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Protein Overview: CYM1

General Information:
Name(s) found: CYM1 / YDR430C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 989 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial intermembrane space [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: proteolysis [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: metalloendopeptidase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRFQRFASS YAQAQAVRKY PVGGIFHGYE VRRILPVPEL RLTAVDLVHS QTGAEHLHID  60
   61 RDDKNNVFSI AFKTNPPDST GVPHILEHTT LCGSVKYPVR DPFFKMLNKS LANFMNAMTG 120
  121 PDYTFFPFST TNPQDFANLR GVYLDSTLNP LLKQEDFDQE GWRLEHKNIT DPESNIVFKG 180
  181 VVYNEMKGQI SNANYYFWSK FQQSIYPSLN NSGGDPMKIT DLRYGDLLDF HHKNYHPSNA 240
  241 KTFTYGNLPL VDTLKQLNEQ FSGYGKRARK DKLLMPIDLK KDIDVKLLGQ IDTMLPPEKQ 300
  301 TKASMTWICG APQDTYDTFL LKVLGNLLMD GHSSVMYQKL IESGIGLEFS VNSGVEPTTA 360
  361 VNLLTVGIQG VSDIEIFKDT VNNIFQNLLE TEHPFDRKRI DAIIEQLELS KKDQKADFGL 420
  421 QLLYSILPGW TNKIDPFESL LFEDVLQRFR GDLETKGDTL FQDLIRKYIV HKPCFTFSIQ 480
  481 GSEEFSKSLD DEEQTRLREK ITALDEQDKK NIFKRGILLQ EKQNEKEDLS CLPTLQIKDI 540
  541 PRAGDKYSIE QKNNTMSRIT DTNGITYVRG KRLLNDIIPF ELFPYLPLFA ESLTNLGTTT 600
  601 ESFSEIEDQI KLHTGGISTH VEVTSDPNTT EPRLIFGFDG WSLNSKTDHI FEFWSKILLE 660
  661 TDFHKNSDKL KVLIRLLASS NTSSVADAGH AFARGYSAAH YRSSGAINET LNGIEQLQFI 720
  721 NRLHSLLDNE ETFQREVVDK LTELQKYIVD TNNMNFFITS DSDVQAKTVE SQISKFMERL 780
  781 PHGSCLPNGP KTSDYPLIGS KCKHTLIKFP FQVHYTSQAL LGVPYTHKDG SALQVMSNML 840
  841 TFKHLHREVR EKGGAYGGGA SYSALAGIFS FYSYRDPQPL KSLETFKNSG RYILNDAKWG 900
  901 VTDLDEAKLT IFQQVDAPKS PKGEGVTYFM SGVTDDMKQA RREQLLDVSL LDVHRVAEKY 960
  961 LLNKEGVSTV IGPGIEGKTV SPNWEVKEL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) CYM1 MSS51
    View Details Gavin AC, et al. (2002) APM1 CYM1 DOA4 DUR1,2 HSP42 LAT1 LPD1 PDA1 PDB1 PDX1 PRP46 RPN11 TCM62
    View Details Qiu et al. (2008) CYM1 PRD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC23 CYM1 1 Unpublished Fields Lab Data
    View Screen NUC1 CYM1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CYM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190]
    [209..277]
    [413..447]    		 PSI-BLAST 91.69897 Cytochrome bc1 core subunit 1
    2 View Details [191..208]
    [278..412]
    [448..532]    		 PSI-BLAST 91.69897 Cytochrome bc1 core subunit 1
    3 View Details [533..698]
    [723..792]    		 PSI-BLAST 19.0 Cytochrome bc1 core subunit 2
    4 View Details [699..722]
    [793..916]    		 PSI-BLAST 19.0 Cytochrome bc1 core subunit 2
    5 View Details [917..989] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • metalloendopeptidase activity
    		•  3.72038852665442 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.60100837479757 bayes_pls_golite062009
  • peptidase activity
    		•  3.59435865021473 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.51928093329287 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.00607833553933 bayes_pls_golite062009
  • hydrolase activity
    		•  2.42559068821325 bayes_pls_golite062009
  • catalytic activity
    		•  1.30647052031202 bayes_pls_golite062009
  • binding
    		•  0.820758410659358 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle