YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes:	This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Dia2. The topolgies of protein complexes in this experiment are unknown.
Complex Size:	33 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
BMS1	nucleus cytoplasm mitochondrion nuclear outer membrane nucleolus	ribosome assembly rRNA processing	GTP binding
CDC53	SCF ubiquitin ligase complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination during ubiquitin-dependent protein catabolic process	DNA replication origin binding ubiquitin-protein ligase activity protein binding, bridging
CIC1	proteasome complex nucleolus	protein catabolic process ribosomal large subunit biogenesis ribosome biogenesis	protein binding, bridging
COF1	actin cortical patch	actin filament severing actin filament depolymerization actin filament organization	protein binding
CTF4	nucleus nuclear chromosome	DNA repair DNA-dependent DNA replication mitotic sister chromatid cohesion replicative cell aging	DNA binding
DBP10	nuclear outer membrane nucleolus	ribosome biogenesis ribosomal large subunit assembly	ATP-dependent RNA helicase activity
DED81	cytoplasm	asparaginyl-tRNA aminoacylation	ATP binding asparagine-tRNA ligase activity
DIA2	SCF ubiquitin ligase complex	DNA replication invasive growth in response to glucose limitation protein ubiquitination	DNA replication origin binding
ENP1	nucleus nuclear outer membrane nucleolus preribosome, small subunit precursor	ribosome biogenesis rRNA processing	snoRNA binding
FPR3	nucleolus	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity
ILS1	cytosol	translation	isoleucine-tRNA ligase activity
KRE33	nucleolus	ribosome biogenesis	molecular_function
KRI1	nucleolus	ribosome biogenesis	molecular_function
LST4	vesicle coat	vesicle-mediated transport protein transport Golgi to plasma membrane transport intracellular protein transport	protein transporter activity
MCM2	nucleus pre-replicative complex cytoplasm MCM complex	DNA replication initiation pre-replicative complex assembly DNA unwinding involved in replication	chromatin binding ATP-dependent DNA helicase activity
MCM3	nucleus pre-replicative complex cytoplasm MCM complex	DNA replication initiation pre-replicative complex assembly DNA unwinding involved in replication	chromatin binding ATP-dependent DNA helicase activity
MCM5	replication fork pre-replicative complex cytoplasm MCM complex	DNA replication initiation establishment of chromatin silencing pre-replicative complex assembly DNA unwinding involved in replication	chromatin binding ATP-dependent DNA helicase activity
NIP7	nucleolus	ribosomal large subunit biogenesis ribosome biogenesis rRNA processing ribosomal large subunit assembly	molecular_function
NMD3	cytosol	ribosomal large subunit export from nucleus ribosome biogenesis ribosomal large subunit assembly	RNA binding protein binding
NOP12	nucleolus	rRNA metabolic process	RNA binding
RRP12	nucleus ribosome	maturation of SSU-rRNA ribosome biogenesis	molecular_function
SEH1	nuclear pore	mRNA export from nucleus rRNA export from nucleus nuclear pore organization snRNP protein import into nucleus mRNA-binding (hnRNP) protein import into nucleus snRNA export from nucleus tRNA export from nucleus NLS-bearing substrate import into nucleus protein export from nucleus ribosomal protein import into nucleus	structural molecule activity
SKP1	RAVE complex nucleus cytoplasm CBF3 complex SCF ubiquitin ligase complex kinetochore	G2/M transition of mitotic cell cycle protein complex assembly regulation of exit from mitosis G1/S transition of mitotic cell cycle cytokinesis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of protein complex assembly protein neddylation kinetochore assembly vacuolar acidification protein ubiquitination during ubiquitin-dependent protein catabolic process	DNA replication origin binding ubiquitin-protein ligase activity protein binding
SLT2	nucleus cellular bud tip cytoplasm	response to acid signal transduction endoplasmic reticulum unfolded protein response regulation of cell size cellular cell wall organization protein amino acid phosphorylation	MAP kinase activity
SPB1	nucleus nucleolus	rRNA methylation processing of 27S pre-rRNA	rRNA (uridine-2'-O-)-methyltransferase activity rRNA (guanine) methyltransferase activity
SSF1	nucleolus	conjugation with cellular fusion regulation of cell size ribosomal large subunit assembly	rRNA binding
SSF2	nucleolus	conjugation with cellular fusion ribosome biogenesis ribosomal large subunit assembly	rRNA binding
SSZ1	cytoplasm	regulation of translational fidelity translation	unfolded protein binding
TIF6	nucleus cytoplasm nuclear outer membrane nucleolus	ribosomal subunit export from nucleus ribosomal large subunit biogenesis processing of 27S pre-rRNA	ribosomal large subunit binding
URB1	nucleolus	rRNA processing processing of 27S pre-rRNA	molecular_function
UTP10	mitochondrion small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis	snoRNA binding
YAK1	nucleus cytoplasm	protein amino acid phosphorylation	protein kinase activity
YBL104C	cytoplasm	biological_process	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nucleolus	6.9127E-13	33	211	14	6292
nuclear lumen	1.115E-11	33	453	17	6292
non-membrane-bounded organelle	3.2395E-10	33	959	21	6292
intracellular non-membrane-bounded organelle	3.2395E-10	33	959	21	6292
organelle lumen	4.2935E-9	33	660	17	6292
intracellular organelle lumen	4.2935E-9	33	660	17	6292
membrane-enclosed lumen	1.0622E-8	33	700	17	6292
nuclear part	2.5227E-7	33	1103	19	6292
MCM complex	4.5364E-6	33	7	3	6292
nucleus	1.2252E-5	33	2041	23	6292
SCF ubiquitin ligase complex	2.1082E-5	33	11	3	6292
cullin-RING ubiquitin ligase complex	4.601E-5	33	14	3	6292
pre-replicative complex	7.028E-5	33	16	3	6292
intracellular part	3.2895E-4	33	4938	33	6292
intracellular organelle part	3.6377E-4	33	2282	22	6292
organelle part	3.6377E-4	33	2282	22	6292
intracellular	4.2117E-4	33	4975	33	6292
nuclear outer membrane	9.8396E-4	33	86	4	6292
ubiquitin ligase complex	1.4064E-3	33	43	3	6292
nuclear membrane	1.5417E-3	33	97	4	6292
protein-DNA complex	3.1721E-3	33	57	3	6292
nuclear envelope	3.471E-3	33	199	5	6292
cell part	6.2364E-3	33	5397	33	6292
cell	6.3134E-3	33	5399	33	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
ribosome biogenesis	2.468E-12	33	346	16	6292
cellular component biogenesis	7.8285E-12	33	694	20	6292
ribonucleoprotein complex biogenesis	8.1671E-12	33	374	16	6292
cellular macromolecular complex subunit organization	3.0155E-9	33	259	12	6292
cellular macromolecular complex assembly	1.6653E-8	33	182	10	6292
ribosomal large subunit biogenesis	3.1201E-8	33	65	7	6292
organelle assembly	4.7653E-8	33	69	7	6292
macromolecular complex subunit organization	1.1123E-7	33	357	12	6292
rRNA metabolic process	3.6121E-7	33	137	8	6292
ribosome assembly	7.7956E-7	33	64	6	6292
macromolecular complex assembly	9.9928E-7	33	281	10	6292
ribosomal large subunit assembly	1.896E-6	33	41	5	6292
rRNA processing	3.3655E-6	33	128	7	6292
ncRNA metabolic process	4.4829E-6	33	257	9	6292
ribonucleoprotein complex assembly	6.6838E-6	33	92	6	6292
ribosomal subunit assembly	8.3545E-6	33	55	5	6292
cellular component assembly	1.6984E-5	33	385	10	6292
pre-replicative complex assembly	3.6281E-5	33	13	3	6292
protein-DNA complex assembly	4.533E-5	33	39	4	6292
DNA unwinding involved in replication	4.601E-5	33	14	3	6292
processing of 27S pre-rRNA	7.028E-5	33	16	3	6292
ncRNA processing	9.8734E-5	33	215	7	6292
cellular process	1.3165E-4	33	4426	32	6292
DNA geometric change	1.4104E-4	33	20	3	6292
DNA duplex unwinding	1.4104E-4	33	20	3	6292
DNA replication	4.0277E-4	33	123	5	6292
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	5.511E-4	33	7	2	6292
DNA replication initiation	6.4435E-4	33	33	3	6292
DNA-dependent DNA replication	8.2248E-4	33	82	4	6292
protein ubiquitination during ubiquitin-dependent protein catabolic process	1.4245E-3	33	11	2	6292
macromolecule metabolic process	1.8962E-3	33	2349	21	6292
RNA processing	3.0129E-3	33	380	7	6292
DNA conformation change	3.3333E-3	33	58	3	6292
obsolete_biological_process	3.6704E-3	33	60	3	6292
cellular macromolecule metabolic process	3.8002E-3	33	2285	20	6292
protein ubiquitination	4.6025E-3	33	65	3	6292
actin filament severing	5.2448E-3	33	1	1	6292
asparaginyl-tRNA aminoacylation	5.2448E-3	33	1	1	6292
establishment of ribosome localization	8.0141E-3	33	26	2	6292
ribosome localization	8.0141E-3	33	26	2	6292
ribosomal subunit export from nucleus	8.0141E-3	33	26	2	6292
nucleic acid metabolic process	8.2459E-3	33	1415	14	6292
G2/M transition of mitotic cell cycle	9.9138E-3	33	29	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
binding	3.2917E-6	33	1294	19	6292
DNA replication origin binding	3.6281E-5	33	13	3	6292
ATP-dependent DNA helicase activity	1.0168E-4	33	18	3	6292
ATP-dependent helicase activity	1.0373E-4	33	48	4	6292
purine NTP-dependent helicase activity	1.0373E-4	33	48	4	6292
chromatin binding	6.4435E-4	33	33	3	6292
DNA helicase activity	7.0419E-4	33	34	3	6292
helicase activity	8.6094E-4	33	83	4	6292
nucleic acid binding	1.5854E-3	33	666	10	6292
sequence-specific DNA binding	2.1785E-3	33	50	3	6292
DNA-dependent ATPase activity	2.8645E-3	33	55	3	6292
rRNA binding	3.0575E-3	33	16	2	6292
protein binding, bridging	4.778E-3	33	20	2	6292
ribosomal large subunit binding	5.2448E-3	33	1	1	6292
ATPase activity, coupled	7.2455E-3	33	149	4	6292
ligase activity	7.4167E-3	33	150	4	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis