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View Structure Prediction Details

Protein: ppk35
Organism: Schizosaccharomyces pombe
Length: 624 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ppk35.

Description E-value Query
Range		 Subject
Range
gi|22135803, gi|... - gi|30682811|ref|NP_849380.1| protein kinase family protein [Arabidopsis thaliana], gi|30682806|ref|N...
 357.0 [0..69] [588..24]
gi|31088228 - gi|31088228|dbj|BAC76896.1| protein kinase [Raphanus sativus]
 341.0 [0..79] [594..9]
gi|7339534 - gi|7339534|emb|CAB82852.1| protein kinase MK6 [Mesembryanthemum crystallinum]
 339.0 [0..63] [588..24]

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Predicted Domain #1
Region A:
Residues: [1-479] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLLGLKELD NNKLVSKAKE NGVEFSDLFL LSSGYLRDRE NASASVSSKN ERMVLNEERQ  60
   61 NCWTKRNDPK GLTYYQLLKP SEVEILSRPE TRRKRMACQV FFLNYYISTI EYHKLRKERL 120
  121 EEFTACTSSL KQSKQKRLWK EHCGRERAFL RKKRTKIQCS HFDLLVKLGQ GGYGSVWLAK 180
  181 KRNTHELLAM KMMKKSTLQQ LNEVKHILNE RDILTNTNSE WLVKLYYAFQ DKEKVYLAME 240
  241 YVPGGDFRTF LTTKGLLHEN QTRFYLAEMV AAISAVHKLG YMHRDLKPEN FLIDQKGHIK 300
  301 LSDFGLSTAI VTSNQVNRLQ HALVSAVNPQ RPYLTQKQRR NIYKALLEKN ENKVNSVVGS 360
  361 PEYMAPEVVY GKKYDRTVDY WSLGCICYEC LVGYPPFSGS TLQETWTNLY YWREMLQRPS 420
  421 KNENGIYDKK ARSVSDEAWS FITKCLTEPT SRFQSTIEIQ KHPFFKRLHW NGLRKRAVP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.69897
Match: 2ptkA
Description: CHICKEN SRC TYROSINE KINASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
actin binding 2.91722352767433 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
structural constituent of muscle 2.11596088488502 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
growth factor binding 1.93447870907639 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.9016235206634 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
actin filament binding 1.75933904320288 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.61430967760189 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 1.55257528159541 bayes_pls_golite062009
phosphoinositide 3-kinase activity 1.5013287968167 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
1-phosphatidylinositol-3-kinase activity 1.43713739644553 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
ErbB-3 class receptor binding 1.33492884190781 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.28428643482914 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
ErbB-2 class receptor binding 1.10656898538153 bayes_pls_golite062009
structural molecule activity 1.10436308210353 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
cation channel activity 1.04999722123563 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
telethonin binding 0.953133636042811 bayes_pls_golite062009
sequence-specific DNA binding 0.925299895386908 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.835012681606991 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.835012681606991 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.832111648073981 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 0.688047400629641 bayes_pls_golite062009
vinculin binding 0.666656406096231 bayes_pls_golite062009
ligase activity 0.665445021164512 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
peptide hormone binding 0.312169974523858 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
channel activity 0.287189255116606 bayes_pls_golite062009
passive transmembrane transporter activity 0.287189255116606 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
substrate-specific channel activity 0.261869836686301 bayes_pls_golite062009
myosin binding 0.259936573810332 bayes_pls_golite062009
ion channel activity 0.241519346930618 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
cytokine binding 0.17817111033393 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
alpha-actinin binding 0.0923798087054641 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
actin-dependent ATPase activity 0.0339299940546054 bayes_pls_golite062009
MAP kinase kinase kinase kinase activity 0.01826424351081 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [480-543] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFVPRLENQL DTSYFDDFND EQVLDAYKDV YEKQRKAEQK AKSNGVMNGN QRQFLGFTFK  60
   61 YRPN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.5
Match: 2f2uA
Description: No description for 2f2uA was found.

Predicted Domain #3
Region A:
Residues: [544-624] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARKPLVGRHR EKRQLRKEKP EKKNNSTKQK DLITVSHNKG TTAIEDLDED KRSKTKGHKT  60
   61 KSSRVHRLLE RKGKDLYEFL L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1w1dA
Description: Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol (1,3,4,5)-tetrakisphosphate
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle