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Protein Overview: LYS4

General Information:
Name(s) found: LYS4 / YDR234W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 693 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TAS]
    Biological Process: lysine biosynthetic process via aminoadipic acid [NASLink to PubMed article]
    Molecular Function: homoaconitate hydratase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRSTTFTRS FHSSRAWLKG QNLTEKIVQS YAVNLPEGKV VHSGDYVSIK PAHCMSHDNS  60
   61 WPVALKFMGL GATKIKNPSQ IVTTLDHDIQ NKSEKNLTKY KNIENFAKKH HIDHYPAGRG 120
  121 IGHQIMIEEG YAFPLNMTVA SDSHSNTYGG LGSLGTPIVR TDAAAIWATG QTWWQIPPVA 180
  181 QVELKGQLPQ GVSGKDIIVA LCGLFNNDQV LNHAIEFTGD SLNALPIDHR LTIANMTTEW 240
  241 GALSGLFPVD KTLIDWYKNR LQKLGTNNHP RINPKTIRAL EEKAKIPKAD KDAHYAKKLI 300
  301 IDLATLTHYV SGPNSVKVSN TVQDLSQQDI KINKAYLVSC TNSRLSDLQS AADVVCPTGD 360
  361 LNKVNKVAPG VEFYVAAASS EIEADARKSG AWEKLLKAGC IPLPSGCGPC IGLGAGLLEP 420
  421 GEVGISATNR NFKGRMGSKD ALAYLASPAV VAASAVLGKI SSPAEVLSTS EIPFSGVKTE 480
  481 IIENPVVEEE VNAQTEAPKQ SVEILEGFPR EFSGELVLCD ADNINTDGIY PGKYTYQDDV 540
  541 PKEKMAQVCM ENYDAEFRTK VHPGDIVVSG FNFGTGSSRE QAATALLAKG INLVVSGSFG 600
  601 NIFSRNSINN ALLTLEIPAL IKKLREKYQG APKELTRRTG WFLKWDVADA KVVVTEGSLD 660
  661 GPVILEQKVG ELGKNLQEII VKGGLEGWVK SQL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ANT1 LYS4
    View Details Krogan NJ, et al. (2006) HFM1 LYS4 NEW1 RBG1 SGD1 SOK1 SSZ1 TCB1 TGL5 TMA46 YEF3 YLR072W ZUO1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC13 LYS4 1 Unpublished Fields Lab Data
    View Screen PRP42 LYS4 1 Unpublished Fields Lab Data
    View Screen SXM1 LYS4 1 Unpublished Fields Lab Data
    View Screen LIA1 LYS4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LYS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..505]
    [527..538]    		 PSI-BLAST 1295.228787 Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
    2 View Details [506..526]
    [539..693]    		 PSI-BLAST 1295.228787 Aconitase A, C-terminal domain; Aconitase A, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3-isopropylmalate dehydratase activity
    		•  11.6597692115322 bayes_pls_golite062009
  • aconitate hydratase activity
    		•  5.86356477922338 bayes_pls_golite062009
  • catalytic activity
    		•  2.4040324437254 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  2.08349115784849 bayes_pls_golite062009
  • hydro-lyase activity
    		•  2.04845291489052 bayes_pls_golite062009
  • lyase activity
    		•  2.0080619912194 bayes_pls_golite062009
  • RNA binding
    		•  1.22007129202809 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.952569345633996 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.290042934134994 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  0.239736179000069 bayes_pls_golite062009
  • metal cluster binding
    		•  0.239736179000069 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle