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View Structure Prediction Details

Protein: XRS2
Organism: Saccharomyces cerevisiae
Length: 854 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XRS2.

Description E-value Query
Range
Subject
Range
XRS2 - Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand ...
XRS2_YEAST - DNA repair protein XRS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=XRS2 PE=1 SV=1
0.0 [1..854] [1..854]

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Predicted Domain #1
Region A:
Residues: [1-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWVVRYQNTL EDGSISFISC CLQAFKTYSI GRSSKNPLII KNDKSISRQH ITFKWEINNS  60
   61 SDLKHSSLCL VNKGKLTSLN KKFMKVGETF TINASDVLKS TIIELGTTPI RIEFEWINEV 120
  121 WNIPPHLTQF RTMLSEYGIS TEISINDIPA NLMISDY

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 9.468521
Match: PF00498
Description: FHA domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 3.29282091000252 bayes_pls_golite062009
protein binding 2.10386508653975 bayes_pls_golite062009
histone binding 1.9804501088198 bayes_pls_golite062009
structure-specific DNA binding 1.80379362156554 bayes_pls_golite062009
DNA binding 1.75711393068958 bayes_pls_golite062009
nucleic acid binding 1.68733623580238 bayes_pls_golite062009
double-stranded DNA binding 1.64875926701369 bayes_pls_golite062009
transcription regulator activity 1.58213576302578 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.32517364912417 bayes_pls_golite062009
chromatin binding 1.24086020252344 bayes_pls_golite062009
small conjugating protein ligase activity 1.23750705623221 bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity 1.09317005113308 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity 0.896922420561378 bayes_pls_golite062009
SMAD binding 0.724800831671259 bayes_pls_golite062009
hydrolase activity 0.721388646103233 bayes_pls_golite062009
sequence-specific DNA binding 0.670370530131427 bayes_pls_golite062009
transcription factor activity 0.539168752590071 bayes_pls_golite062009
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity 0.537420543086991 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.520434329676854 bayes_pls_golite062009
transcription activator activity 0.444903517674531 bayes_pls_golite062009
ubiquitin binding 0.306130468133543 bayes_pls_golite062009
acid-amino acid ligase activity 0.295271541480997 bayes_pls_golite062009
small conjugating protein binding 0.217876362477623 bayes_pls_golite062009
damaged DNA binding 0.182219412947843 bayes_pls_golite062009
receptor signaling protein activity 0.00902288416721542 bayes_pls_golite062009
promoter binding 0.00673732596278498 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [158-487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKSEDNSIRE LYALVSTIPM KKSRFLMELC NTLLPTSKTN LKFDEMWNDM ISNPEYNVFD  60
   61 FDPNILLSKF MRLNNIRVLT TIKSEPRLSS LLRTFNINLF AFDNIDSLYK YVDSLEASTE 120
  121 YLILTTTDKK ENGKILCTIK TMLTSIIDGT LSAVINMKGA SSRTLDNGKF DQISEGMSTI 180
  181 LKTSRAPEVE ASPVVSKKRK LNRRRVLPLD SLDFFAGGLS TKTLSENRSL TDAKRLNCGA 240
  241 ESKTVISSPN IAEADEKHAP FLQNALKPTE DIGKKSGHSS PGAIIVSSPN LGTVNTSEDS 300
  301 LDKSLQSHKL PQPSLPEVAG IGSQTISSNS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [488-854]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADYETAAVNS MDDAEVTKNF RVNHHQNIEQ PSKNIRKLSN YSREISSPLQ ENCKSPVKEL  60
   61 SIKEKSGTPH AFVEAIQETK NREVKRVKST IVELKDEELS EEAINQLKNL AIVEPSNNLL 120
  121 RKSFDSEGNK TSRTTEKWEN SLMEPEWHKR KNFKTFVKVR PKSKAHKEEG KNNTQSSDFI 180
  181 RNAAFLITRN YVPLKKYSKK DTTTKWGTEE NEDMFALTEM ERFGSNTFMS DNINSNTIQK 240
  241 RSQALNRFTN EDSSNEGEED SFSFSRCSGT AASVQPLKNK IFITDEDDLG DIDDKSDRLN 300
  301 HRENNRNLFV VKEMNLRPNL SEECSKQSRH SRSATSRSRG SFGASNNGDG DDDDDDGPKF 360
  361 TFKRRKG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [498-716]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDAEVTKNF RVNHHQNIEQ PSKNIRKLSN YSREISSPLQ ENCKSPVKEL SIKEKSGTPH  60
   61 AFVEAIQETK NREVKRVKST IVELKDEELS EEAINQLKNL AIVEPSNNLL RKSFDSEGNK 120
  121 TSRTTEKWEN SLMEPEWHKR KNFKTFVKVR PKSKAHKEEG KNNTQSSDFI RNAAFLITRN 180
  181 YVPLKKYSKK DTTTKWGTEE NEDMFALTEM ERFGSNTFM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [717-854]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDNINSNTIQ KRSQALNRFT NEDSSNEGEE DSFSFSRCSG TAASVQPLKN KIFITDEDDL  60
   61 GDIDDKSDRL NHRENNRNLF VVKEMNLRPN LSEECSKQSR HSRSATSRSR GSFGASNNGD 120
  121 GDDDDDDGPK FTFKRRKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle