Protein Overview: CUS2

General Information:
Name(s) found:	CUS2 / YNL286W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324043\|ref\|NP_014113.1\| Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs); Cus2p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S63260 hypothetical protein YNL286w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1730649\|sp\|P53830.1\|YN26_YEAST RecName: Full=Uncharacterized RNA-binding protein YNL286W [NCBI NR] gi\|1302367\|emb\|CAA96203.1\| CUS2 [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized RNA-binding protein YNL286W OS=Saccharomyces cerevisiae GN=YNL286W PE=1 SV=1 [Swiss-Prot] CUS2 Cold sensitive U2 snRNA Suppressor [mips] Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) [SGD] Chr XIV from 95221-96078 [yeastorf3.fasta] (P53830) Hypothetical 32.3 kDa protein in SEC21-MRPL10 intergenic region [4932.FASTACCERV.txt] CUS2, Chr XIV from 95221-96078 [yeast_orfs2] CUS2 SGDID:S0005230, Chr XIV from 95221-96078, Verified ORF [yeastflysequest.fasta] Cus2p [Saccharomyces cerevisiae]gi\|1302367\|emb\|CAA96203.1\| CUS2 [Saccharomyces cerevisiae]gi\|2131956\|pir\|\|S63260 hypothetical protein YNL286w - yeast (Saccharomyces cerevisiae)gi\|1730649\|sp\|P53830\|YN26_YEAST Hypothetical 32.3 kDa protein in SEC21-MRPL1 [nrdb_11152004_Chlamydomonas] CUS2 SGDID:S000005230, Chr XIV from 95223-96080, Verified ORF, "Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CUS2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Probable RNA-binding protein YNL286W [nr-271106-contam.fasta] Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs); Cus2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] CUS2 SGDID:S000005230, Chr XIV from 95223-96080, Genome Release 64-1-1, Verified ORF, "Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)" [yeast-030211-contam.fasta] CUS2 SGDID:S000005230, Chr XIV from 95223-96080, Genome Release 64-2-1, Verified ORF, "Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)" [20141208_orf_trans.fasta] TR7049\|c1_g1_i1\|g.4892 ORF TR7049\|c1_g1_i1\|g.4892 TR7049\|c1_g1_i1\|m.4892 type:complete len:286 (+) TR7049\|c1_g1_i1:139-996(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR6532\|c0_g1_i1\|g.4729 ORF TR6532\|c0_g1_i1\|g.4729 TR6532\|c0_g1_i1\|m.4729 type:complete len:286 (+) TR6532\|c0_g1_i1:123-980(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YNL286W SGDID:S000005230, Chr XIV from 95223-96080, Genome Release 64-1-1, Verified ORF, "Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_5457\|g.3791 ORF asmbl_5457\|g.3791 asmbl_5457\|m.3791 type:complete len:286 (+) asmbl_5457:122-979(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_5454\|g.3586 ORF ID=asmbl_5454\|g.3586 ID=asmbl_5454\|m.3586 type:complete len:286 (+) ID=asmbl_5454:122-979(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_9743\|g.5896 ORF ID=asmbl_9743\|g.5896 ID=asmbl_9743\|m.5896 type:complete len:286 (+) ID=asmbl_9743:3421-4278(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	285 amino acids
Gene Ontology:
Cellular Component:	U2 snRNP [IDA]
Biological Process:	nuclear mRNA splicing, via spliceosome [IGI][IPI]
Molecular Function:	RNA binding [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDADELELKG HLKKLKKEEL LRRKQLKESN LQKRELEYNN ASKNTSIYIS GLPTDKTTKE  60
   61 GLTEQFCKYG MIRTNRDGEP LCKLYVNDKG AFKGDALITY SKEESVTLAI EMMNESIFLG 120
  121 KQIRVERAQF QNKEGDNMHG KENDLKEFNG PEPPIKRLKK AKSEGEGEVI DYNDDESLAK 180
  181 ADRTVIFANV FNIYKSYTND DINDIQEDLL EGCEEIGQVD SISVSPNKGE ATVVFKNNKV 240
  241 ALQCCKIMTG RYFDGQKLLA FISGDENTSS TSDKNEDSEV EDDLI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		CUS2 SPP2
View Details	Qiu et al. (2008)		BRR1 BRR2 CBC2 CEF1 CUS1 CUS2 CWC2 CWC25 DIB1 HSH155 IST3 ISY1 LEA1 LSM3 LSM4 LUC7 MSL1 MUD1 MUD2 NAM8 PRP11 PRP16 PRP18 PRP2 PRP21 PRP24 PRP28 PRP31 PRP39 PRP4 PRP40 PRP42 PRP43 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SUB2 SYF2 YHC1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	CUS2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..130]	PSI-BLAST	29.69897	Poly(A)-binding protein
2	View Details	[131..285]	PSI-BLAST	29.69897	Poly(A)-binding protein

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: CUS2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: