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Protein Overview: STE20

General Information:
Name(s) found: STE20 / YHL007C [SGD]
Description(s) found:
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  • gi|6321780|ref|NP_011856.1| Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PA [NCBI NR]
  • gi|508679|gb|AAB69747.1| Ste20p: Protein kinase; component of the G-protein-coupled pheromone response pathway [Saccharomyces cerevisiae] [NCBI NR]
  • gi|417818|sp|Q03497.1|STE20_YEAST RecName: Full=Serine/threonine-protein kinase STE20 [NCBI NR]
  • pir||S28394 probable serine/threonine-specific protein kinase (EC 2.7.1.-) STE20 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|172747|gb|AAA35111.1| protein kinase [Saccharomyces cerevisiae] [NCBI NR]
  • Serine/threonine-protein kinase STE20 OS=Saccharomyces cerevisiae GN=STE20 PE=1 SV=1 [Swiss-Prot]
  • (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.1.37) [Swiss-Prot]
  • STE20 Ser/thr protein kinase of the pheromone pathway [mips]
  • Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p [SGD]
  • STE20, Chr VIII from 95113-97932, reverse complement [yeast_orfs2]
  • Chr VIII from 95113-97932, reverse complement [yeastorf3.fasta]
  • Chr VIII from 97932-95113, reverse complement [yeastorf5.fasta]
  • (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.1.-) [4932.FASTACCERV.txt]
  • STE20 SGDID:S0000999, Chr VIII from 97932-95113, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases [Saccharomyces cer [nrdb_11152004_Chlamydomonas]
  • STE20 SGDID:S000000999, Chr VIII from 97933-95114, reverse complement, Verified ORF, "Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • STE20 SGDID:S000000999, Chr VIII from 97933-95114, reverse complement, Verified ORF, "Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response, pseudohyphal/invasive growth, and vacuole inheritanc [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta]
  • protein kinase [nr-271106-contam.fasta]
  • Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases; Ste20p [Saccharom [nr-271106-contam.fasta]
  • Serine/threonine-protein kinase STE20 [nr-271106-contam.fasta]
  • Ste20p: Protein kinase; component of the G-protein-coupled pheromone response pathway [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • STE20 SGDID:S000000999, Chr VIII from 97933-95114, reverse complement, Verified ORF, "Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases" [yeast-bovrabprots.fasta]
  • STE20 SGDID:S000000999, Chr VIII from 97933-95114, reverse complement, Verified ORF, "Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response, pseudohyphal/invasive growth, and vacuole inheritance; GBB motif (found in noncatalytic domains of PAKs) binds Ste4p" [scerevisihumanrev.fasta]
  • [chemostatdb.fasta]
  • Serine/threonine-protein kinase STE20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE20 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • STE20 SGDID:S000000999, Chr VIII from 97937-95118, Genome Release 64-1-1, reverse complement, Verified ORF, "Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p" [yeast-030211-contam.fasta]
  • STE20 SGDID:S000000999, Chr VIII from 97937-95118, Genome Release 64-2-1, reverse complement, Verified ORF, "Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family" [20141208_orf_trans.fasta]
  • YHL007C SGDID:S000000999, Chr VIII from 97937-95118, Genome Release 64-1-1, reverse complement, Verified ORF, "Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 939 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    mating projection tip [IDALink to PubMed article]
    Biological Process: cellular bud site selection [IMPLink to PubMed article]
    regulation of exit from mitosis [IMPLink to PubMed article]
    pseudohyphal growth [TASLink to PubMed article]
    invasive growth in response to glucose limitation [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    pheromone-dependent signal transduction involved in conjugation with cellular fusion [TASLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNDPSAVSE LPDKDSLDNG ISNDNERAMG GNGDGGDGLR LPRTTGTLNV NALQKGTNAA  60
   61 HEAGGYKSMD PAKNAETTND DDNNVVSLDD PIQFTRVSSS SVISGMSSSM SPHSNIDETK 120
  121 SLEAVTPNIN TSNITPDHSA DNTFSTINAS ESDHQFNDTL LSKLSLTDST ETIENNATVK 180
  181 HQQPVASSTV NSNKSSTDIR RATPVSTPVI SKPSMTTTPR QINSASHSLS NPKHKQHKPK 240
  241 VKPSKPEAKS KPVSVKKSFP SKNPLKNSSP PKKQTEKSYY SSSSKKRKSG SNSGTLRMKD 300
  301 VFTSFVQNIK RNSQDDKRAS SSSNNSSSSS ITTALRISTP YNAKHIHHVG VDSKTGEYTG 360
  361 LPEEWEKLLT SSGISKREQQ QNMQAVMDIV KFYQDVTETN GEDKMFKTFN TTTGLPGSPQ 420
  421 VSTPPANSFN KFPPSTSDSH NYGSRTGTPM SNHVMSPTLN TDSSSANGKF IPSRPAPKPP 480
  481 SSASASAPII KSPVMNSAAN VSPLKQTHAP TTPNRTSPNR SSISRNATLK KEEQPLPPIP 540
  541 PTKSKTSPII STAHTPQQVA QSPKAPAQET VTTPTSKPAQ ARSLSKELNE KKREERERRK 600
  601 KQLYAKLNEI CSDGDPSTKY ANLVKIGQGA SGGVYTAYEI GTNVSVAIKQ MNLEKQPKKE 660
  661 LIINEILVMK GSKHPNIVNF IDSYVLKGDL WVIMEYMEGG SLTDVVTHCI LTEGQIGAVC 720
  721 RETLSGLEFL HSKGVLHRDI KSDNILLSME GDIKLTDFGF CAQINELNLK RTTMVGTPYW 780
  781 MAPEVVSRKE YGPKVDIWSL GIMIIEMIEG EPPYLNETPL RALYLIATNG TPKLKEPENL 840
  841 SSSLKKFLDW CLCVEPEDRA SATELLHDEY ITEIAEANSS LAPLVKLARL KKVAENMDAD 900
  901 EDNDDDNDNE HINKTNNCDD NNDSKETVNL DVTEDDKQK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DRS1 ERB1 HAA1 HRQ1 MKT1 STE20 UBP1
    View Details Ho Y, et al. (2002) CAR2 DMA2 DUN1 FAR1 GPD1 GPD2 LSP1 MDM30 PDC6 PIL1 RAD1 SAW1 SEC6 SEN1 STE20 UBI4 YHR033W
    View Details Qiu et al. (2008) BEM1 CBK1 FUS3 STE20 STE7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC42 STE20 2 Drees BL, et al. (2001)
    View Screen BUD7 STE20 2 Unpublished Fields Lab Data
    View Screen SEC17 STE20 1 Unpublished Fields Lab Data
    View Screen YDR131C STE20 1 Unpublished Fields Lab Data
    View Screen UBC6 STE20 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data STE20 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] deduced N/A No confident structure predictions are available.
    2 View Details [70..294] ORFEUS 11.93 Fibrinogen
    3 View Details [295..411] PSI-BLAST 139.85005 pak1 autoregulatory domain
    4 View Details [412..598] ORFEUS 14.31 Sec24
    5 View Details [599..696] PSI-BLAST 1238.0 pak1
    6 View Details [697..939] PSI-BLAST 1238.0 pak1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle