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Protein Overview: VTI1

General Information:
Name(s) found: VTI1 / YMR197C [SGD]
Description(s) found:
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  • gi|642290|emb|CAA87819.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323853|ref|NP_013924.1| Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; Vti1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2497184|sp|Q04338.3|VTI1_YEAST RecName: Full=t-SNARE VTI1; AltName: Full=Qb-SNARE VTI1; AltName: Full=Vesicle transport v-SNARE protein VTI1; AltName: Full=VPS10-interacting protein 1 [NCBI NR]
  • gi|2226090|gb|AAC49745.1| Vti1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50926 VTI1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • t-SNARE VTI1 OS=Saccharomyces cerevisiae GN=VTI1 PE=1 SV=3 [Swiss-Prot]
  • VTI1 V-SNARE: involved in Golgi retrograde protein traffic [mips]
  • Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways [SGD]
  • VTI1, Chr XIII from 658544-659197, reverse complement [yeast_orfs2]
  • Chr XIII from 658544-659197, reverse complement [yeastorf3.fasta]
  • Chr XIII from 659197-658544, reverse complement [yeastorf5.fasta]
  • (Q04338) Vesicle transport v-SNARE protein VTI1 [4932.FASTACCERV.txt]
  • VTI1 SGDID:S0004810, Chr XIII from 659197-658544, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Involved in cis-Golgi membrane traffic; Vti1p is a v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p [Saccharomyces cerevisiae]gi|642290|emb|CAA87819.1| unknown [Saccharomyces cerevisiae]gi|2497184|sp|Q04338|VTI1_YEAST Vesicle transport v-SNARE [nrdb_11152004_Chlamydomonas]
  • VTI1 SGDID:S000004810, Chr XIII from 659197-658544, reverse complement, Verified ORF, "Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • t-SNARE VTI1 (Qb-SNARE VTI1) (Vesicle transport v-SNARE protein VTI1) (VPS10-interacting protein 1) [nr-271106-contam.fasta]
  • Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; Vti1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Vti1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • t-SNARE VTI1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VTI1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • VTI1 SGDID:S000004810, Chr XIII from 659198-658545, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways" [yeast-030211-contam.fasta]
  • VTI1 SGDID:S000004810, Chr XIII from 659198-658545, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways" [20141208_orf_trans.fasta]
  • YMR197C SGDID:S000004810, Chr XIII from 659198-658545, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 217 amino acids

    Gene Ontology:
    Cellular Component: integral to Golgi membrane [IDALink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    intra-Golgi vesicle-mediated transport [TASLink to PubMed article]
    endosome to lysosome transport [TASLink to PubMed article]
    Golgi to vacuole transport [TASLink to PubMed article]
    Molecular Function: receptor signaling protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLLISYES DFKTTLEQAK ASLAEAPSQP LSQRNTTLKH VEQQQDELFD LLDQMDVEVN  60
   61 NSIGDASERA TYKAKLREWK KTIQSDIKRP LQSLVDSGDR DRLFGDLNAS NIDDDQRQQL 120
  121 LSNHAILQKS GDRLKDASRI ANETEGIGSQ IMMDLRSQRE TLENARQTLF QADSYVDKSI 180
  181 KTLKTMTRRL VANKFISYAI IAVLILLILL VLFSKFK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) VTI1 YKT6
    View Details (MIPS) Mewes HW, et al. (2004) BET1 BOS1 GOS1 NYV1 SEC22 SNC1 SNC2 VTI1
    View Details Gavin AC, et al. (2006) PEP12 SEC17 VTI1 YKT6
    View Details Gavin AC, et al. (2002) SEC17 SLY1 TLG1 TLG2 VPS45 VTI1 YKT6
    View Details Qiu et al. (2008) BOS1 COG7 GGA1 GOS1 NYV1 PEP12 SEC20 SEC22 SED5 SFT1 SNC1 SNC2 SSO1 TLG1 TLG2 UFE1 VAM7 VPS45 VTI1 YOS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run VAM3 sample: hx1 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx2 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] PSI-BLAST 4.0 Heavy meromyosin subfragment
    2 View Details [122..217] PSI-BLAST 27.071898 Vesicle ransport v-SNARE protein VTI1b


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle