Protein Overview: CCC2

General Information:
Name(s) found:	CCC2 / YDR270W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|728935\|sp\|P38995.1\|ATU2_YEAST RecName: Full=Copper-transporting ATPase; AltName: Full=Cu(2+)-ATPase [NCBI NR] gi\|6320475\|ref\|NP_010556.1\| Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; Ccc2p [Saccharomyces cerevisiae] [NCBI NR] gi\|538515\|gb\|AAC37425.1\| Cu++-transporting P-type ATPase [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S55353 probable copper-transporting ATPase (EC 3.6.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1230642\|gb\|AAB64451.1\| Ccc2p: Probable Copper-transporting ATPase (Swiss Prot. accession number P38995). [Saccharomyces cerevisiae] [NCBI NR] Copper-transporting ATPase OS=Saccharomyces cerevisiae GN=CCC2 PE=1 SV=1 [Swiss-Prot] CCC2 P-type ATPase involved in export of Cu++ from the cytosol into intracellular, secretory compartments [mips] Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases [SGD] CCC2, Chr IV from 1005666-1008680 [yeast_orfs2] Chr IV from 1005666-1008680 [yeastorf3.fasta] (P38995) Probable copper-transporting ATPase (EC 3.6.3.4) (Cu(2+)-ATPase) [4932.FASTACCERV.txt] CCC2 SGDID:S0002678, Chr IV from 1005667-1008681, Verified ORF [yeastflysequest.fasta] CCC2 SGDID:S0002678, Chr IV from 1005669-1008683, Verified ORF [10112005cervSGD.fasta] Ccc2p [Saccharomyces cerevisiae]gi\|1362274\|pir\|\|S55353 probable copper-transporting ATPase (EC 3.6.1.-) - yeast (Saccharomyces cerevisiae)gi\|538515\|gb\|AAC37425.1\| Cu++-transporting P-type ATPasegi\|1230642\|gb\|AAB64451.1\| Ccc2p: Probable Copper-transpor [nrdb_11152004_Chlamydomonas] CCC2 SGDID:S000002678, Chr IV from 1005669-1008683, Verified ORF, "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseas [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CCC2 SGDID:S000002678, Chr IV from 1005671-1008685, Verified ORF, "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseas [yeast-contam.fasta] CCC2 SGDID:S000002678, Chr IV from 1005672-1008686, Verified ORF, "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseas [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; Ccc2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Copper-transporting ATPase (Cu(2+)-ATPase) [nr-271106-contam.fasta] Ccc2p: Probable Copper-transporting ATPase (Swiss Prot. accession number P38995). [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Cu++-transporting P-type ATPase [nr-271106-contam.fasta] CCC2 SGDID:S000002678, Chr IV from 1005672-1008686, Verified ORF, "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases" [yeast-bovrabprots.fasta] CCC2 SGDID:S000002678, Chr IV from 1005671-1008685, Verified ORF, "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases" [yeast-contam_custom.fasta] [chemostatdb.fasta] Copper-transporting ATPase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCC2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CCC2 SGDID:S000002678, Chr IV from 1005675-1008689, Genome Release 64-1-1, Verified ORF, "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases" [yeast-030211-contam.fasta] CCC2 SGDID:S000002678, Chr IV from 1005675-1008689, Genome Release 64-2-1, Verified ORF, "Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism" [20141208_orf_trans.fasta] YDR270W SGDID:S000002678, Chr IV from 1005675-1008689, Genome Release 64-1-1, Verified ORF, "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	1004 amino acids
Gene Ontology:
Cellular Component:	trans-Golgi network transport vesicle membrane [IDA]
Biological Process:	cellular iron ion homeostasis [IMP] intracellular copper ion transport [IMP]
Molecular Function:	cation-transporting ATPase activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREVILAVHG MTCSACTNTI NTQLRALKGV TKCDISLVTN ECQVTYDNEV TADSIKEIIE  60
   61 DCGFDCEILR DSEITAISTK EGLLSVQGMT CGSCVSTVTK QVEGIEGVES VVVSLVTEEC 120
  121 HVIYEPSKTT LETAREMIED CGFDSNIIMD GNGNADMTEK TVILKVTKAF EDESPLILSS 180
  181 VSERFQFLLD LGVKSIEISD DMHTLTIKYC CNELGIRDLL RHLERTGYKF TVFSNLDNTT 240
  241 QLRLLSKEDE IRFWKKNSIK STLLAIICML LYMIVPMMWP TIVQDRIFPY KETSFVRGLF 300
  301 YRDILGVILA SYIQFSVGFY FYKAAWASLK HGSGTMDTLV CVSTTCAYTF SVFSLVHNMF 360
  361 HPSSTGKLPR IVFDTSIMII SYISIGKYLE TLAKSQTSTA LSKLIQLTPS VCSIISDVER 420
  421 NETKEIPIEL LQVNDIVEIK PGMKIPADGI ITRGESEIDE SLMTGESILV PKKTGFPVIA 480
  481 GSVNGPGHFY FRTTTVGEET KLANIIKVMK EAQLSKAPIQ GYADYLASIF VPGILILAVL 540
  541 TFFIWCFILN ISANPPVAFT ANTKADNFFI CLQTATSVVI VACPCALGLA TPTAIMVGTG 600
  601 VGAQNGVLIK GGEVLEKFNS ITTFVFDKTG TLTTGFMVVK KFLKDSNWVG NVDEDEVLAC 660
  661 IKATESISDH PVSKAIIRYC DGLNCNKALN AVVLESEYVL GKGIVSKCQV NGNTYDICIG 720
  721 NEALILEDAL KKSGFINSNV DQGNTVSYVS VNGHVFGLFE INDEVKHDSY ATVQYLQRNG 780
  781 YETYMITGDN NSAAKRVARE VGISFENVYS DVSPTGKCDL VKKIQDKEGN NKVAVVGDGI 840
  841 NDAPALALSD LGIAISTGTE IAIEAADIVI LCGNDLNTNS LRGLANAIDI SLKTFKRIKL 900
  901 NLFWALCYNI FMIPIAMGVL IPWGITLPPM LAGLAMAFSS VSVVLSSLML KKWTPPDIES 960
  961 HGISDFKSKF SIGNFWSRLF STRAIAGEQD IESQAGLMSN EEVL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ARC1 ATG14 CAT8 CCC2 HEK2 IRC20 MCA1 MES1 MGA2 NCS2 NHA1 PET127 PHO89 PHO91 YKL050C YLR363W-A
View Details	Qiu et al. (2008)		CCC2 DNF3 ENB1 PMR1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	VAM3	Sample: HX14 - mixture in detergent (control).	Hao Xu, et al. (2010)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..75]	PSI-BLAST	350.68867	Copper transporter domain ccc2a
2	View Details	[76..163]	PSI-BLAST	56.0	Potential copper-translocating P-type ATPase
3	View Details	[164..282]	ORFEUS	11.46	Copper chaperone
4	View Details	[283..335]	deduced	N/A	No confident structure predictions are available.
5	View Details	[336..409] [554..1004]	PSI-BLAST	221.9897	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
6	View Details	[410..553]	PSI-BLAST	221.9897	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
copper chaperone activity	9.82063669832995	bayes_pls_golite062009
copper-dependent protein binding	9.4886676850819	bayes_pls_golite062009
metallochaperone activity	8.74818422646376	bayes_pls_golite062009
copper ion transmembrane transporter activity	8.43432598400875	bayes_pls_golite062009
copper-exporting ATPase activity	8.28760545731379	bayes_pls_golite062009
copper-transporting ATPase activity	8.16711362928142	bayes_pls_golite062009
superoxide dismutase copper chaperone activity	7.67724993505658	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	7.20908701283122	bayes_pls_golite062009
copper ion binding	5.41725082570189	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.4007166857771	bayes_pls_golite062009
cation transmembrane transporter activity	4.61622753861072	bayes_pls_golite062009
ion transmembrane transporter activity	4.52484959112186	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.12792340516867	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	4.10264569844449	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	3.70964017127302	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	3.27250923701445	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	2.98847682261773	bayes_pls_golite062009
metal ion binding	2.69806984896689	bayes_pls_golite062009
cation binding	2.69806984896689	bayes_pls_golite062009
ion binding	2.69078950610234	bayes_pls_golite062009
transition metal ion binding	2.52520930681159	bayes_pls_golite062009
transporter activity	2.43435890488191	bayes_pls_golite062009
transmembrane transporter activity	2.32163502360862	bayes_pls_golite062009
binding	2.31155280022787	bayes_pls_golite062009
substrate-specific transporter activity	2.28845421748925	bayes_pls_golite062009
primary active transmembrane transporter activity	1.62116507842838	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.61680623728503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.59572740343301	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	1.5925429451548	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	1.59219836319916	bayes_pls_golite062009
active transmembrane transporter activity	1.53883152283038	bayes_pls_golite062009
hydrolase activity	1.26149508477113	bayes_pls_golite062009
ATPase activity	1.12732384636594	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.1123150216263	bayes_pls_golite062009
pyrophosphatase activity	1.04872000948037	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.03270166246194	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.02977205960797	bayes_pls_golite062009
ATPase activity, coupled	1.02520458852568	bayes_pls_golite062009
protein binding	0.889287086236279	bayes_pls_golite062009
cation-transporting ATPase activity	0.75722873989123	bayes_pls_golite062009

Term	Confidence	Notes
copper chaperone activity	9.82063669832995	bayes_pls_golite062009
copper-dependent protein binding	9.4886676850819	bayes_pls_golite062009
metallochaperone activity	8.74818422646376	bayes_pls_golite062009
copper ion transmembrane transporter activity	8.43432598400875	bayes_pls_golite062009
copper-exporting ATPase activity	8.28760545731379	bayes_pls_golite062009
copper-transporting ATPase activity	8.16711362928142	bayes_pls_golite062009
superoxide dismutase copper chaperone activity	7.67724993505658	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	7.20908701283122	bayes_pls_golite062009
copper ion binding	5.41725082570189	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.4007166857771	bayes_pls_golite062009
cation transmembrane transporter activity	4.61622753861072	bayes_pls_golite062009
ion transmembrane transporter activity	4.52484959112186	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.12792340516867	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	4.10264569844449	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	3.70964017127302	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	3.27250923701445	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	2.98847682261773	bayes_pls_golite062009
metal ion binding	2.69806984896689	bayes_pls_golite062009
cation binding	2.69806984896689	bayes_pls_golite062009
ion binding	2.69078950610234	bayes_pls_golite062009
transition metal ion binding	2.52520930681159	bayes_pls_golite062009
transporter activity	2.43435890488191	bayes_pls_golite062009
transmembrane transporter activity	2.32163502360862	bayes_pls_golite062009
binding	2.31155280022787	bayes_pls_golite062009
substrate-specific transporter activity	2.28845421748925	bayes_pls_golite062009
primary active transmembrane transporter activity	1.62116507842838	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.61680623728503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.59572740343301	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	1.5925429451548	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	1.59219836319916	bayes_pls_golite062009
active transmembrane transporter activity	1.53883152283038	bayes_pls_golite062009
hydrolase activity	1.26149508477113	bayes_pls_golite062009
ATPase activity	1.12732384636594	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.1123150216263	bayes_pls_golite062009
pyrophosphatase activity	1.04872000948037	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.03270166246194	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.02977205960797	bayes_pls_golite062009
ATPase activity, coupled	1.02520458852568	bayes_pls_golite062009
protein binding	0.889287086236279	bayes_pls_golite062009
cation-transporting ATPase activity	0.75722873989123	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

	PROTEIN(S)	PUBLICATION
View Data	CCC2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Protein Overview: CCC2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: