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View Structure Prediction Details

Protein: STE20
Organism: Saccharomyces cerevisiae
Length: 939 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STE20.

Description E-value Query
Range
Subject
Range
STE20 - Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in phe...
STE20_YEAST - Serine/threonine-protein kinase STE20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ST...
0.0 [1..939] [1..939]
gi|6331022 - gi|6331022|dbj|BAA86578.1| KIAA1264 protein [Homo sapiens]
0.0 [119..889] [4..751]
gi|134088321, gi... - gi|50258679|gb|EAL21364.1| hypothetical protein CNBD0600 [Cryptococcus neoformans var. neoformans B-...
gi|58265924, gi|... - gi|58265924|ref|XP_570118.1| STE20 [Cryptococcus neoformans var. neoformans JEC21], gi|57226351|gb|A...
gi|12060949 - gi|12060949|gb|AAG48305.1|AF315635_1 STE20 [Cryptococcus neoformans var. neoformans]
0.0 [199..892] [27..641]
gi|12744913 - gi|12744913|gb|AAK06844.1|AF332388_1 protein kinase STE20p [Pneumocystis carinii]
0.0 [220..873] [24..686]
gi|12060951 - gi|12060951|gb|AAG48306.1|AF315636_1 STE20 [Cryptococcus neoformans var. grubii]
0.0 [206..892] [34..638]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [245..898] [10..622]

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Predicted Domain #1
Region A:
Residues: [1-69]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNDPSAVSE LPDKDSLDNG ISNDNERAMG GNGDGGDGLR LPRTTGTLNV NALQKGTNAA  60
   61 HEAGGYKSM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [70-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPAKNAETTN DDDNNVVSLD DPIQFTRVSS SSVISGMSSS MSPHSNIDET KSLEAVTPNI  60
   61 NTSNITPDHS ADNTFSTINA SESDHQFNDT LLSKLSLTDS TETIENNATV KHQQPVASST 120
  121 VNSNKSSTDI RRATPVSTPV ISKPSMTTTP RQINSASHSL SNPKHKQHKP KVKPSKPEAK 180
  181 SKPVSVKKSF PSKNPLKNSS PPKKQTEKSY YSSSSKKRKS GSNSG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.93
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [295-411]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLRMKDVFTS FVQNIKRNSQ DDKRASSSSN NSSSSSITTA LRISTPYNAK HIHHVGVDSK  60
   61 TGEYTGLPEE WEKLLTSSGI SKREQQQNMQ AVMDIVKFYQ DVTETNGEDK MFKTFNT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 139.85005
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [412-598]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTGLPGSPQV STPPANSFNK FPPSTSDSHN YGSRTGTPMS NHVMSPTLNT DSSSANGKFI  60
   61 PSRPAPKPPS SASASAPIIK SPVMNSAANV SPLKQTHAPT TPNRTSPNRS SISRNATLKK 120
  121 EEQPLPPIPP TKSKTSPIIS TAHTPQQVAQ SPKAPAQETV TTPTSKPAQA RSLSKELNEK 180
  181 KREERER

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.31
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [599-696]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKKQLYAKLN EICSDGDPST KYANLVKIGQ GASGGVYTAY EIGTNVSVAI KQMNLEKQPK  60
   61 KELIINEILV MKGSKHPNIV NFIDSYVLKG DLWVIMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1238.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [697-939]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGGSLTDVV THCILTEGQI GAVCRETLSG LEFLHSKGVL HRDIKSDNIL LSMEGDIKLT  60
   61 DFGFCAQINE LNLKRTTMVG TPYWMAPEVV SRKEYGPKVD IWSLGIMIIE MIEGEPPYLN 120
  121 ETPLRALYLI ATNGTPKLKE PENLSSSLKK FLDWCLCVEP EDRASATELL HDEYITEIAE 180
  181 ANSSLAPLVK LARLKKVAEN MDADEDNDDD NDNEHINKTN NCDDNNDSKE TVNLDVTEDD 240
  241 KQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1238.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle