YRC Public Data Repository - Protein Structure Prediction

Protein:	IME2
Organism:	Saccharomyces cerevisiae
Length:	645 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IME2.

Description	E-value	Query Range	Subject Range
IME2_YEAST - Meiosis induction protein kinase IME2/SME1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ... IME2 - Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediate...	0.0	[1..645]	[1..645]
gi\|7385125 - gi\|7385125\|gb\|AAF61706.1\|AF226711_1 MAP kinase [Kluyveromyces lactis]	0.0	[27..567]	[14..499]
MPK4_ARATH - Mitogen-activated protein kinase 4 OS=Arabidopsis thaliana GN=MPK4 PE=1 SV=2	0.0	[11..436]	[9..376]
MMK1_MEDSA - Mitogen-activated protein kinase homolog MMK1 OS=Medicago sativa GN=MMK1 PE=1 SV=1	0.0	[20..433]	[36..384]
NTF4_TOBAC - Mitogen-activated protein kinase homolog NTF4 OS=Nicotiana tabacum GN=NTF4 PE=2 SV=1	0.0	[20..433]	[41..389]
gi\|7649153 - gi\|7649153\|gb\|AAF65766.1\|AF242308_1 mitogen-activated protein kinase [Euphorbia esula]	0.0	[20..433]	[37..385]
MPK_PEA - Mitogen-activated protein kinase homolog D5 OS=Pisum sativum PE=2 SV=1	0.0	[20..433]	[43..391]
gi\|5007038 - gi\|5007038\|gb\|AAD37790.1\|AF149424_1 MAP kinase [Ipomoea batatas]	0.0	[20..432]	[15..362]

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Predicted Domain #1

Region A:
Residues: [1-148]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEKRSRQSS SSGSEFSVPP DVDNPPLSIP LKTLSDRYQL IEKLGAGSFG CVTLAKAQFP  60
   61 LSNILGKQHD IRGTLMDQPK NGHQNYITKT QGVVAIKTMM TKLHTLQDYT RVREIKFILA 120
  121 IPANDHLIQI FEVFIDSENY QLHIVMEC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	472.218487
Match:	1aq1__
Description:	Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	5.68265749805481	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cyclin-dependent protein kinase activity	4.62392503670521	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
structural molecule activity	3.82327979736517	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
phosphoinositide 3-kinase binding	2.41610417530517	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
cation transmembrane transporter activity	1.93176092222748	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
ion transmembrane transporter activity	1.90354666768303	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
molecular transducer activity	1.79921740914853	bayes_pls_golite062009
signal transducer activity	1.79921740914853	bayes_pls_golite062009
telethonin binding	1.75733591474207	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.71452519680794	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
MAP kinase kinase activity	1.42275431028856	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
actin binding	1.33479685165255	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.27184436658773	bayes_pls_golite062009
insulin receptor activity	1.22442673174261	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
acetylcholine receptor activator activity	1.16693359879454	bayes_pls_golite062009
transcription repressor activity	1.14496167267281	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
fibroblast growth factor 1 binding	1.0383359654359	bayes_pls_golite062009
fibroblast growth factor receptor activity	1.01340572255694	bayes_pls_golite062009
transcription activator activity	0.997272622653026	bayes_pls_golite062009
PTB domain binding	0.9900774724568	bayes_pls_golite062009
transmembrane receptor activity	0.913893847407112	bayes_pls_golite062009
alpha-actinin binding	0.877087652539674	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.872782211382796	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.821371946077904	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
receptor activity	0.775180603313375	bayes_pls_golite062009
JUN kinase kinase kinase activity	0.63080698970012	bayes_pls_golite062009
insulin binding	0.614254468447749	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
transporter activity	0.595111702412257	bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity	0.529121666062889	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
fibroblast growth factor binding	0.470448662251808	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.461392047923247	bayes_pls_golite062009
kinase binding	0.443916188551908	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
transmembrane transporter activity	0.41384976209545	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	0.406297251827056	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.401250804041384	bayes_pls_golite062009
structural constituent of muscle	0.399773397398032	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
structure-specific DNA binding	0.318153468064373	bayes_pls_golite062009
protein kinase binding	0.285611963740145	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
RNA binding	0.245748631571068	bayes_pls_golite062009
cation channel activity	0.245400615103891	bayes_pls_golite062009
actin filament binding	0.2403700250846	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.114318824149111	bayes_pls_golite062009
substrate-specific transporter activity	0.0922946791401962	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [149-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQNLYQMMK HRRRRVFSIP SLKSILSQIL AGLKHIHEHN FFHRDLKPEN ILITPSTQYF  60
   61 EKEYMNQIGY QDNYVIKLAD FGLARHVENK NPYTAYV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [388-431]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTVASQVDAR GNVTNTEQAL IFAGINPVAT NTKPIYFNSS TKLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	472.218487
Match:	1aq1__
Description:	Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [246-296]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STRWYRSPEI LLRSGYYSKP LDIWAFGCVA VEVTVFRALF PGANEIDQIW K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	472.218487
Match:	1aq1__
Description:	Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [297-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILEVLGTPIK RSDFVNTNHI TAPPPGGFWD DASNLVHKLN LKLPYVEGSS LDHLLSSSQL  60
   61 SDLSEVVKKC LRWDPNERAT AQELCEMPFF E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	472.218487
Match:	1aq1__
Description:	Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [432-645]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AETESNDIDI SNNDHDSHAM CSPTLNQEKL TLVEFLNEFV EEDNDDHSIP DVGTDSTISD  60
   61 SIDETELSKE IRNNLALCQL PDEEVLDHSL SNIRQLTNDI EIINKDEADN MEQLFFDLEI 120
  121 PEKDEFQRKQ PFNEHADIDE DIVLPYVNNS NYTHTDRSHH RGDNVLGDAS LGDSFNSMPD 180
  181 FTPRNFLIPT LKKSREKFEP HLSNSNQHFG NVTF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: