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Protein Overview: VAM6

General Information:
Name(s) found: VAM6 / YDL077C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1049 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    vacuolar membrane [IDALink to PubMed article]
    HOPS complex [IPILink to PubMed article]
    Biological Process: vacuole organization [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    vacuole fusion, non-autophagic [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: Rab guanyl-nucleotide exchange factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRAQKLHSL KSSDITAILP TEQSQKLVLA KKNGDVEVYS RDGNTLKLFQ VYPDLLQNAK  60
   61 NDPLPPVIEN FYFANELSTI FAQCKETLIL LSTTNLHEYD RIIDRRGINH CWLFERSHKN 120
  121 KEEKNTYLIY STINTAKMRV LIWEGRTYKN MMEASLSYRK ETIRSIYPGE TGITLATDLG 180
  181 IYHWPYNKPS LIRIEKTVKN KFPKDMISAL TELKEQAEKV IEKKPKKNSH FDAQSFSSMD 240
  241 RMSRKSSMSS LWYRTIRNER GNKIRYTFEL DGNDATPMII DGATKKIFKV ELMHNNEEPF 300
  301 LIATDHATFS ESNSEFDHMQ YLSSNLLMLY NSSTIKFVDY ENGFTFLQQK IPEGIKWVKN 360
  361 LSGTYFLVWT SNDEVQLFSY HVDDGSEDDD QESICGDIND PDFYQLWRKV LFYKFFIDSP 420
  421 HSKELCVSDN PEESLDICAM KLRDLTVMWC LRIFDKFQNY MVQLERSRNS RMIRSKCEEM 480
  481 IIKSIFDLFI KFWAPPQLVI LKVFPSAISS LVLEITGQEH HCLLKEAEEV KETYDIPPHL 540
  541 LNRWCLPYLT DTRRHLQNLL SKENDDESRI TWCYRDREIK QSFDFFLISN HDDVDLNTML 600
  601 TLIDTVLFKC YLYYNPPMVG PFIRVENHCD SHVIVTELKI RHMFKDLIDF YYKRGNHEEA 660
  661 LKFLTDLVDE LENDNTDQKQ RQKIDHGVKI LVIYYLKKLS NPQLDVIFTY TDWLLNRHND 720
  721 SIKEILSSIF FYDSQACSSR DHLKVYGYIK KFDKLLAIQY LEFAISTFRL EGNKLHTVLI 780
  781 KLYLENLDIP STRIKLKSLL ETTSVYEPRT ILKLLNDAIE SGSDQLPTNQ LNFVKYLKIF 840
  841 PLSKLENHKE AVHILLDEID DYKAATSYCN DVYQSDSTKG EELLLYLYSK LVSIYDSNRN 900
  901 SKLILNFLQD HGSKLNSAEI YKNLPQDISL YDIGRVVSQL LKKHTSKMDE TRLEKALLQV 960
  961 ELVATTYKLN ERMSSYGVLS DSHKCPICKK VISNFGTDSI SWFTREGRNI ITHYNCGKVL1020
 1021 QERFNAKNEK SSRIKQKTLG EVINELNNK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PEP3 PEP5 VAM6 VPS16 VPS33
    View Details (MIPS) Mewes HW, et al. (2004) VAM6 VPS41
    View Details Krogan NJ, et al. (2006) RLM1 TPA1 VAM6 YOR051C
    View Details Gavin AC, et al. (2006) PEP3 PEP5 VAM6 VPS16 VPS33 VPS41 VPS8
    View Details Gavin AC, et al. (2002) ATP8 LUC7 PEP3 PEP5 SNU71 VAM6 VPS16 VPS33 VPS41 VPS8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run VAM3 sample: hx1 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VAM6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..420] deduced N/A No confident structure predictions are available.
    2 View Details [421..544] MSA 1.028988 View MSA. Confident ab initio structure predictions are available.
    3 View Details [545..859] PSI-BLAST 41.045757 Clathrin heavy chain proximal leg segment
    4 View Details [860..974] MSA 1.08399 View MSA. Confident ab initio structure predictions are available.
    5 View Details [975..1049] MSA 19.090997 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle