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Protein Overview: ppk35

General Information:
Name(s) found: ppk35 / SPCC417.06c [Sanger Pombe]
Description(s) found:
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  • pir||T41341 probable serine-threonine-protein kinase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74676203|sp|O94487.1|PPK35_SCHPO RecName: Full=Serine/threonine-protein kinase ppk35; AltName: Full=Meiotically up-regulated gene 27 protein [NCBI NR]
  • gi|4107283|emb|CAA22652.1| meiosis specific protein kinase Mug27/Slk1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075783|ref|NP_588283.1| serine/threonine protein kinase Ppk35 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • serine/threonine protein kinase Ppk35 [Sanger Pombe]
  • Serine/threonine-protein kinase ppk35 OS=Schizosaccharomyces pombe GN=ppk35 PE=1 SV=1 [Swiss-Prot]
  • PUTATIVE SERINE/THREONINE PROTEIN KINASE: O94487; [pompepVF.fasta]
  • PUTATIVE SERINE-THREONINE-PROTEIN KINASE: O94487; [pompepV13]
  • Probable serine-threonine-protein kinase [pompep4896]
  • |||putative serine/threonine protein kinase [pompepnew.fasta]
  • SPCC417.06c protein [4896.FASTAC]
  • |||serine/threonine protein kinase (predicted)|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • probable serine-threonine-protein kinase [Schizosaccharomyces pombe]gi|4107283|emb|CAA22652.1| SPCC417.06c [Schizosaccharomyces pombe]gi|7492958|pir||T41341 probable serine-threonine-protein kinase - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |||serine/threonine protein kinase |Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • (O94487) Probable serine-threonine-protein kinase [pompep4896_normal_reversed]
  • |mug27|ppk35, slk1|meiosis specific protein kinase Mug27/Slk1|Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPCC417.06c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPCC417.06c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Serine/threonine-protein kinase ppk35 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ppk35 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 624 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    prospore membrane [IDALink to PubMed articleLink to PubMed article]
    spindle pole body [IDALink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: regulation of vacuole fusion, non-autophagic [IMPLink to PubMed article]
    ascospore-type prospore membrane assembly [IMPLink to PubMed articleLink to PubMed article]
    signal transduction [IGILink to PubMed article]
    meiotic chromosome segregation [IMPLink to PubMed article]
    ascospore-type prospore formation [IGILink to PubMed article]
    protein amino acid phosphorylation [ISSLink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein serine/threonine kinase activity [ISSLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLLGLKELD NNKLVSKAKE NGVEFSDLFL LSSGYLRDRE NASASVSSKN ERMVLNEERQ  60
   61 NCWTKRNDPK GLTYYQLLKP SEVEILSRPE TRRKRMACQV FFLNYYISTI EYHKLRKERL 120
  121 EEFTACTSSL KQSKQKRLWK EHCGRERAFL RKKRTKIQCS HFDLLVKLGQ GGYGSVWLAK 180
  181 KRNTHELLAM KMMKKSTLQQ LNEVKHILNE RDILTNTNSE WLVKLYYAFQ DKEKVYLAME 240
  241 YVPGGDFRTF LTTKGLLHEN QTRFYLAEMV AAISAVHKLG YMHRDLKPEN FLIDQKGHIK 300
  301 LSDFGLSTAI VTSNQVNRLQ HALVSAVNPQ RPYLTQKQRR NIYKALLEKN ENKVNSVVGS 360
  361 PEYMAPEVVY GKKYDRTVDY WSLGCICYEC LVGYPPFSGS TLQETWTNLY YWREMLQRPS 420
  421 KNENGIYDKK ARSVSDEAWS FITKCLTEPT SRFQSTIEIQ KHPFFKRLHW NGLRKRAVPP 480
  481 FVPRLENQLD TSYFDDFNDE QVLDAYKDVY EKQRKAEQKA KSNGVMNGNQ RQFLGFTFKY 540
  541 RPNARKPLVG RHREKRQLRK EKPEKKNNST KQKDLITVSH NKGTTAIEDL DEDKRSKTKG 600
  601 HKTKSSRVHR LLERKGKDLY EFLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..479] PSI-BLAST 71.69897 CHICKEN SRC TYROSINE KINASE
    2 View Details [480..543] FFAS03 1.5 No description for 2f2uA was found.
    3 View Details [544..624] PSI-BLAST 3.522879 Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol (1,3,4,5)-tetrakisphosphate

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • actin binding
    		•  2.91722352767433 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.11596088488502 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • growth factor binding
    		•  1.93447870907639 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • actin filament binding
    		•  1.75933904320288 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.61430967760189 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  1.55257528159541 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  1.5013287968167 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  1.43713739644553 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.33492884190781 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.28428643482914 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.10656898538153 bayes_pls_golite062009
  • structural molecule activity
    		•  1.10436308210353 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • telethonin binding
    		•  0.953133636042811 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.925299895386908 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.835012681606991 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.835012681606991 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.832111648073981 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  0.688047400629641 bayes_pls_golite062009
  • vinculin binding
    		•  0.666656406096231 bayes_pls_golite062009
  • ligase activity
    		•  0.665445021164512 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.312169974523858 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • myosin binding
    		•  0.259936573810332 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.0923798087054641 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.0339299940546054 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  0.01826424351081 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle