Protein Overview: CDC11

General Information:
Name(s) found:	CDC11 / YJR076C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322536\|ref\|NP_012610.1\| Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM [NCBI NR] pir\|\|S40911 septin CDC11 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|416760\|sp\|P32458.1\|CDC11_YEAST RecName: Full=Cell division control protein 11 [NCBI NR] gi\|295594\|gb\|AAB50035.1\| cell division cycle protein [NCBI NR] gi\|1019697\|gb\|AAB39301.1\| ORF YJR076c [NCBI NR] gi\|1015762\|emb\|CAA89604.1\| CDC11 [Saccharomyces cerevisiae] [NCBI NR] Cell division control protein 11 OS=Saccharomyces cerevisiae GN=CDC11 PE=1 SV=1 [Swiss-Prot] (P32458) Cell division control protein 11 [Swiss-Prot] CDC11 Septin [mips] Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM [SGD] CDC11, Chr X from 575046-576293, reverse complement [yeast_orfs2] Chr X from 575046-576293, reverse complement [yeastorf3.fasta] Chr X from 575047-576294, reverse complement [yeastorf4.fasta] Chr X from 576295-575048, reverse complement [yeastorf5.fasta] CDC11 SGDID:S0003837, Chr X from 576515-575268, reverse complement, Verified ORF [yeastflysequest.fasta] Cdc11p [Saccharomyces cerevisiae]gi\|1015762\|emb\|CAA89604.1\| CDC11 [Saccharomyces cerevisiae]gi\|416760\|sp\|P32458\|CC11_YEAST Cell division control protein 11gi\|482158\|pir\|\|S40911 septin CDC11 - yeast (Saccharomyces cerevisiae)gi\|295594\|gb\|AAB50035.1\| ce [nrdb_11152004_Chlamydomonas] CDC11 SGDID:S000003837, Chr X from 576515-575268, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the me [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CDC11 SGDID:S000003837, Chr X from 576594-575347, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the me [yeast-contam.fasta] CDC11 SGDID:S000003837, Chr X from 576593-575346, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the me [yeast-200209-contam.fasta] Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; Cdc11p [Saccharomyces cere [nr-271106-contam.fasta] ORF YJR076c [nr-271106-contam.fasta] cell division cycle protein [nr-271106-contam.fasta] Cell division control protein 11 [nr-271106-contam.fasta] CDC11 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CDC11 SGDID:S000003837, Chr X from 576593-575346, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM" [yeast-bovrabprots.fasta] CDC11 SGDID:S000003837, Chr X from 576594-575347, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM" [yeast-contam_custom.fasta] [chemostatdb.fasta] Cell division control protein 11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC11 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CDC11 SGDID:S000003837, Chr X from 576601-575354, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM" [yeast-030211-contam.fasta] CDC11 SGDID:S000003837, Chr X from 576601-575354, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells" [20141208_orf_trans.fasta] TR2557\|c0_g1_i1\|g.1917 ORF TR2557\|c0_g1_i1\|g.1917 TR2557\|c0_g1_i1\|m.1917 type:complete len:416 (+) TR2557\|c0_g1_i1:73-1320(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR563\|c0_g1_i1\|g.443 ORF TR563\|c0_g1_i1\|g.443 TR563\|c0_g1_i1\|m.443 type:complete len:416 (+) TR563\|c0_g1_i1:328-1575(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YJR076C SGDID:S000003837, Chr X from 576601-575354, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_5918\|g.4696 ORF asmbl_5918\|g.4696 asmbl_5918\|m.4696 type:complete len:416 (+) asmbl_5918:324-1571(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_5407\|g.4086 ORF asmbl_5407\|g.4086 asmbl_5407\|m.4086 type:complete len:416 (+) asmbl_5407:82-1329(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_5912\|g.3713 ORF ID=asmbl_5912\|g.3713 ID=asmbl_5912\|m.3713 type:complete len:416 (+) ID=asmbl_5912:324-1571(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_5409\|g.3459 ORF ID=asmbl_5409\|g.3459 ID=asmbl_5409\|m.3459 type:complete len:416 (+) ID=asmbl_5409:82-1329(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	415 amino acids
Gene Ontology:
Cellular Component:	cellular bud neck septin ring [TAS] prospore membrane [TAS] ascospore wall [TAS] mating projection base [IDA]
Biological Process:	axial cellular bud site selection [TAS] cell morphogenesis [TAS] conjugation with cellular fusion [TAS] cellular cell wall organization [TAS] cytokinesis [TAS]
Molecular Function:	structural constituent of cytoskeleton [TAS] phosphatidylinositol binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGIIDASSA LRKRKHLKRG ITFTVMIVGQ SGSGRSTFIN TLCGQQVVDT STTILLPTDT  60
   61 STEIDLQLRE ETVELEDDEG VKIQLNIIDT PGFGDSLDNS PSFEIISDYI RHQYDEILLE 120
  121 ESRVRRNPRF KDGRVHCCLY LINPTGHGLK EIDVEFIRQL GSLVNIIPVI SKSDSLTRDE 180
  181 LKLNKKLIME DIDRWNLPIY NFPFDEDEIS DEDYETNMYL RTLLPFAIIG SNEVYEMGGD 240
  241 VGTIRGRKYP WGILDVEDSS ISDFVILRNA LLISHLHDLK NYTHEILYER YRTEALSGES 300
  301 VAAESIRPNL TKLNGSSSSS TTTRRNTNPF KQSNNINNDV LNPASDMHGQ STGENNETYM 360
  361 TREEQIRLEE ERLKAFEERV QQELLLKRQE LLQREKELRE IEARLEKEAK IKQEE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CDC10 CDC11 CDC12 CDC3 SHS1
View Details	(MIPS) Mewes HW, et al. (2004)		CDC10 CDC11 CDC12 CDC3 SHS1 SPR28 SPR3
View Details	Krogan NJ, et al. (2006)		CDC10 CDC11 CDC12 CDC3 CDC37 SHS1
View Details	Gavin AC, et al. (2006)		BUD4 CDC10 CDC11 CDC12 CDC3 SHS1
View Details	Gavin AC, et al. (2002)		ACE2 ALT2 BCK1 CDC10 CDC11 CDC12 CDC3 DRE2 ECM30 ENP2 IML1 MNL1 MTR4 MYO2 RGC1 SEC3 SHS1 UBP15 YBL044W YJR098C YNL313C
View Details	Ho Y, et al. (2002)		AAT2 ARC1 CDC10 CDC11 CDC12 CDC3 CLU1 HOM2 LPD1 PDI1 RPN1 SHS1 THR4 TIF4631 TIF4632 TOP2 YHR033W
View Details	Qiu et al. (2008)		ACT1 AXL2 BEM1 BNI4 BNI5 BUD4 CDC10 CDC11 CDC12 CDC3 HOF1 IQG1 PXL1 SHO1 SHS1 SPR28 SPR3 TPM2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	BOI1	Sample boi 1 with ha tag from october 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC12	CDC11	2	Drees BL, et al. (2001)
View Screen	CDC11	SPR28	2	Drees BL, et al. (2001)
View Screen	CDC11	CDC12	2	Drees BL, et al. (2001)
View Screen	CDC11	NFI1	2	Drees BL, et al. (2001)
View Screen	CDC11	HUA2	2	Unpublished Fields Lab Data
View Screen	ZDS2	CDC11	2	Drees BL, et al. (2001)
View Screen	BEM4	CDC11	2	Drees BL, et al. (2001)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CDC11	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..175]	PSI-BLAST	7.09691	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
2	View Details	[176..415]	PSI-BLAST	3.69897	Heavy meromyosin subfragment

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.33

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2