Protein Overview: RNH202

General Information:
Name(s) found:	RNH202 / YDR279W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74583518\|sp\|Q05635.1\|RNH2B_YEAST RecName: Full=Ribonuclease H2 subunit B; Short=RNase H2 subunit B; Short=Rnh2B; AltName: Full=Ribonuclease HI subunit B; AltName: Full=RNase H(202) [NCBI NR] gi\|6320485\|ref\|NP_010565.1\| Ribonuclease H2 subunit, required for RNase H2 activity; Rnh202p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S70135 hypothetical protein YDR279w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1230648\|gb\|AAB64447.1\| Ydr279wp [Saccharomyces cerevisiae] [NCBI NR] Ribonuclease H2 subunit B OS=Saccharomyces cerevisiae GN=RNH202 PE=1 SV=1 [Swiss-Prot] RNH202 Ribonuclease H2 subunit, required for RNase H2 activity [mips] Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome [SGD] YDR279W, Chr IV from 1019359-1020411 [yeast_orfs2] Chr IV from 1019359-1020411 [yeastorf3.fasta] >Q05635 (Q05635) Chromosome IV COSMID 9954 [4932.FASTACCERV.txt] RNH202 SGDID:S0002687, Chr IV from 1019360-1020412, Verified ORF [yeastflysequest.fasta] RNH202 SGDID:S0002687, Chr IV from 1019362-1020414, Verified ORF [10112005cervSGD.fasta] Ribonuclease H2 subunit, required for RNase H2 activity [Saccharomyces cerevisiae]gi\|2131412\|pir\|\|S70135 hypothetical protein YDR279w - yeast (Saccharomyces cerevisiae)gi\|1230648\|gb\|AAB64447.1\| Ydr279wp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] (Q05635) Ydr279wp [cerv4932.FASTAC] RNH202 SGDID:S000002687, Chr IV from 1019362-1020414, Verified ORF, "Ribonuclease H2 subunit, required for RNase H2 activity" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] RNH202 SGDID:S000002687, Chr IV from 1019364-1020416, Verified ORF, "Ribonuclease H2 subunit, required for RNase H2 activity" [yeast-contam.fasta] RNH202 SGDID:S000002687, Chr IV from 1019365-1020417, Verified ORF, "Ribonuclease H2 subunit, required for RNase H2 activity" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] RNH202 SGDID:S000002687, Chr IV from 1019365-1020417, Verified ORF, "Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome" [yeast-200209-contam.fasta] Ribonuclease H2 subunit B (RNase H2 subunit B) (Ribonuclease HI subunit B) (Rnh2B) (RNase H(202)) [nr-271106-contam.fasta] Ribonuclease H2 subunit, required for RNase H2 activity; Rnh202p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ydr279wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Ribonuclease H2 subunit B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RNH202 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] RNH202 SGDID:S000002687, Chr IV from 1019368-1020420, Genome Release 64-1-1, Verified ORF, "Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome" [yeast-030211-contam.fasta] RNH202 SGDID:S000002687, Chr IV from 1019368-1020420, Genome Release 64-2-1, Verified ORF, "Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome" [20141208_orf_trans.fasta] YDR279W SGDID:S000002687, Chr IV from 1019368-1020420, Genome Release 64-1-1, Verified ORF, "Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	350 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] ribonuclease H2 complex [IDA]
Biological Process:	DNA replication [IPI]
Molecular Function:	ribonuclease H activity [IDA][IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVSNIGGEE RLIILPDDYE TSKTINTFTL PPPSNITSKP RIELFENING KLYEIRSFQF  60
   61 GKGPSYSHEE DLANDKYHYT KENHPIKSTF IVNTSDPTDG YVFNSSKIHF CSLYDIAFSL 120
  121 IGFYYRNSVS ADEQDYSNSS DTGENQKSNS KTNEKFLTVR DYHDFLTDNH DKNWENISLS 180
  181 RLKSGLAKVS ETIEEAGDVY YKITSAMITQ FLLGKVSKIV ENFPPSIPTL KNAPTEIKQC 240
  241 YKVVMATNLL VSLIPRAAYH NLLTFSPTMD SGCLNPDIKA SFIELENYET TNELQNAERE 300
  301 LLMKSAMNVG LNSNGRVSLP VKKVTKKIVQ NKKPKVAIGK GAIDGFFKRK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		RNH201 RNH202
View Details	Krogan NJ, et al. (2006)		RNH201 RNH202 RNH203
View Details	Ho Y, et al. (2002)		AAC3 ADO1 BUD32 CAR2 CPR6 CRM1 DIA4 GRX3 GRX4 HEF3 IDP2 IMD2 IMD4 INP52 KAE1 NPA3 PHO81 RNH202 RNQ1 RPN1 RPN5 RPN6 RPT1 SAP190 SEC18 SEC23 SGO1 TIF1, TIF2 TMA29 URA7 YHB1 YHR033W
View Details	Qiu et al. (2008)		RNH201 RNH202 RNH203

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CTF13	RNH202	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RNH202	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..350]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2