Protein Overview: COX5B

General Information:
Name(s) found:	COX5B / YIL111W [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth [SGD]
Organism:	Saccharomyces cerevisiae
Length:	151 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial respiratory chain complex IV [IDA]
Biological Process:	mitochondrial electron transport, cytochrome c to oxygen [IDA]
Molecular Function:	cytochrome-c oxidase activity [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTSLTKGA RLTGTRFVQT KALSKATLTD LPERWENMPN LEQKEIADNL TERQKLPWKT  60
   61 LNNEEIKAAW YISYGEWGPR RPVHGKGDVA FITKGVFLGL GISFGLFGLV RLLANPETPK 120
  121 TMNREWQLKS DEYLKSKNAN PWGGYSQVQS K

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		ATP14 ATP15 ATP17 ATP2 ATP3 ATP4 ATP6 ATP7 ATP8 COB COR1 COX1 COX13 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYC7 CYT1 MCR1 NDI1 OLI1 QCR10 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1 SDH1 SDH2 SDH3 SDH4 TAZ1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ELM1	COX5B	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	COX5B	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..151]	PSI-BLAST	34.0	Mitochondrial cytochrome c oxidase subunit IV

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
cytochrome-c oxidase activity	12.8672436325695	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors	12.8672436325695	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	12.8672436325695	bayes_pls_golite062009
heme-copper terminal oxidase activity	12.5536631591417	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	6.39367011108548	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	6.23942388461757	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	5.62960572959435	bayes_pls_golite062009
oxidoreductase activity	5.40847023303734	bayes_pls_golite062009
cation transmembrane transporter activity	5.36812403817205	bayes_pls_golite062009
ion transmembrane transporter activity	5.16334360779969	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.74071132470389	bayes_pls_golite062009
substrate-specific transporter activity	4.53098112436118	bayes_pls_golite062009
binding	1.89752801758092	bayes_pls_golite062009
protein binding	1.46604940289928	bayes_pls_golite062009
catalytic activity	0.600497727931764	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2