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View Structure Prediction Details

Protein: DMA1
Organism: Saccharomyces cerevisiae
Length: 416 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DMA1.

Description E-value Query
Range
Subject
Range
DMA1 - Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation;...
DMA1_YEAST - E3 ubiquitin-protein ligase DMA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DMA1 PE...
gi|190405894 - gi|190405894|gb|EDV09161.1| hypothetical protein SCRG_04828 [Saccharomyces cerevisiae RM11-1a]
1.0E-66 [1..416] [1..416]
gi|4959046, gi|4... - gi|4959046|gb|AAD34210.1|AF069993_1 LIM domain interacting RING finger protein [Gallus gallus], gi|4...
2.0E-39 [9..382] [214..591]
gi|9758583, gi|2... - gi|9758583|dbj|BAB09196.1| unnamed protein product [Arabidopsis thaliana], gi|28416527|gb|AAO42794.1...
3.0E-32 [5..372] [326..679]
dma1 - mitotic spindle checkpoint protein Dma1
DMA1_SCHPO - Probable E3 ubiquitin-protein ligase dma1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=...
3.0E-30 [155..393] [28..258]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-28 [5..273] [34..284]
RNF12_MOUSE - E3 ubiquitin-protein ligase RLIM OS=Mus musculus GN=Rlim PE=1 SV=2
3.0E-27 [9..382] [214..598]

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Predicted Domain #1
Region A:
Residues: [1-118]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNTVPSSP PNQTPPAASG IATSHDHTKF NNPIRLPISI SLTINDTPNN NSNNNSVSNG  60
   61 LGILPSRTAT SLVVANNGSA NGNVGATAAA AATVETNTAP AVNTTKSIRH FIYPPNQV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [119-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQTEFSLDIH LPPNTSLPER IDQSTLKRRM DKHGLFSIRL TPFIDTSSTS VANQGLFFDP  60
   61 IIRTAGAGSQ IIIGRYTERV REAISKIPDQ YHPVVFKSKV ISRTHGCFKV DDQGNWFLKD 120
  121 VKSSSGTFLN HQRLSSASTT SKDYLLHDGD IIQLGMDFRG GTEEIYRCVK MKIELNKSWK 180
  181 LKANAFNKEA LSRIKNLQKL TTGLEQED

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [380-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LESESESEFE NEDEDEPDIE MDIDMEINNN LGVRLVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.49668552859347 bayes_pls_golite062009
motor activity 3.25814691068414 bayes_pls_golite062009
binding 2.69791297400248 bayes_pls_golite062009
tubulin binding 2.51210014078446 bayes_pls_golite062009
actin binding 2.38676888633305 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.20438586677555 bayes_pls_golite062009
microtubule binding 2.17136406283012 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
small conjugating protein ligase activity 1.97264874084155 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
structural constituent of muscle 1.30669499755555 bayes_pls_golite062009
acid-amino acid ligase activity 1.26357595913158 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
microfilament motor activity 1.0725773039399 bayes_pls_golite062009
signal transducer activity 0.999269271132931 bayes_pls_golite062009
molecular transducer activity 0.999269271132931 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
actin filament binding 0.836375875773328 bayes_pls_golite062009
structural molecule activity 0.800850121197479 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.748479359639348 bayes_pls_golite062009
kinase activity 0.662911740280035 bayes_pls_golite062009
N-terminal myristoylation domain binding 0.63045154489014 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.493362981045534 bayes_pls_golite062009
G-protein beta/gamma-subunit binding 0.487272307313601 bayes_pls_golite062009
enzyme regulator activity 0.456661966897198 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.452350351194157 bayes_pls_golite062009
protein phosphorylated amino acid binding 0.43808715710519 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.382055332967642 bayes_pls_golite062009
enzyme activator activity 0.369738999181035 bayes_pls_golite062009
actin-dependent ATPase activity 0.3688716707761 bayes_pls_golite062009
pyrophosphatase activity 0.321819287555157 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.30564870400158 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.305174269756747 bayes_pls_golite062009
kinase regulator activity 0.262406945568467 bayes_pls_golite062009
transferase activity 0.169970258787201 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009
myosin binding 0.125186564742711 bayes_pls_golite062009
structural constituent of cytoskeleton 0.116648335890738 bayes_pls_golite062009
protein kinase activity 0.0865488336042732 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [327-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSICLNKIKP CQAIFISPCA HSWHFHCVRR LVIMNYPQFM CPNCRTNCDL ETT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle