
    mitotic spindle organization in nucleus 1.5653E-9 14 26 5 6292
    organelle organization 2.1574E-9 14 1127 13 6292
    mitotic cell cycle 1.5876E-8 14 255 8 6292
    karyogamy involved in conjugation with cellular fusion 4.6119E-8 14 18 4 6292
    karyogamy 4.6119E-8 14 18 4 6292
    chromosome segregation 1.6567E-7 14 128 6 6292
    cellular component organization 1.6627E-7 14 1582 13 6292
    establishment of spindle localization 1.043E-6 14 10 3 6292
    establishment of spindle orientation 1.043E-6 14 10 3 6292
    establishment of mitotic spindle localization 1.043E-6 14 10 3 6292
    spindle localization 1.043E-6 14 10 3 6292
    establishment of mitotic spindle orientation 1.043E-6 14 10 3 6292
    M phase 1.1719E-6 14 294 7 6292
    cell cycle process 2.5245E-6 14 490 8 6292
    cell cycle 4.2632E-6 14 525 8 6292
    organelle fusion 4.5524E-6 14 54 4 6292
    establishment of organelle localization 4.9032E-6 14 55 4 6292
    nucleus organization 5.2736E-6 14 56 4 6292
    cell cycle phase 6.1295E-6 14 376 7 6292
    nuclear migration 9.7792E-6 14 20 3 6292
    nucleus localization 9.7792E-6 14 20 3 6292
    establishment of nucleus localization 9.7792E-6 14 20 3 6292
    organelle localization 2.8013E-5 14 85 4 6292
    mitosis 6.2084E-5 14 104 4 6292
    nuclear division 6.6902E-5 14 106 4 6292
    organelle fission 8.5938E-5 14 113 4 6292
    conjugation with cellular fusion 1.2737E-4 14 125 4 6292
    conjugation 1.3138E-4 14 126 4 6292
    M phase of mitotic cell cycle 1.3967E-4 14 128 4 6292
    multi-organism process 2.1448E-4 14 143 4 6292
    mitotic sister chromatid segregation 3.6951E-4 14 66 3 6292
    sister chromatid segregation 4.2141E-4 14 69 3 6292
    regulation of microtubule polymerization or depolymerization 6.135E-4 14 17 2 6292
    regulation of microtubule-based process 6.135E-4 14 17 2 6292
    regulation of microtubule cytoskeleton organization 6.135E-4 14 17 2 6292
    microtubule polymerization or depolymerization 6.8931E-4 14 18 2 6292
    establishment of cell polarity 7.5139E-4 14 84 3 6292
    establishment or maintenance of cell polarity 7.7786E-4 14 85 3 6292
    regulation of cytoskeleton organization 8.5383E-4 14 20 2 6292
    mitotic spindle elongation 9.4251E-4 14 21 2 6292
    spindle elongation 9.4251E-4 14 21 2 6292
    reproductive cellular process 9.4413E-4 14 211 4 6292
    reproductive process 9.6104E-4 14 212 4 6292
    sexual reproduction 1.3682E-3 14 233 4 6292
    cell morphogenesis 2.3739E-3 14 125 3 6292
    cellular component morphogenesis 3.1472E-3 14 138 3 6292
    reproduction 4.7845E-3 14 328 4 6292
    regulation of organelle organization 5.7214E-3 14 52 2 6292
    microtubule anchoring 6.6614E-3 14 3 1 6292
    attachment of spindle microtubules to chromosome 6.6614E-3 14 3 1 6292
    attachment of spindle microtubules to kinetochore 6.6614E-3 14 3 1 6292
    cellular process 7.2188E-3 14 4426 14 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of cytoskeleton 4.2233E-14 14 53 8 6292
    structural molecule activity 1.4786E-7 14 339 8 6292
    motor activity 7.0183E-6 14 18 3 6292
    microtubule binding 2.0481E-4 14 10 2 6292
    microtubule motor activity 2.0481E-4 14 10 2 6292
    tubulin binding 8.5383E-4 14 20 2 6292
    cytoskeletal protein binding 7.3172E-3 14 59 2 6292

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