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Protein Overview: DDI1

General Information:
Name(s) found: DDI1 / YER143W [SGD]
Description(s) found:
Found 28 descriptions.
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  • DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 428 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: vesicle-mediated transport [IGILink to PubMed article][IMPLink to PubMed article]
    ubiquitin-dependent protein catabolic process [IMPLink to PubMed article]
    Molecular Function: SNARE binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLTISNELT GEIYGPIEVS EDMALTDLIA LLQADCGFDK TKHDLYYNMD ILDSNRTQSL  60
   61 KELGLKTDDL LLIRGKISNS IQTDAATLSD EAFIEQFRQE LLNNQMLRSQ LILQIPGLND 120
  121 LVNDPLLFRE RLGPLILQRR YGGYNTAMNP FGIPQDEYTR LMANPDDPDN KKRIAELLDQ 180
  181 QAIDEQLRNA IEYTPEMFTQ VPMLYINIEI NNYPVKAFVD TGAQTTIMST RLAKKTGLSR 240
  241 MIDKRFIGEA RGVGTGKIIG RIHQAQVKIE TQYIPCSFTV LDTDIDVLIG LDMLKRHLAC 300
  301 VDLKENVLRI AEVETSFLSE AEIPKSFQEG LPAPTSVTTS SDKPLTPTKT SSTLPPQPGA 360
  361 VPALAPRTGM GPTPTGRSTA GATTATGRTF PEQTIKQLMD LGFPRDAVVK ALKQTNGNAE 420
  421 FAASLLFQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSL4 DDI1 DIS3 ENT3 LRP1 MPP6 MTR3 OSM1 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 SKI6 SKI7 YBL055C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen BUB2 DDI1 2 Uetz P, et al. (2000)
    View Screen ATG12 DDI1 1 Unpublished Fields Lab Data
    View Screen CDC48 DDI1 1 Unpublished Fields Lab Data
    View Screen RPT3 DDI1 1 Unpublished Fields Lab Data
    View Screen YPT1 DDI1 1 Unpublished Fields Lab Data
    View Screen YJR141W DDI1 1 Unpublished Fields Lab Data
    View Screen APC5 DDI1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DDI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] PSI-BLAST 20.39794 Ubiquitin
    2 View Details [83..151] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [152..304] PSI-BLAST 19.69897 Human immunodeficiency virus type 1 protease
    4 View Details [305..387] PSI-BLAST 7.39794 No description for 1rvnA_ was found.
    5 View Details [388..428] PSI-BLAST 4.522879 DNA repair protein Hhr23a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.55392638191535 bayes_pls_golite062009
  • protein binding
    		•  1.54942742559883 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.28693841442604 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.670372579002346 bayes_pls_golite062009
  • hydrolase activity
    		•  0.385840034768257 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle