Protein Overview: SLK19

General Information:
Name(s) found:	SLK19 / YOR195W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74583736\|sp\|Q08581.1\|SLK19_YEAST RecName: Full=Kinetochore protein SLK19; AltName: Full=Synthetic lethal KAR3 protein 19 [NCBI NR] gi\|6324769\|ref\|NP_014838.1\| Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p [NCBI NR] pir\|\|S67087 hypothetical protein YOR195w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1420465\|emb\|CAA99408.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Kinetochore protein SLK19 OS=Saccharomyces cerevisiae GN=SLK19 PE=1 SV=1 [Swiss-Prot] SLK19 Protein involved in control of spindle dynamics together with kar3p [mips] Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate [SGD] >Q08581 (Q08581) Chromosome XV reading frame ORF YOR195W [4932.FASTACCERV.txt] Chr XV from 712866-715331 [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 712865-715330 [yeastorf3.fasta] SLK19, Chr XV from 712865-715330 [yeast_orfs2] SLK19 SGDID:S0005721, Chr XV from 712866-715331, Verified ORF [yeastflysequest.fasta] Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate [Saccharomyces cer [nrdb_11152004_Chlamydomonas] (Q08581) S.cerevisiae chromosome XV reading frame ORF YOR195w [cerv4932.FASTAC] SLK19 SGDID:S000005721, Chr XV from 712866-715331, Verified ORF, "Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleo [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SLK19 SGDID:S000005721, Chr XV from 712867-715332, Verified ORF, "Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleo [yeast-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate; Slk19p [Saccharom [nr-271106-contam.fasta] SLK19 SGDID:S000005721, Chr XV from 712867-715332, Verified ORF, "Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate" [yeast-bovrabprots.fasta] [chemostatdb.fasta] SLK19 SGDID:S0005721, Chr XV from 712866-715331 [DAS20-2-Contrast.fasta] Kinetochore protein SLK19 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLK19 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SLK19 SGDID:S000005721, Chr XV from 712866-715331, Genome Release 64-1-1, Verified ORF, "Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate" [yeast-030211-contam.fasta] SLK19 SGDID:S000005721, Chr XV from 712866-715331, Genome Release 64-2-1, Verified ORF, "Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate" [20141208_orf_trans.fasta] YOR195W SGDID:S000005721, Chr XV from 712866-715331, Genome Release 64-1-1, Verified ORF, "Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	821 amino acids
Gene Ontology:
Cellular Component:	spindle [IDA] condensed nuclear chromosome kinetochore [IDA] kinetochore [IDA]
Biological Process:	mitotic spindle organization in nucleus [IGI ][IMP ] meiosis [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEVPTTPVR LILGQAQQRE QNSENCSQER NPRTFNSEPD SSFNSPGSSQ FVIHPHEPLE  60
   61 KEKDEKQDLD RSIDYGRSSA LNNKNNANPL ENIDINKMFD DKKSDSGTND DKGGASTSDK 120
  121 HVLALNYSPI RVEMNSSEKR SDKNVDVDEN DKEGSHINKK LKLQLESVPD LKQSSTKDII 180
  181 NDKEEIMSSP MAIDMIETNI SPNKFIINDG VERNDSFNIN TDTLKLENDI NEKQQEEDFI 240
  241 KSNSNNVVNI DNAYKEKEDE ENDITNSHIN RLTPLYETSA RESNSNEEGR NDYDDDNQLD 300
  301 IRHDNFQIVA KRNEELTDQI YHLNQMLNSL ISKNESLSFQ YEKLNKNHQL LIDLTNEKLD 360
  361 KLNTERESDI AKVEKFKKRI KELNTEIKVL NSNQKILQEK FDASITEVNH IKGEHENTVN 420
  421 TLQQNEKILN DKNVELENMK AELKGNNDKL SEYETTLNDL NSRIVQLNDK IESTDIVLKS 480
  481 KENELDNLKL SLKETLSISK DFNDSDLIGQ INELISTKNN LQQKMDDLNN LNDDNLKVVQ 540
  541 DKLIKNEETL KLKEAEIDSL NSEMDELKKQ ITSKDDEFKM WQSKYETVED EAKIRNAEVT 600
  601 ELNGDIEDLK ESKLHLEETI TELENKVHKL ENECELEKQK FEKTSLELES LQLKNSNIQA 660
  661 EHIKELENLH ENLISLQNEL KISSDRITTL TKENEVLMEQ NNNNNNSVTL SNDQKDRDDE 720
  721 KIKSLGKQVQ DWKEKYEAKE KDTNKRLKLL AEDLYIQYSS KHEQKVKLLK KGYENKYQNK 780
  781 FDQLNLENKT LSEEIEQLNK QLSSEREEKQ ELLKLLENEK K

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		AIM3 BAR1 COA4 GYL1 GYP5 HNT1 KIN2 MEF2 NCP1 PCL10 PRP28 RVS161 RVS167 SAE2 SLK19 TIM21 VPS15
View Details	Qiu et al. (2008)		BIK1 BUB1 CIK1 KAR3 NUF2 SLK19 SPC110 STU1 STU2 TID3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	IPL1	No Comments	Cheeseman IM, et al. (2002)
View Run	SLK19	No Comments	Cheeseman IM, et al. (2002)
View Run	PAN1	No Comments	Toshima J, et al (2006)
View Run	PAN1	No Comments	Toshima J, et al (2006)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SLK19	Sundin BA, et al. (2004)
View Data	SLK19	Sundin BA, et al. (2004)
View Data	SLK19 and SPC42	Huh WK, et al. (2003)
View Data	SLK19	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..458]	PSI-BLAST	33.69897	Heavy meromyosin subfragment
2	View Details	[459..552]	PSI-BLAST	11.09691	Tropomyosin
3	View Details	[553..655]	PSI-BLAST	11.09691	Tropomyosin
4	View Details	[656..821]	MSA	14.223995	View MSA. No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: SLK19

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: