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Protein Overview: DMA1

General Information:
Name(s) found: DMA1 / YHR115C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr. [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 416 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IGILink to PubMed article]
    establishment of mitotic spindle orientation [IGILink to PubMed article]
    septin ring assembly [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNTVPSSP PNQTPPAASG IATSHDHTKF NNPIRLPISI SLTINDTPNN NSNNNSVSNG  60
   61 LGILPSRTAT SLVVANNGSA NGNVGATAAA AATVETNTAP AVNTTKSIRH FIYPPNQVNQ 120
  121 TEFSLDIHLP PNTSLPERID QSTLKRRMDK HGLFSIRLTP FIDTSSTSVA NQGLFFDPII 180
  181 RTAGAGSQII IGRYTERVRE AISKIPDQYH PVVFKSKVIS RTHGCFKVDD QGNWFLKDVK 240
  241 SSSGTFLNHQ RLSSASTTSK DYLLHDGDII QLGMDFRGGT EEIYRCVKMK IELNKSWKLK 300
  301 ANAFNKEALS RIKNLQKLTT GLEQEDCSIC LNKIKPCQAI FISPCAHSWH FHCVRRLVIM 360
  361 NYPQFMCPNC RTNCDLETTL ESESESEFEN EDEDEPDIEM DIDMEINNNL GVRLVD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) DMA1 DMA2 ERG1 RPT2 RPT4 RVB1 SKP1 STI1 UBI4 YNL311C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen DMA1 YEF1 2 Uetz P, et al. (2000)
    View Screen DMA1 CDC123 2 Uetz P, et al. (2000)
    View Screen DMA1 TFB1 1 Unpublished Fields Lab Data
    View Screen DMA1 MOB2 1 Unpublished Fields Lab Data
    View Screen DMA1 BNA6 1 Unpublished Fields Lab Data
    View Screen DMA1 CUP2 1 Unpublished Fields Lab Data
    View Screen DMA1 STV1 1 Unpublished Fields Lab Data
    View Screen DMA1 HSH155 1 Unpublished Fields Lab Data
    View Screen DMA1 PUB1 1 Unpublished Fields Lab Data
    View Screen DMA1 YOL036W 1 Unpublished Fields Lab Data
    View Screen PSF1 DMA1 1 Hazbun TR, et al. (2003)
    View Screen DMA1 NUT2 1 Unpublished Fields Lab Data
    View Screen RRP17 DMA1 1 Unpublished Fields Lab Data
    View Screen DMA1 AQY1 1 Unpublished Fields Lab Data
    View Screen MIG1 DMA1 1 Unpublished Fields Lab Data
    View Screen THG1 DMA1 1 Hazbun TR, et al. (2003)
    View Screen DMA1 SHE3 1 Unpublished Fields Lab Data
    View Screen DMA1 SLX5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DMA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118] deduced N/A No confident structure predictions are available.
    2 View Details [119..326]
    [380..416]    		 PSI-BLAST 6.0 Cbl; N-terminal domain of cbl (N-cbl); CBL
    3 View Details [327..379] PSI-BLAST 6.0 Cbl; N-terminal domain of cbl (N-cbl); CBL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • motor activity
    		•  3.25814691068414 bayes_pls_golite062009
  • binding
    		•  2.69791297400248 bayes_pls_golite062009
  • tubulin binding
    		•  2.51210014078446 bayes_pls_golite062009
  • actin binding
    		•  2.38676888633305 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.20438586677555 bayes_pls_golite062009
  • microtubule binding
    		•  2.17136406283012 bayes_pls_golite062009
  • protein binding
    		•  2.14586566310919 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.97264874084155 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.30669499755555 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.26357595913158 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.0725773039399 bayes_pls_golite062009
  • signal transducer activity
    		•  0.999269271132931 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.999269271132931 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • actin filament binding
    		•  0.836375875773328 bayes_pls_golite062009
  • structural molecule activity
    		•  0.800850121197479 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.748479359639348 bayes_pls_golite062009
  • kinase activity
    		•  0.662911740280035 bayes_pls_golite062009
  • N-terminal myristoylation domain binding
    		•  0.63045154489014 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.493362981045534 bayes_pls_golite062009
  • G-protein beta/gamma-subunit binding
    		•  0.487272307313601 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.456661966897198 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.452350351194157 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.43808715710519 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.382055332967642 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.369738999181035 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.3688716707761 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.321819287555157 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.30564870400158 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.305174269756747 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.262406945568467 bayes_pls_golite062009
  • transferase activity
    		•  0.169970258787201 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • myosin binding
    		•  0.125186564742711 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0865488336042732 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle