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Protein Overview: shark-PA

General Information:
Name(s) found: shark-PA / FBpp0086382 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Src homology 2, ankyrin repeat, tyrosine kinase is referred to in FlyBase by the symbol Dmel\shark (CG18247, FBgn0015295). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12086928..12090388. It has the cytological map location 52F8. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: dorsal closure, elongation of leading edge cells; eggshell chorion assembly; JNK cascade; apoptotic cell clearance; maintenance of epithelial cell apical/basal polarity; dorsal appendage formation. 13 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 939 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    cell cortex [IDA]
    Biological Process: dorsal closure [TAS]
    eggshell chorion assembly [IMP][NAS]
    maintenance of epithelial cell apical/basal polarity [IEP]
    dorsal closure, elongation of leading edge cells [IMP]
    apoptotic cell clearance [IMP]
    dorsal appendage formation [IGI][IMP][NAS]
    JNK cascade [IGI][IMP][NAS]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IEA][ISS][NAS]
    protein binding [IEA]
    non-membrane spanning protein tyrosine kinase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRDSDPMKW YHGNLSREAA DELLKQGYED GTFLVRESST AAGDFVLSLL CQGEVCHYQV  60
   61 RRHGGEDAFF SIDDKVQTKI LHGLDTLVDY YQQAANGLPT KLTVPLIRDL PPHNTRSHGV 120
  121 TNLLHRATSK NESKVVFELL KCGYRNFDAK NQDGQTALHL AALHSDEDIL KHLLNAKVQV 180
  181 NSSDSFGCQP LHYAARSKPA SFIRTLISAQ ANVQGRNIDN GYVPLHEAAK HGNLEAVQEL 240
  241 LLAEAPPLPR TSSGEFPFDL AKEAGQTAVE EFLLNYKLPP ANTTRDQWYH GTLTREEAVA 300
  301 ILKKHAKELL AKQPEVDTSG CFLVRYSESP AASGLVLTLL CDQVVKNFRI SQADLYQNGN 360
  361 KVQSGGSKFL YIDDGPYWPS VEHLIAHFMR FSYGLPVSLK YPVPPQPKPE VPSFATIPRS 420
  421 NMKPKAASPA TPPTPVSPHS HHQHPHVPAL TITKKKQKEN SSSMFNTLRL TSPKKALFDM 480
  481 NSLRKNKSKG KRSDSESSVS GSLAGTEQEL QAAAPMLKSL SFSTEFSTFN ADGVTGSGAA 540
  541 AAGEVYNVPR NNTPIEIDLP PIAQKTEAEV EYFTKSDVAI ERERAGQWIG NGYQPTMDVL 600
  601 SLLDQQIKAP AVARLNSLGP NASTESEMAS YLHRKCSGTP STPSATEVEA AKLRFFIEPE 660
  661 KLVLDREIGH GEFGSVHSGW LLRKSGAGEE SRLEVAIKML SDEHSNKQEF LREASVMMRL 720
  721 EHKCIVRLIG IAKGEMLMMV QELAPLGSML QYILDHGHEI TANAELKVWA SQIACGMHYL 780
  781 ESQHFVHRDL AARNILLTAR HQAKISDFGM SRSLRPGSTE YQFTQGGRWP IRWYAPESFN 840
  841 LGIFSHASDV WSFGVTIWEM FSLGAPPYGE ISNVDAIKLV DSGERLPQPN LCPAYIYAVM 900
  901 QSCWKERPKD RPTFVYLTEF FARDPDYQNL PELVQTVHI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..355] PSI-BLAST 49.221849 Ankyrin-R
    2 View Details [356..463] FFAS03 3.17 Hemapoetic cell kinase Hck; Hemopoetic cell kinase Hck; Haemopoetic cell kinase Hck
    3 View Details [464..939] PSI-BLAST 96.69897 No description for 2h8hA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.56691760558785 bayes_pls_golite062009
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • actin binding
    		•  2.66339417940702 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • actin filament binding
    		•  1.79702615462276 bayes_pls_golite062009
  • protein kinase activity
    		•  1.44085162459605 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.24901082343235 bayes_pls_golite062009
  • signal transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • receptor activity
    		•  1.22857731988464 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.22209007484238 bayes_pls_golite062009
  • kinase activity
    		•  1.20122575201235 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.10325771560525 bayes_pls_golite062009
  • transcription factor binding
    		•  0.84590123339816 bayes_pls_golite062009
  • transporter activity
    		•  0.782432203646924 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.653190853243002 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.589753112911856 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.515634991066501 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.375391185084903 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.3210142108162 bayes_pls_golite062009
  • transcription activator activity
    		•  0.295016294965448 bayes_pls_golite062009
  • transferase activity
    		•  0.291085370218412 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.280340492381105 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.238966076323951 bayes_pls_golite062009
  • DNA binding
    		•  0.139886855398905 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.108244697820437 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0675641359654993 bayes_pls_golite062009
  • channel activity
    		•  0.0675641359654993 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  3.31264000585107 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • actin binding
    		•  2.42703012169921 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.38494443043195 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • actin filament binding
    		•  1.68048469859634 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • integrin binding
    		•  1.44154155381408 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.95914323793919 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.91037901281763 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  0.01826424351081 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle