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Protein Overview: VPS16

General Information:
Name(s) found: VPS16 / YPL045W [SGD]
Description(s) found:
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  • gi|6325212|ref|NP_015280.1| Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein tra [NCBI NR]
  • gi|2507153|sp|Q03308.2|VPS16_YEAST RecName: Full=Vacuolar protein sorting-associated protein 16; AltName: Full=Vacuolar morphogenesis protein 9; AltName: Full=Vacuolar protein-targeting protein 16 [NCBI NR]
  • pir||S62031 vacuolar protein sorting-associated protein VPS16 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1171414|gb|AAB68176.1| Vsp16p: Vacuolar sorting protein [Saccharomyces cerevisiae] [NCBI NR]
  • Vacuolar protein sorting-associated protein 16 OS=Saccharomyces cerevisiae GN=VPS16 PE=1 SV=2 [Swiss-Prot]
  • (Q03308) Vacuolar protein sorting-associated protein VPS16 [Swiss-Prot]
  • VPS16 Vacuolar sorting protein [mips]
  • Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages [SGD]
  • Chr XVI from 467255-469651 [hmr_yeast5_DM3-1_pombe.fasta]
  • VPS16, Chr XVI from 467255-469651 [yeast_orfs2]
  • VPS16 SGDID:S0005966, Chr XVI from 467255-469651, Verified ORF [yeastflysequest.fasta]
  • VPS16 SGDID:S0005966, Chr XVI from 467257-469653, Verified ORF [10112005cervSGD.fasta]
  • Vacuolar sorting protein [Saccharomyces cerevisiae]gi|2507153|sp|Q03308|VP16_YEAST Vacuolar protein sorting-associated protein VPS16gi|1171414|gb|AAB68176.1| Vsp16p: Vacuolar sorting protein [Saccharomyces cerevisiae]gi|2133204|pir||S62031 vacuolar pro [nrdb_11152004_Chlamydomonas]
  • VPS16 SGDID:S000005966, Chr XVI from 467257-469653, Verified ORF, "Subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; part of the Class C Vps complex essential for membrane docking and fusion at both the Golgi-to-endosome [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • VPS16 SGDID:S000005966, Chr XVI from 467257-469653, Verified ORF, "Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endos [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Vsp16p: Vacuolar sorting protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Vacuolar protein sorting-associated protein 16 (Vacuolar morphogenesis protein 9) (Vacuolar protein-targeting protein 16) [nr-271106-contam.fasta]
  • Subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; part of the Class C Vps complex essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport; Vps16p [Saccha [nr-271106-contam.fasta]
  • VPS16 SGDID:S000005966, Chr XVI from 467257-469653, Verified ORF, "Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages" [yeast-bovrabprots.fasta]
  • VPS16 SGDID:S000005966, Chr XVI from 467257-469653, Verified ORF, "Subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; part of the Class C Vps complex essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Vacuolar protein sorting-associated protein 16 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS16 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • VPS16 SGDID:S000005966, Chr XVI from 467260-469656, Genome Release 64-1-1, Verified ORF, "Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages" [yeast-030211-contam.fasta]
  • VPS16 SGDID:S000005966, Chr XVI from 467260-469656, Genome Release 64-2-1, Verified ORF, "Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages" [20141208_orf_trans.fasta]
  • YPL045W SGDID:S000005966, Chr XVI from 467260-469656, Genome Release 64-1-1, Verified ORF, "Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 798 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    vacuolar membrane [IDALink to PubMed article]
    HOPS complex [IPILink to PubMed article]
    Biological Process: vacuole organization [IMPLink to PubMed article]
    late endosome to vacuole transport [IGILink to PubMed article]
    vacuole fusion, non-autophagic [IDALink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Golgi to endosome transport [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNPSFDWER LKDVFYRSRA IGELKWPTQY EEFKCALSLT VIAVEIQDFI QVYNYFGQLL  60
   61 GKINLQRIHE DIIKFEFDKD EKLILVTKSS IKIVKGWSPL TIESVPLQDP TIDTIWDYHN 120
  121 GIMLLAKSRD IYKLNGNEWE LLYENKDKKY NLLTKNHWSC NDDSIILLDV DHVYQVSTSN 180
  181 GALLKLITDS SWHKVTISSR GFICLYNMKD NKLQIFRDPA RILMEHNLDS TPDDICWCGN 240
  241 DTVACSFEDE IKLYGPDGLY VTFWYPFTVT NLRAEVDGLK VITTEKIYFL SRVQPQTSNI 300
  301 FRIGSTEPGA MLVDSFSLLE DHAPKAIEIL KNFVLEKGVL DCIAAAIDEF EPKLQKMLLN 360
  361 AASYGKASLQ YKSFDASIFV NACNTIKLLN CFRSFGIFLT VEEYRCISLK GVIDRLLKYH 420
  421 RYYECIQICK LANERFLLGY VFTEWAKDKI KGSPDMEDDE LLDKIKSRLS VIDMTDTLQM 480
  481 VAVAKVAYLE GRFQLSRNLA LLEKNEEARI EQLYNLDDDS IALKECIKVQ NYSLTISLLI 540
  541 ALSKKLTNSQ LTKLLIIDMF NNPLYLYYMR MDKAYLYDFY RQTDRFIDLA HVLLQQGKEQ 600
  601 QSLHSFLPQI KDLYSQVQNS EVVNNTIEQL QRQEKLWIYQ ESLGKRFAIS FTNMTLDQTL 660
  661 SKLIETGQDK QVKEIVKKFK ISEKKLYHLK CKTLVEAKKF DELLQFAQSR KSPIGYMPFY 720
  721 TYLKSRGHMD KASPYVNMIP GLSYQEKKKL YVECRGFRDA IQLAGKEKDI PGLKEIYNII 780
  781 PPNEPELKAL ANETMSRI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PEP3 PEP5 VAM6 VPS16 VPS33 VPS41 VPS8
    View Details (MIPS) Mewes HW, et al. (2004) PEP3 PEP5 VPS16 VPS33
    View Details Gavin AC, et al. (2006) PEP3 PEP5 VAM6 VPS16 VPS33 VPS41 VPS8
    View Details Gavin AC, et al. (2002) ATP8 LUC7 PEP3 PEP5 SNU71 VAM6 VPS16 VPS33 VPS41 VPS8
    View Details Qiu et al. (2008) PEP3 PEP5 VPS16 VPS33

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 VPS16 2 Unpublished Fields Lab Data
    View Screen MET18 VPS16 1 Unpublished Fields Lab Data
    View Screen NUP2 VPS16 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS16 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..432] MSA 1.015926 View MSA. No confident structure predictions are available.
    2 View Details [433..619] deduced N/A No confident structure predictions are available.
    3 View Details [620..798] MSA 1.017963 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle