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Protein Overview: XRS2

General Information:
Name(s) found: XRS2 / YDR369C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 854 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Mre11 complex [IPILink to PubMed articleLink to PubMed article]
    Biological Process: double-strand break repair via break-induced replication [TASLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IMPLink to PubMed article]
    sporulation resulting in formation of a cellular spore [IMPLink to PubMed article]
    meiotic DNA double-strand break formation [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    protein binding [IPILink to PubMed article]
    telomeric DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWVVRYQNTL EDGSISFISC CLQAFKTYSI GRSSKNPLII KNDKSISRQH ITFKWEINNS  60
   61 SDLKHSSLCL VNKGKLTSLN KKFMKVGETF TINASDVLKS TIIELGTTPI RIEFEWINEV 120
  121 WNIPPHLTQF RTMLSEYGIS TEISINDIPA NLMISDYPKS EDNSIRELYA LVSTIPMKKS 180
  181 RFLMELCNTL LPTSKTNLKF DEMWNDMISN PEYNVFDFDP NILLSKFMRL NNIRVLTTIK 240
  241 SEPRLSSLLR TFNINLFAFD NIDSLYKYVD SLEASTEYLI LTTTDKKENG KILCTIKTML 300
  301 TSIIDGTLSA VINMKGASSR TLDNGKFDQI SEGMSTILKT SRAPEVEASP VVSKKRKLNR 360
  361 RRVLPLDSLD FFAGGLSTKT LSENRSLTDA KRLNCGAESK TVISSPNIAE ADEKHAPFLQ 420
  421 NALKPTEDIG KKSGHSSPGA IIVSSPNLGT VNTSEDSLDK SLQSHKLPQP SLPEVAGIGS 480
  481 QTISSNSADY ETAAVNSMDD AEVTKNFRVN HHQNIEQPSK NIRKLSNYSR EISSPLQENC 540
  541 KSPVKELSIK EKSGTPHAFV EAIQETKNRE VKRVKSTIVE LKDEELSEEA INQLKNLAIV 600
  601 EPSNNLLRKS FDSEGNKTSR TTEKWENSLM EPEWHKRKNF KTFVKVRPKS KAHKEEGKNN 660
  661 TQSSDFIRNA AFLITRNYVP LKKYSKKDTT TKWGTEENED MFALTEMERF GSNTFMSDNI 720
  721 NSNTIQKRSQ ALNRFTNEDS SNEGEEDSFS FSRCSGTAAS VQPLKNKIFI TDEDDLGDID 780
  781 DKSDRLNHRE NNRNLFVVKE MNLRPNLSEE CSKQSRHSRS ATSRSRGSFG ASNNGDGDDD 840
  841 DDDGPKFTFK RRKG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MRE11 XRS2
    View Details (MIPS) Mewes HW, et al. (2004) MRE11 RAD50 XRS2
    View Details Krogan NJ, et al. (2006) DMC1 MRE11 RAD50 XRS2 YBL044W
    View Details Ho Y, et al. (2002) AHP1 CDC16 DUN1 ERG20 GPH1 MAM33 MKT1 MRE11 PST2 RAD50 REX2 RPT3 SEC27 TFP1 VMA8 XRS2 YBR063C
    View Details Qiu et al. (2008) MRE11 RAD50 XRS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data XRS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157] Pfam 9.468521 FHA domain No confident structure predictions are available.
    2 View Details [158..487] deduced N/A No confident structure predictions are available.
    3 View Details [488..854] MSA 1.002821 View MSA. No confident structure predictions are available.
    4 View Details [498..716] deduced N/A No confident structure predictions are available.
    5 View Details [717..854] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.29282091000252 bayes_pls_golite062009
  • protein binding
    		•  2.10386508653975 bayes_pls_golite062009
  • histone binding
    		•  1.9804501088198 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.80379362156554 bayes_pls_golite062009
  • DNA binding
    		•  1.75711393068958 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.68733623580238 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.64875926701369 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.58213576302578 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.32517364912417 bayes_pls_golite062009
  • chromatin binding
    		•  1.24086020252344 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.23750705623221 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  1.09317005113308 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  0.896922420561378 bayes_pls_golite062009
  • SMAD binding
    		•  0.724800831671259 bayes_pls_golite062009
  • hydrolase activity
    		•  0.721388646103233 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.670370530131427 bayes_pls_golite062009
  • transcription factor activity
    		•  0.539168752590071 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  0.537420543086991 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.520434329676854 bayes_pls_golite062009
  • transcription activator activity
    		•  0.444903517674531 bayes_pls_golite062009
  • ubiquitin binding
    		•  0.306130468133543 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.295271541480997 bayes_pls_golite062009
  • small conjugating protein binding
    		•  0.217876362477623 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.182219412947843 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.00902288416721542 bayes_pls_golite062009
  • promoter binding
    		•  0.00673732596278498 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle