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View Structure Prediction Details

Protein: VAM6
Organism: Saccharomyces cerevisiae
Length: 1049 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VAM6.

Description E-value Query
Range
Subject
Range
VAM6 - Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by fa...
VAM6_YEAST - Vacuolar morphogenesis protein 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VAM6 PE...
0.0 [1..1049] [1..1049]
gi|25453320, gi|... - sp|Q96JC1|VP39_HUMAN Vam6/Vps39-like protein (hVam6p), gi|14701768|gb|AAK72222.1| Vam6/Vps39-like p...
5.0E-84 [483..1019] [321..880]
VPS39_MOUSE - Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=1 SV=1
7.0E-84 [483..1019] [321..880]
gi|18071340, gi|... - gi|50918315|ref|XP_469554.1| TGF beta receptor associated protein-like protein [Oryza sativa (japoni...
3.0E-76 [423..903] [339..823]
gi|15221363 - gi|15221363|ref|NP_172709.1| Pep3/Vps18/deep orange family protein [Arabidopsis thaliana]
1.0E-73 [358..1048] [307..917]

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Predicted Domain #1
Region A:
Residues: [1-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRAQKLHSL KSSDITAILP TEQSQKLVLA KKNGDVEVYS RDGNTLKLFQ VYPDLLQNAK  60
   61 NDPLPPVIEN FYFANELSTI FAQCKETLIL LSTTNLHEYD RIIDRRGINH CWLFERSHKN 120
  121 KEEKNTYLIY STINTAKMRV LIWEGRTYKN MMEASLSYRK ETIRSIYPGE TGITLATDLG 180
  181 IYHWPYNKPS LIRIEKTVKN KFPKDMISAL TELKEQAEKV IEKKPKKNSH FDAQSFSSMD 240
  241 RMSRKSSMSS LWYRTIRNER GNKIRYTFEL DGNDATPMII DGATKKIFKV ELMHNNEEPF 300
  301 LIATDHATFS ESNSEFDHMQ YLSSNLLMLY NSSTIKFVDY ENGFTFLQQK IPEGIKWVKN 360
  361 LSGTYFLVWT SNDEVQLFSY HVDDGSEDDD QESICGDIND PDFYQLWRKV LFYKFFIDSP 420
  421 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [421-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSKELCVSDN PEESLDICAM KLRDLTVMWC LRIFDKFQNY MVQLERSRNS RMIRSKCEEM  60
   61 IIKSIFDLFI KFWAPPQLVI LKVFPSAISS LVLEITGQEH HCLLKEAEEV KETYDIPPHL 120
  121 LNRW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.805 0.005 vacuolar membrane a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3

Predicted Domain #3
Region A:
Residues: [545-859]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CLPYLTDTRR HLQNLLSKEN DDESRITWCY RDREIKQSFD FFLISNHDDV DLNTMLTLID  60
   61 TVLFKCYLYY NPPMVGPFIR VENHCDSHVI VTELKIRHMF KDLIDFYYKR GNHEEALKFL 120
  121 TDLVDELEND NTDQKQRQKI DHGVKILVIY YLKKLSNPQL DVIFTYTDWL LNRHNDSIKE 180
  181 ILSSIFFYDS QACSSRDHLK VYGYIKKFDK LLAIQYLEFA ISTFRLEGNK LHTVLIKLYL 240
  241 ENLDIPSTRI KLKSLLETTS VYEPRTILKL LNDAIESGSD QLPTNQLNFV KYLKIFPLSK 300
  301 LENHKEAVHI LLDEI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.045757
Match: 1b89A_
Description: Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [860-974]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDYKAATSYC NDVYQSDSTK GEELLLYLYS KLVSIYDSNR NSKLILNFLQ DHGSKLNSAE  60
   61 IYKNLPQDIS LYDIGRVVSQ LLKKHTSKMD ETRLEKALLQ VELVATTYKL NERMS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.853 0.020 vacuolar membrane a.24.4 Hemerythrin

Predicted Domain #5
Region A:
Residues: [975-1049]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYGVLSDSHK CPICKKVISN FGTDSISWFT REGRNIITHY NCGKVLQERF NAKNEKSSRI  60
   61 KQKTLGEVIN ELNNK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle