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View Structure Prediction Details

Protein: LYS4
Organism: Saccharomyces cerevisiae
Length: 693 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYS4.

Description E-value Query
Range
Subject
Range
gi|7437043 - gi|7437043|pir||T10101 aconitate hydratase (EC 4.2.1.3) - cucurbit
gi|868003 - gi|868003|dbj|BAA06108.1| aconitase [Cucurbita cv. Kurokawa Amakuri]
ACOC_CUCMA - Aconitate hydratase, cytoplasmic OS=Cucurbita maxima PE=2 SV=1
0.0 [2..693] [31..895]
gi|3309243 - gi|3309243|gb|AAC26045.1| aconitase-iron regulated protein 1 [Citrus limon]
0.0 [2..693] [31..895]
gi|239121 - gi|239121|gb|AAA03251.1| chimeric iron-responsive element-binding protein, chimeric IRE-BP [Peptide ...
gi|239121|gb|AAA... - chimeric iron-responsive element-binding protein, chimeric IRE-BP [Peptide Recombinant, 889 aa]
0.0 [2..693] [27..887]
ACO1 - aconitase 1, soluble
0.0 [2..693] [27..887]
gi|11066033 - gi|11066033|gb|AAG28426.1|AF194945_1 cytosolic aconitase [Nicotiana tabacum]
0.0 [2..693] [31..895]
gi|18098515 - gi|18098515|emb|CAD20353.1| cytoplasmic aconitase [Mus musculus]
0.0 [2..693] [27..897]
ACO1_ARATH - Aconitate hydratase 1 OS=Arabidopsis thaliana GN=ACO1 PE=1 SV=2
0.0 [2..693] [31..895]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [2..693] [53..916]

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Predicted Domain #1
Region A:
Residues: [1-505]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRSTTFTRS FHSSRAWLKG QNLTEKIVQS YAVNLPEGKV VHSGDYVSIK PAHCMSHDNS  60
   61 WPVALKFMGL GATKIKNPSQ IVTTLDHDIQ NKSEKNLTKY KNIENFAKKH HIDHYPAGRG 120
  121 IGHQIMIEEG YAFPLNMTVA SDSHSNTYGG LGSLGTPIVR TDAAAIWATG QTWWQIPPVA 180
  181 QVELKGQLPQ GVSGKDIIVA LCGLFNNDQV LNHAIEFTGD SLNALPIDHR LTIANMTTEW 240
  241 GALSGLFPVD KTLIDWYKNR LQKLGTNNHP RINPKTIRAL EEKAKIPKAD KDAHYAKKLI 300
  301 IDLATLTHYV SGPNSVKVSN TVQDLSQQDI KINKAYLVSC TNSRLSDLQS AADVVCPTGD 360
  361 LNKVNKVAPG VEFYVAAASS EIEADARKSG AWEKLLKAGC IPLPSGCGPC IGLGAGLLEP 420
  421 GEVGISATNR NFKGRMGSKD ALAYLASPAV VAASAVLGKI SSPAEVLSTS EIPFSGVKTE 480
  481 IIENPVVEEE VNAQTEAPKQ SVEIL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [527-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGIYPGKYTY QD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1295.228787
Match: 5acn__
Description: Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3-isopropylmalate dehydratase activity 11.6597692115322 bayes_pls_golite062009
aconitate hydratase activity 5.86356477922338 bayes_pls_golite062009
catalytic activity 2.4040324437254 bayes_pls_golite062009
carbon-oxygen lyase activity 2.08349115784849 bayes_pls_golite062009
hydro-lyase activity 2.04845291489052 bayes_pls_golite062009
lyase activity 2.0080619912194 bayes_pls_golite062009
RNA binding 1.22007129202809 bayes_pls_golite062009
structural constituent of ribosome 0.952569345633996 bayes_pls_golite062009
nucleic acid binding 0.290042934134994 bayes_pls_golite062009
iron-sulfur cluster binding 0.239736179000069 bayes_pls_golite062009
metal cluster binding 0.239736179000069 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [506-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGFPREFSGE LVLCDADNIN T

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [539-693]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVPKEKMAQV CMENYDAEFR TKVHPGDIVV SGFNFGTGSS REQAATALLA KGINLVVSGS  60
   61 FGNIFSRNSI NNALLTLEIP ALIKKLREKY QGAPKELTRR TGWFLKWDVA DAKVVVTEGS 120
  121 LDGPVILEQK VGELGKNLQE IIVKGGLEGW VKSQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1295.228787
Match: 5acn__
Description: Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle