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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SEC18
  • cytoplasm
  • extrinsic to plasma membrane
  • vacuole inheritance
  • ER to Golgi vesicle-mediated transport
  • vacuole fusion, non-autophagic
  • ATPase activity
  • UBP6
  • proteasome regulatory particle
  • protein deubiquitination
  • ubiquitin-specific protease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 1.4714E-41 17 23 16 6292
    proteasome regulatory particle 1.4714E-41 17 23 16 6292
    proteasome complex 1.3482E-34 17 48 16 6292
    proteasome regulatory particle, base subcomplex 3.6026E-21 17 9 8 6292
    proteasome regulatory particle, lid subcomplex 3.0102E-17 17 10 7 6292
    protein complex 1.6761E-11 17 1137 16 6292
    macromolecular complex 5.268E-9 17 1635 16 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    modification-dependent protein catabolic process 5.4391E-23 17 156 15 6292
    ubiquitin-dependent protein catabolic process 5.4391E-23 17 156 15 6292
    proteolysis involved in cellular protein catabolic process 7.3299E-23 17 159 15 6292
    modification-dependent macromolecule catabolic process 1.1897E-22 17 164 15 6292
    cellular protein catabolic process 2.285E-22 17 171 15 6292
    proteolysis 9.9895E-22 17 188 15 6292
    protein catabolic process 1.0847E-21 17 189 15 6292
    cellular macromolecule catabolic process 1.992E-19 17 265 15 6292
    macromolecule catabolic process 9.7607E-19 17 294 15 6292
    cellular catabolic process 1.8408E-16 17 415 15 6292
    catabolic process 2.7139E-15 17 496 15 6292
    cellular protein metabolic process 6.767E-12 17 1074 16 6292
    protein metabolic process 1.6528E-11 17 1136 16 6292
    cellular macromolecule metabolic process 9.9267E-7 17 2285 16 6292
    macromolecule metabolic process 1.5241E-6 17 2349 16 6292
    primary metabolic process 3.8308E-5 17 2896 16 6292
    cellular metabolic process 7.7499E-5 17 3033 16 6292
    metabolic process 1.4236E-4 17 3157 16 6292
    cellular process 2.5051E-3 17 4426 17 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 1.6726E-17 17 54 10 6292
    peptidase activity, acting on L-amino acid peptides 5.9057E-17 17 95 11 6292
    peptidase activity 1.6964E-13 17 192 11 6292
    hydrolase activity 2.4324E-7 17 911 12 6292
    ATPase activity 1.2031E-5 17 211 6 6292
    nucleoside-triphosphatase activity 1.4788E-4 17 329 6 6292
    hydrolase activity, acting on acid anhydrides 2.1803E-4 17 353 6 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.1803E-4 17 353 6 6292
    pyrophosphatase activity 2.1803E-4 17 353 6 6292
    protein binding, bridging 1.2688E-3 17 20 2 6292
    catalytic activity 2.3594E-3 17 2150 12 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle