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The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. Any constituent part of a cell, the basic structural and functional unit of all organisms. A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. A ubiquitin ligase complex found in the nucleus. A ubiquitin ligase complex found in the cytoplasm.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ubiquitin ligase complex
Acc: GO:0000151
Aspect: Cellular Component
Desc: A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex.
Proteins in PDR annotated with:
   This term: 195 [Search]
   Term or descendants: 607 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000151 - ubiquitin ligase complex (interactive image map)
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