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Protein Overview: IME2

General Information:
Name(s) found: IME2 / YJL106W [SGD]
Description(s) found:
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  • gi|728704|emb|CAA59388.1| SME1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6322355|ref|NP_012429.1| Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; Ime2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|4496|emb|CAA37351.1| protein kinase homologue [Saccharomyces cerevisiae] [NCBI NR]
  • gi|417780|sp|P32581.1|IME2_YEAST RecName: Full=Meiosis induction protein kinase IME2/SME1 [NCBI NR]
  • pir||S20138 probable protein kinase SME1 (EC 2.7.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1008288|emb|CAA89401.1| IME2 [Saccharomyces cerevisiae] [NCBI NR]
  • Meiosis induction protein kinase IME2/SME1 OS=Saccharomyces cerevisiae GN=IME2 PE=1 SV=1 [Swiss-Prot]
  • IME2 Ser/thr protein kinase [mips]
  • Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p [SGD]
  • IME2, Chr X from 221087-223024 [yeast_orfs2]
  • Chr X from 221087-223024 [yeastorf3.fasta]
  • (P32581) Meiosis induction protein kinase IME2/SME1 (EC 2.7.1.-) [4932.FASTACCERV.txt]
  • IME2 SGDID:S0003642, Chr X from 221307-223244, Verified ORF [yeastflysequest.fasta]
  • Ime2p [Saccharomyces cerevisiae]gi|1008288|emb|CAA89401.1| IME2 [Saccharomyces cerevisiae]gi|4496|emb|CAA37351.1| protein kinase homologue [Saccharomyces cerevisiae]gi|728704|emb|CAA59388.1| SME1 [Saccharomyces cerevisiae]gi|417780|sp|P32581|IME2_YEAS [nrdb_11152004_Chlamydomonas]
  • IME2 SGDID:S000003642, Chr X from 221307-223244, Verified ORF, "Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • IME2 SGDID:S000003642, Chr X from 221386-223323, Verified ORF, "Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p" [yeast-contam.fasta]
  • IME2 SGDID:S000003642, Chr X from 221385-223322, Verified ORF, "Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p" [yeast-200209-contam.fasta]
  • IME2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Meiosis induction protein kinase IME2/SME1 [nr-271106-contam.fasta]
  • SME1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; Ime2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • protein kinase homologue [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Meiosis induction protein kinase IME2/SME1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IME2 PE=2 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • IME2 SGDID:S000003642, Chr X from 221390-223327, Genome Release 64-1-1, Verified ORF, "Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p" [yeast-030211-contam.fasta]
  • Meiosis induction protein kinase IME2/SME1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IME2 PE=3 SV=1 [YEAST.fasta.20131015]
  • IME2 SGDID:S000003642, Chr X from 221390-223327, Genome Release 64-2-1, Verified ORF, "Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p" [20141208_orf_trans.fasta]
  • YJL106W SGDID:S000003642, Chr X from 221390-223327, Genome Release 64-1-1, Verified ORF, "Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 645 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: regulation of meiosis [IMPLink to PubMed article]
    protein amino acid phosphorylation [TASLink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEKRSRQSS SSGSEFSVPP DVDNPPLSIP LKTLSDRYQL IEKLGAGSFG CVTLAKAQFP  60
   61 LSNILGKQHD IRGTLMDQPK NGHQNYITKT QGVVAIKTMM TKLHTLQDYT RVREIKFILA 120
  121 IPANDHLIQI FEVFIDSENY QLHIVMECME QNLYQMMKHR RRRVFSIPSL KSILSQILAG 180
  181 LKHIHEHNFF HRDLKPENIL ITPSTQYFEK EYMNQIGYQD NYVIKLADFG LARHVENKNP 240
  241 YTAYVSTRWY RSPEILLRSG YYSKPLDIWA FGCVAVEVTV FRALFPGANE IDQIWKILEV 300
  301 LGTPIKRSDF VNTNHITAPP PGGFWDDASN LVHKLNLKLP YVEGSSLDHL LSSSQLSDLS 360
  361 EVVKKCLRWD PNERATAQEL CEMPFFENTV ASQVDARGNV TNTEQALIFA GINPVATNTK 420
  421 PIYFNSSTKL PAETESNDID ISNNDHDSHA MCSPTLNQEK LTLVEFLNEF VEEDNDDHSI 480
  481 PDVGTDSTIS DSIDETELSK EIRNNLALCQ LPDEEVLDHS LSNIRQLTND IEIINKDEAD 540
  541 NMEQLFFDLE IPEKDEFQRK QPFNEHADID EDIVLPYVNN SNYTHTDRSH HRGDNVLGDA 600
  601 SLGDSFNSMP DFTPRNFLIP TLKKSREKFE PHLSNSNQHF GNVTF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CCT2 IME2 TCP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] PSI-BLAST 472.218487 Cyclin-dependent PK, CDK2
    2 View Details [149..245]
    [388..431]    		 PSI-BLAST 472.218487 Cyclin-dependent PK, CDK2
    3 View Details [246..296] PSI-BLAST 472.218487 Cyclin-dependent PK, CDK2
    4 View Details [297..387] PSI-BLAST 472.218487 Cyclin-dependent PK, CDK2
    5 View Details [432..645] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.68265749805481 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • structural molecule activity
    		•  3.82327979736517 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.41610417530517 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.93176092222748 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.90354666768303 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • signal transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.71452519680794 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.27184436658773 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.16693359879454 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.0383359654359 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.01340572255694 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.913893847407112 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.821371946077904 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • receptor activity
    		•  0.775180603313375 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.63080698970012 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • cyclin-dependent protein kinase activating kinase activity
    		•  0.529121666062889 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.470448662251808 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.461392047923247 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.406297251827056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • RNA binding
    		•  0.245748631571068 bayes_pls_golite062009
  • cation channel activity
    		•  0.245400615103891 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.114318824149111 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle