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Protein Overview: atp-2

General Information:
Name(s) found: atp-2 / CE29950 [WormBase]
Description(s) found:
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  • WBGene00000229 locus:atp-2 ATP synthase subunit beta, mitochondrial status:Confirmed UniProt:P46561 protein_id:CCD66650.1 [WormBase]
  • gi|25144756|ref|NP_498111.2| ATP synthase subunit family member (atp-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|21431750|sp|P46561.2|ATPB_CAEEL RecName: Full=ATP synthase subunit beta, mitochondrial; Flags: Precursor [NCBI NR]
  • gi|17976515|gb|AAA19068.2| Atp synthase subunit protein 2 [Caenorhabditis elegans] [NCBI NR]
  • ATP synthase subunit beta, mitochondrial OS=Caenorhabditis elegans GN=atp-2 PE=1 SV=2 [Swiss-Prot]
  • [wormpep79.fasta]
  • CE29950 WBGene00000229 locus:atp-2 ATP synthase beta chain status:Confirmed SW:P46561 protein_id:AAA19068.2 [wormpep150.fasta]
  • 29950 WBGene00000229 locus:atp-2 ATP synthase beta chain status:Confirmed SW:P46561 protein_id:AAA19068.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • ATP synthase subunit (57.5 kD) (atp-2) [Caenorhabditis elegans]gi|17976515|gb|AAA19068.2| Atp synthase subunit protein 2 [Caenorhabditis elegans]gi|21431750|sp|P46561|ATPB_CAEEL Probable ATP synthase beta chain, mitochondrial precursor [nrdb_11152004_Chlamydomonas]
  • locus:atp-2 ATP synthase beta chain status:Confirmed SW:P46561 protein_id:AAA19068.2 [wormpep115.fasta.reversed]
  • CE29950 ATP synthase beta chain status:Confirmed SW:P46561 protein_id:AAA19068.2 [wormpep80.hongbin]
  • CE29950 WBGene00000229 locus:atp-2 ATP synthase beta chain status:Confirmed UniProt:P46561 protein_id:AAA19068.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE29950 WBGene00000229 locus:atp-2 ATP synthase beta chain status:Confirmed UniProt:P46561 protein_id:AAA19068.2| [wormORF-contam.fasta]
  • Atp synthase subunit protein 2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • ATP synthase subunit beta, mitochondrial precursor [nr-271106-contam.fasta]
  • ATP synthase subunit family member (atp-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE29950 WBGene00000229 locus:atp-2 ATP synthase beta chain status:Confirmed UniProt:P46561 protein_id:CCD66650.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE29950 WBGene00000229 locus:atp-2 status:Confirmed UniProt:P46561 protein_id:CCD66650.1 ATP synthase subunit beta, mitochondrial [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 538 amino acids

    Gene Ontology:
    Cellular Component: proton-transporting two-sector ATPase complex [IEALink to PubMed article]
    bacterial-type flagellum [IEALink to PubMed article]
    cytoplasm [IEALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    cilium [IDALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    protein transport [IEALink to PubMed article]
    flagellum assembly [IEALink to PubMed article]
    transcription termination [IEALink to PubMed article]
    biosynthetic process [IEALink to PubMed article]
    ATP biosynthetic process [IEALink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    mating behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    ciliary or flagellar motility [IEALink to PubMed article]
    protein secretion by the type III secretion system [IEALink to PubMed article]
    energy coupled proton transport, against electrochemical gradient [IEALink to PubMed article]
    ATP synthesis coupled proton transport [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    ATPase activity [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein domain specific binding [IPILink to PubMed article]
    transcription termination factor activity [IEALink to PubMed article]
    nucleoside-triphosphatase activity [IEALink to PubMed article]
    proton-transporting ATPase activity, rotational mechanism [IEALink to PubMed article]
    hydrogen-exporting ATPase activity, phosphorylative mechanism [IEALink to PubMed article]
    hydrogen ion transporting ATP synthase activity, rotational mechanism [IEALink to PubMed article]
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASRSLASIS RSASRLLQSN VQKCALPAAS IRLSSNNVES KKGIHTGVAT QQAAAATKVS  60
   61 AKATAANASG RIVAVIGAVV DVQFDENLPP ILNGLEVVGR SPRLILEVSQ HLGDNVVRCI 120
  121 AMDGTEGLVR GQPVADTGDP IKIPVGPETL GRIMNVIGEP IDERGPIASK NFAAIHAEAP 180
  181 EFVEMSVEQE ILVTGIKVVD LLAPYAKGGK IGLFGGAGVG KTVLIMELIN NVAKAHGGYS 240
  241 VFAGVGERTR EGNDLYHEMI EGGVIDLKGK NSKVSLVYGQ MNEPPGARAR VCLTGLTVAE 300
  301 YFRDQEGQDV LLFIDNIFRF TQAGSEVSAL LGRIPSAVGY QPTLATDMGS MQERITTTKK 360
  361 GSITSVQAIY VPADDLTDPA PATTFAHLDA TTVLSRGIAE LAIYPAVDPL DSTSRIMDPN 420
  421 VVGQNHYDIA RGVQKILQDY KSLQDIIAIL GMDELSEEDK LTVSRARKIQ RFLSQPFQVA 480
  481 EVFTGHQGKF VSLEETIRGF TMILKGELDH LPEVAFYMQG GIDDVFKKAE ELAKQHGN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..538] PSI-BLAST 1000.0 F1 ATP synthase beta subunit, domain 3; F1 ATP synthase beta subunit, domain 1; Central domain of beta subunit of F1 ATP synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  10.4627263027269 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  9.07129841752891 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  7.35625288284796 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  6.62734320850541 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  4.03326929098701 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4837867129694 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  3.28373827150339 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  2.31476707827367 bayes_pls_golite062009
  • binding
    		•  2.21604035604783 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • hydrolase activity
    		•  1.65763522573119 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.56007674693172 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.53142082854758 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.52938239070386 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.52887308780164 bayes_pls_golite062009
  • nucleotide binding
    		•  1.52746968836881 bayes_pls_golite062009
  • ATP binding
    		•  1.23942044024113 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.21044170258803 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.19481945569892 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.03415266410463 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.908137002406423 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.905276329867465 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • potassium channel activity
    		•  0.843657228494419 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  0.69784475011795 bayes_pls_golite062009
  • kinase activity
    		•  0.641541011250583 bayes_pls_golite062009
  • cation channel activity
    		•  0.601686039699302 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  0.563503770238611 bayes_pls_golite062009
  • protein kinase activity
    		•  0.529485140575818 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.503971340374059 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.46842047319323 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.40876498215632 bayes_pls_golite062009
    		• 0.3586311431823 bayes_pls_golite062009
  • helicase activity
    		•  0.32448546535964 bayes_pls_golite062009
  • gated channel activity
    		•  0.299411774392227 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.226231702119567 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.175442402308287 bayes_pls_golite062009
  • ion channel activity
    		•  0.154779598791225 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.134817721656507 bayes_pls_golite062009
  • channel activity
    		•  0.134817721656507 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.126911677161968 bayes_pls_golite062009
  • DNA binding
    		•  0.111331583742205 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.57

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle