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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 220
Complex Size: 14 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CUP5
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • integral to membrane
    		•
  • cellular iron ion homeostasis
  • cellular copper ion homeostasis
  • proton transport
  • vacuole organization
  • vacuolar acidification
  • endocytosis
  • protein targeting to vacuole
    		•
  • hydrogen ion transmembrane transporter activity
    		•
    PPA1
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • integral to membrane
    		•
  • response to drug
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    STV1
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • late endosome
  • Golgi apparatus
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • protein metabolic process
  • vacuolar acidification
  • intron homing
    		•
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
    		•
    TFP3
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • integral to membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA10
  • vacuolar proton-transporting V-type ATPase, V1 domain
    		•
  • glycogen metabolic process
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA13
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA2
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • cytoplasm
    		•
  • vacuolar acidification
  • cellular calcium ion homeostasis
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA4
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA5
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA6
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • vacuolar membrane
    		•
  • vacuolar transport
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA7
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA8
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VPH1
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • fungal-type vacuole membrane
    		•
  • protein complex assembly
  • vacuolar acidification
  • polyphosphate metabolic process
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    vacuolar proton-transporting V-type ATPase complex 8.7045E-42 14 15 14 6292
    proton-transporting V-type ATPase complex 8.7045E-42 14 15 14 6292
    proton-transporting two-sector ATPase complex 1.3463E-33 14 35 14 6292
    vacuolar membrane 1.5914E-25 14 113 14 6292
    vacuolar part 4.3929E-25 14 121 14 6292
    proton-transporting V-type ATPase, V1 domain 4.9511E-23 14 8 8 6292
    vacuolar proton-transporting V-type ATPase, V1 domain 4.9511E-23 14 8 8 6292
    vacuole 1.2942E-21 14 209 14 6292
    proton-transporting two-sector ATPase complex, catalytic domain 6.345E-20 14 13 8 6292
    vacuolar proton-transporting V-type ATPase, V0 domain 2.4424E-16 14 7 6 6292
    proton-transporting V-type ATPase, V0 domain 2.4424E-16 14 7 6 6292
    membrane part 1.7995E-14 14 662 14 6292
    organelle membrane 3.367E-14 14 692 14 6292
    proton-transporting two-sector ATPase complex, proton-transporting domain 9.3434E-13 14 19 6 6292
    protein complex 3.7067E-11 14 1137 14 6292
    fungal-type vacuole membrane 7.4918E-11 14 74 7 6292
    membrane 7.7362E-11 14 1198 14 6292
    macromolecular complex 6.1412E-9 14 1635 14 6292
    fungal-type vacuole 1.633E-8 14 158 7 6292
    lytic vacuole 1.633E-8 14 158 7 6292
    storage vacuole 1.633E-8 14 158 7 6292
    organelle part 6.6422E-7 14 2282 14 6292
    intracellular organelle part 6.6422E-7 14 2282 14 6292
    cytoplasmic part 2.1603E-6 14 2482 14 6292
    cytoplasm 3.3016E-4 14 3552 14 6292
    membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pH reduction 1.1381E-36 14 24 14 6292
    intracellular pH reduction 1.1381E-36 14 24 14 6292
    vacuolar acidification 1.1381E-36 14 24 14 6292
    regulation of cellular pH 2.5866E-36 14 25 14 6292
    regulation of intracellular pH 2.5866E-36 14 25 14 6292
    regulation of pH 4.5007E-35 14 29 14 6292
    cellular monovalent inorganic cation homeostasis 8.0776E-34 14 34 14 6292
    monovalent inorganic cation homeostasis 5.6112E-33 14 38 14 6292
    cellular cation homeostasis 5.3242E-26 14 105 14 6292
    cation homeostasis 9.304E-26 14 109 14 6292
    cellular chemical homeostasis 3.4314E-25 14 119 14 6292
    cellular ion homeostasis 3.4314E-25 14 119 14 6292
    cellular homeostasis 3.8846E-25 14 120 14 6292
    chemical homeostasis 5.5997E-25 14 123 14 6292
    ion homeostasis 5.5997E-25 14 123 14 6292
    homeostatic process 1.8816E-17 14 408 14 6292
    regulation of biological quality 1.3398E-15 14 551 14 6292
    biological regulation 9.2171E-11 14 1213 14 6292
    polyphosphate metabolic process 6.6614E-3 14 3 1 6292
    cellular process 7.2188E-3 14 4426 14 6292
    di-, tri-valent inorganic cation homeostasis 9.0921E-3 14 66 2 6292
    cellular di-, tri-valent inorganic cation homeostasis 9.0921E-3 14 66 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    proton-transporting ATPase activity, rotational mechanism 3.6437E-39 14 13 13 6292
    cation-transporting ATPase activity 2.0396E-36 14 16 13 6292
    ATPase activity, coupled to transmembrane movement of ions 2.4669E-31 14 29 13 6292
    hydrogen ion transmembrane transporter activity 1.8833E-30 14 54 14 6292
    monovalent inorganic cation transmembrane transporter activity 7.7171E-30 14 59 14 6292
    primary active transmembrane transporter activity 5.2548E-27 14 55 13 6292
    P-P-bond-hydrolysis-driven transmembrane transporter activity 5.2548E-27 14 55 13 6292
    ATPase activity, coupled to transmembrane movement of substances 5.2548E-27 14 55 13 6292
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.2548E-27 14 55 13 6292
    ATPase activity, coupled to movement of substances 1.4647E-26 14 59 13 6292
    inorganic cation transmembrane transporter activity 2.9768E-26 14 101 14 6292
    cation transmembrane transporter activity 3.0277E-25 14 118 14 6292
    ion transmembrane transporter activity 6.9943E-24 14 146 14 6292
    active transmembrane transporter activity 3.5184E-22 14 121 13 6292
    ATPase activity, coupled 5.9686E-21 14 149 13 6292
    substrate-specific transmembrane transporter activity 4.4038E-20 14 267 14 6292
    transmembrane transporter activity 3.1063E-19 14 306 14 6292
    ATPase activity 6.4005E-19 14 211 13 6292
    substrate-specific transporter activity 1.1824E-18 14 336 14 6292
    transporter activity 1.6355E-17 14 404 14 6292
    nucleoside-triphosphatase activity 2.3213E-16 14 329 13 6292
    hydrolase activity, acting on acid anhydrides 5.8724E-16 14 353 13 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 5.8724E-16 14 353 13 6292
    pyrophosphatase activity 5.8724E-16 14 353 13 6292
    hydrolase activity 1.386E-10 14 911 13 6292
    catalytic activity 8.0949E-6 14 2150 13 6292
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