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Protein Overview: PSY2

General Information:
Name(s) found: PSY2 / YNL201C [SGD]
Description(s) found:
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  • gi|732193|sp|P40164.1|PP4R3_YEAST RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 3; Short=PP4R3 [NCBI NR]
  • gi|6324128|ref|NP_014198.1| Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus; Psy2p [NCBI NR]
  • gi|600064|emb|CAA55507.1| N1366 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50730 hypothetical protein YNL201c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1302202|emb|CAA96100.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P40164) Hypothetical 98.1 kDa protein in SPX19-GCR2 intergenic region [Swiss-Prot]
  • Serine/threonine-protein phosphatase 4 regulatory subunit 3 OS=Saccharomyces cerevisiae GN=PSY2 PE=1 SV=1 [Swiss-Prot]
  • PSY2 Platinum SensitivitY protein [mips]
  • Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; putative homolog of mammalian R3 [SGD]
  • Chr XIV from 260624-263200, reverse complement [yeastorf3.fasta]
  • Chr XIV from 263200-260624, reverse complement [yeastorf5.fasta]
  • YNL201C, Chr XIV from 260624-263200, reverse complement [yeast_orfs2]
  • PSY2 SGDID:S0005145, Chr XIV from 263202-260626, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • Nuclear protein of unknown function; deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin, but not mitomycin C; deletion is synthetically lethal with a chitin synthase (CHS1) null mutant [Saccharomyces cerevisiae]gi|600064|emb|CA [nrdb_11152004_Chlamydomonas]
  • PSY2 SGDID:S000005145, Chr XIV from 263204-260628, reverse complement, Uncharacterized ORF, "Nuclear protein of unknown function; deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin, but not mitomycin C; deletion is synthetically [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PSY2 SGDID:S000005145, Chr XIV from 263204-260628, reverse complement, Verified ORF, "Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplat [yeast-contam.fasta]
  • Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus; Psy2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Serine/threonine-protein phosphatase 4 regulatory subunit 3 (PP4R3) [nr-271106-contam.fasta]
  • N1366 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PSY2 SGDID:S000005145, Chr XIV from 263204-260628, reverse complement, Verified ORF, "Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; putative homolog of mammalian R3" [yeast-bovrabprots.fasta]
  • PSY2 SGDID:S000005145, Chr XIV from 263204-260628, reverse complement, Verified ORF, "Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Serine/threonine-protein phosphatase 4 regulatory subunit 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PSY2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PSY2 SGDID:S000005145, Chr XIV from 263203-260627, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3" [yeast-030211-contam.fasta]
  • PSY2 SGDID:S000005145, Chr XIV from 263203-260627, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3" [20141208_orf_trans.fasta]
  • YNL201C SGDID:S000005145, Chr XIV from 263203-260627, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 858 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    response to DNA damage stimulus [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPGTPTTS PTPMDEDTEQ AVSVNTEPKR VKVYILENNE WKDTGTGFCI GEVDEGKFAY  60
   61 LVVSDEDSPT ETLLKSKLEG NIEYQRQEET LIVWKDLGGK DIALSFEESM GCDTLCEFIV 120
  121 HVQRNIESNI SLVTVKSSDN GLGSVHDIIT GPVTLPSNDQ QQNSQTLLEA LKILNENTSF 180
  181 DFLKNETIEF ILQSNYIDTL ISHFHKAEEE KIPKDLFLLS NIIKTLILYN KRDILESMVE 240
  241 DDRIMGIVGI LEYDTEYPTS KANHRKYLGS KGPNFKEVIP LENEDLKIIM KKCFRLQFLK 300
  301 DVVLVRFLDD HNFNLISEIV MDLETCIIDF LQVGTFLDRL IELYDTKTLP ESSSEKEKFV 360
  361 QKRKDGIRLL QQCVQMSINL DAVDRSKFYK TLVRKGLFKV LDYAFHMETD SNVRILATDT 420
  421 IITIIEHDIL LIHNVQNEDS FKRQHKSAPD DKSSHRKYPQ DYSSSTDSKL LLILSTILLS 480
  481 DRSPGLREQV VQALNTLLHP EGCVGNGEGS YDLMGRSNYE AKNTSEDFPS FSYGLNSDSI 540
  541 NLNNYHYSSD EMNNLEPESE SEFQVMEYFA NFYNKIAPIL FGPLIKKDIT TEMAEIDGQI 600
  601 EKVTKDDLLL IHLVKLVSFV CTEHDRVLSR RFILENGILD SVSKLIGGNH MMQLRLTAVR 660
  661 CIKNLMCLDD KYYHRYMISK NLYAPVFKLF QENIDKNNLA NSCIQDFFRI IITECRAYQS 720
  721 DGHNRKEKTN GSYDGNGNDV KTNVNNNRTN FTILNKYLVQ TYGDVLRKAT DIPFIQDMLE 780
  781 TGEENQPDHS SFENSIEGGN DISVNMSTDG FASNHLEDID IKNVKRLHSE IEHFENDPHY 840
  841 SGDQLAFKKS VDQMNAST

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) KAP114 PPH3 PSY2 PSY4 SPT5 SSD1
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2
    View Details Gavin AC, et al. (2006) PPH3 PSY2 PSY4
    View Details Gavin AC, et al. (2002) BEM2 PPH3 PSY2 PSY4 RGA2 SPT5 TDH3 TRM3
    View Details Ho Y, et al. (2002) ARO1 BCK1 CCT2 CCT3 CHS1 CMP2 DBP7 DIA4 KOG1 KSP1 PPH3 PRI2 PSY2 PSY4 STE12 TCP1 TPD3 YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PHO85 PSY2 2 Uetz P, et al. (2000)
    View Screen RAD53 PSY2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PSY2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] ab initio 7.92 No description for 1i2hA was found.
    2 View Details [163..241] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [242..534] MSA 2.015931 View MSA. No confident structure predictions are available.
    4 View Details [535..599] deduced N/A No confident structure predictions are available.
    5 View Details [600..718] MSA 2.011971 View MSA. Confident ab initio structure predictions are available.
    6 View Details [719..858] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle