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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 13 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
    		•
  • ATP-dependent RNA helicase activity
    		•
    CLF1
  • chromatin
    		•
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
    		•
  • protein binding
    		•
    HSH155
  • U2 snRNP
    		•
  • spliceosome assembly
    		•
  • mRNA binding
    		•
    LEA1
  • cytoplasm
  • U2 snRNP
    		•
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
    		•
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
    		•
    PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
    		•
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
    		•
  • ATP-dependent RNA helicase activity
    		•
    PRP46
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
    		•
  • U5 snRNA binding
    		•
    RSE1
  • U2 snRNP
    		•
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
    		•
  • U2 snRNA binding
    		•
    SNT309
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • protein binding
    		•
    SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
    		•
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
    		•
    SPP382
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    STO1
  • commitment complex
  • nuclear cap binding complex
    		•
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    ribonucleoprotein complex 9.4432E-13 13 514 12 6292
    spliceosomal complex 1.5662E-10 13 45 6 6292
    small nuclear ribonucleoprotein complex 1.2841E-9 13 63 6 6292
    nuclear part 8.749E-9 13 1103 12 6292
    macromolecular complex 9.1057E-7 13 1635 12 6292
    organelle part 1.8381E-6 13 2282 13 6292
    intracellular organelle part 1.8381E-6 13 2282 13 6292
    U2 snRNP 1.9478E-6 13 13 3 6292
    U5 snRNP 2.476E-6 13 14 3 6292
    nucleus 1.2114E-5 13 2041 12 6292
    U4/U6 x U5 tri-snRNP complex 3.3022E-5 13 32 3 6292
    intracellular organelle 3.4477E-3 13 4070 13 6292
    organelle 3.4587E-3 13 4071 13 6292
    nuclear cap binding complex 6.1865E-3 13 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nuclear mRNA splicing, via spliceosome 1.4915E-21 13 99 12 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.6947E-21 13 100 12 6292
    RNA splicing, via transesterification reactions 3.9949E-21 13 107 12 6292
    RNA splicing 5.6034E-20 13 132 12 6292
    mRNA processing 4.4959E-19 13 156 12 6292
    mRNA metabolic process 2.1062E-17 13 213 12 6292
    RNA processing 1.17E-16 13 380 13 6292
    RNA metabolic process 2.0874E-11 13 954 13 6292
    gene expression 1.0037E-9 13 1283 13 6292
    nucleic acid metabolic process 3.6054E-9 13 1415 13 6292
    ribonucleoprotein complex assembly 1.3105E-8 13 92 6 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3544E-8 13 1566 13 6292
    spliceosome assembly 3.3001E-8 13 18 4 6292
    cellular nitrogen compound metabolic process 6.6927E-8 13 1770 13 6292
    nitrogen compound metabolic process 7.8058E-8 13 1791 13 6292
    cellular macromolecular complex assembly 7.8222E-7 13 182 6 6292
    cellular macromolecule metabolic process 1.8698E-6 13 2285 13 6292
    macromolecule metabolic process 2.6802E-6 13 2349 13 6292
    ribonucleoprotein complex biogenesis 3.1161E-6 13 374 7 6292
    cellular macromolecular complex subunit organization 6.1767E-6 13 259 6 6292
    macromolecular complex assembly 9.9032E-6 13 281 6 6292
    macromolecular complex subunit organization 3.9067E-5 13 357 6 6292
    primary metabolic process 4.1002E-5 13 2896 13 6292
    cellular component assembly 5.9948E-5 13 385 6 6292
    cellular metabolic process 7.4867E-5 13 3033 13 6292
    metabolic process 1.2617E-4 13 3157 13 6292
    spliceosomal conformational changes to generate catalytic conformation 1.4073E-4 13 9 2 6292
    cellular component biogenesis 1.8193E-4 13 694 7 6292
    regulation of hormone levels 2.0661E-3 13 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.0661E-3 13 1 1 6292
    auxin biosynthetic process 2.0661E-3 13 1 1 6292
    auxin metabolic process 2.0661E-3 13 1 1 6292
    hormone metabolic process 2.0661E-3 13 1 1 6292
    hormone biosynthetic process 2.0661E-3 13 1 1 6292
    nuclear mRNA 3'-splice site recognition 4.1283E-3 13 2 1 6292
    cis assembly of pre-catalytic spliceosome 4.1283E-3 13 2 1 6292
    cellular component organization 5.8173E-3 13 1582 8 6292
    nuclear mRNA cis splicing, via spliceosome 6.1865E-3 13 3 1 6292
    generation of catalytic spliceosome for first transesterification step 6.1865E-3 13 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    snRNA binding 6.8758E-8 13 5 3 6292
    RNA binding 1.2363E-7 13 367 8 6292
    U5 snRNA binding 3.9411E-6 13 2 2 6292
    nucleic acid binding 1.1996E-5 13 666 8 6292
    binding 2.0347E-5 13 1294 10 6292
    ATP-dependent RNA helicase activity 1.4452E-3 13 28 2 6292
    RNA-dependent ATPase activity 1.5505E-3 13 29 2 6292
    U2 snRNA binding 2.0661E-3 13 1 1 6292
    mRNA binding 2.2564E-3 13 35 2 6292
    RNA helicase activity 3.2387E-3 13 42 2 6292
    ATP-dependent helicase activity 4.2134E-3 13 48 2 6292
    purine NTP-dependent helicase activity 4.2134E-3 13 48 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle