Protein Overview: YAP1

General Information:
Name(s) found:	YAP1 / YML007W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|854483\|emb\|CAA89945.1\| Pdr4p [Saccharomyces cerevisiae] [NCBI NR] gi\|6323636\|ref\|NP_013707.1\| Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance t [NCBI NR] gi\|4506\|emb\|CAA44917.1\| SNQ3 [Saccharomyces cerevisiae] [NCBI NR] gi\|417456\|sp\|P19880.2\|YAP1_YEAST RecName: Full=AP-1-like transcription factor YAP1; AltName: Full=Phenanthroline resistance protein PAR1; AltName: Full=Pleiotropic drug resistance protein PDR4 [NCBI NR] pir\|\|S16706 transcription activator YAP1 - yeast (Saccharomyces cerevisiae) [NCBI NR] AP-1-like transcription factor YAP1 OS=Saccharomyces cerevisiae GN=YAP1 PE=1 SV=2 [Swiss-Prot] YAP1 Transcriptional activator involved in oxidative stress response [mips] Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium [SGD] YAP1, Chr XIII from 253848-255800 [yeast_orfs2] Chr XIII from 253848-255800 [yeastorf3.fasta] (P19880) Transcriptional activator PDR4 (YAP-1 protein) [4932.FASTACCERV.txt] YAP1 SGDID:S0004466, Chr XIII from 253848-255800, Verified ORF [yeastflysequest.fasta] Yap1p [Saccharomyces cerevisiae]gi\|854483\|emb\|CAA89945.1\| Pdr4p [Saccharomyces cerevisiae]gi\|4506\|emb\|CAA44917.1\| SNQ3 [Saccharomyces cerevisiae]gi\|101360\|pir\|\|S16706 transcription activator YAP1 - yeast (Saccharomyces cerevisiae)gi\|417456\|sp\|P19880\|Y [nrdb_11152004_Chlamydomonas] (P19880) AP-1 like transcription factor YAP1 (Phenanthroline resistance protein PAR1) (Pleiotropic drug resistance protein PDR4) [cerv4932.FASTAC] YAP1 SGDID:S000004466, Chr XIII from 253848-255800, Verified ORF, "Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presen [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YAP1 SGDID:S000004466, Chr XIII from 253848-255800, Verified ORF, "Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplas [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Pdr4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] AP-1-like transcription factor YAP1 (Phenanthroline resistance protein PAR1) (Pleiotropic drug resistance protein PDR4) [nr-271106-contam.fasta] Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxidants; Yap1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SNQ3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YAP1 SGDID:S000004466, Chr XIII from 253848-255800, Verified ORF, "Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium" [yeast-bovrabprots.fasta] YAP1 SGDID:S000004466, Chr XIII from 253848-255800, Verified ORF, "Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxidants" [yeast-contam_custom.fasta] [chemostatdb.fasta] AP-1-like transcription factor YAP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YAP1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YAP1 SGDID:S000004466, Chr XIII from 253848-255800, Genome Release 64-1-1, Verified ORF, "Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium" [yeast-030211-contam.fasta] YAP1 SGDID:S000004466, Chr XIII from 253848-255800, Genome Release 64-2-1, Verified ORF, "Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YML007W SGDID:S000004466, Chr XIII from 253848-255800, Genome Release 64-1-1, Verified ORF, "Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	650 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA ] cytoplasm [IDA ]
Biological Process:	response to heat [IMP] transcription [IDA] response to arsenic [IEP][IMP] response to drug [IMP ] response to singlet oxygen [IMP]
Molecular Function:	transcription factor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSTAKRSL DVVSPGSLAE FEGSKSRHDE IENEHRRTGT RDGEDSEQPK KKGSKTSKKQ  60
   61 DLDPETKQKR TAQNRAAQRA FRERKERKMK ELEKKVQSLE SIQQQNEVEA TFLRDQLITL 120
  121 VNELKKYRPE TRNDSKVLEY LARRDPNLHF SKNNVNHSNS EPIDTPNDDI QENVKQKMNF 180
  181 TFQYPLDNDN DNDNSKNVGK QLPSPNDPSH SAPMPINQTQ KKLSDATDSS SATLDSLSNS 240
  241 NDVLNNTPNS STSMDWLDNV IYTNRFVSGD DGSNSKTKNL DSNMFSNDFN FENQFDEQVS 300
  301 EFCSKMNQVC GTRQCPIPKK PISALDKEVF ASSSILSSNS PALTNTWESH SNITDNTPAN 360
  361 VIATDATKYE NSFSGFGRLG FDMSANHYVV NDNSTGSTDS TGSTGNKNKK NNNNSDDVLP 420
  421 FISESPFDMN QVTNFFSPGS TGIGNNAASN TNPSLLQSSK EDIPFINANL AFPDDNSTNI 480
  481 QLQPFSESQS QNKFDYDMFF RDSSKEGNNL FGEFLEDDDD DKKAANMSDD ESSLIKNQLI 540
  541 NEEPELPKQY LQSVPGNESE ISQKNGSSLQ NADKINNGND NDNDNDVVPS KEGSLLRCSE 600
  601 IWDRITTHPK YSDIDVDGLC SELMAKAKCS ERGVVINAED VQLALNKHMN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CSE2 GAL11 MED1 MED11 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 SIN4 SRB2 SRB4 SRB5 SRB8 SSN2 SSN3 YAP1
View Details	Krogan NJ, et al. (2006)		CCZ1 MON1 YAP1
View Details	Gavin AC, et al. (2002)		ACT1 ADH1 ARP4 EAF1 EAF3 EAF5 EPL1 ESA1 HHF1, HHF2 TRA1 YAF9 YAP1
View Details	Qiu et al. (2008)		GAL11 YAP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ELM1	YAP1	1	Unpublished Fields Lab Data
View Screen	APC5	YAP1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YAP1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..187]	PSI-BLAST	62.67837	PAP1
2	View Details	[188..325]	deduced	N/A	Confident ab initio structure predictions are available.
3	View Details	[326..650]	MSA	1.004925	View MSA. No confident structure predictions are available.
4	View Details	[350..518]	deduced	N/A	No confident structure predictions are available.
5	View Details	[519..650]	PSI-BLAST	33.30103	Solution structure of the oxidized form of the Yap1 redox domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2