Protein Overview: AIR2

General Information:
Name(s) found:	AIR2 / YDL175C [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	344 amino acids
Gene Ontology:
Cellular Component:	nucleus [IPI] TRAMP complex [IDA ][IPI ]
Biological Process:	mRNA export from nucleus [IMP] rRNA catabolic process [IGI] snRNA catabolic process [IGI] snoRNA catabolic process [IGI] tRNA catabolic process [IDA ] ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process [IDA][IGI]
Molecular Function:	polynucleotide adenylyltransferase activity [IDA ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKNTAPFVV DTAPTTPPDK LVAPSIEEVN SNPNELRALR GQGRYFGVSD DDKDAIKEAA  60
   61 PKCNNCSQRG HLKKDCPHII CSYCGATDDH YSRHCPKAIQ CSKCDEVGHY RSQCPHKWKK 120
  121 VQCTLCKSKK HSKERCPSIW RAYILVDDNE KAKPKVLPFH TIYCYNCGGK GHFGDDCKEK 180
  181 RSSRVPNEDG SAFTGSNLSV ELKQEYYRHM NRNSDENEDY QFSESIYDED PLPRPSHKRH 240
  241 SQNDHSHSGR NKRRASNFHP PPYQKSNVIQ PTIRGETLSL NNNISKNSRY QNTKVNVSSI 300
  301 SENMYGSRYN PSTYVDNNSI SNSSNYRNYN SYQPYRSGTL GKRR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		AIR2 MTR4 NAB3 PAP2 PRP43 SEN1
View Details	Krogan NJ, et al. (2006)		AIR1 AIR2 MTR4 PAP2 PSO2 RPL18A, RPL18B STE4 TRF5
View Details	Gavin AC, et al. (2002)		AIR2 BRR1 BUR2 CBC2 HTA1 KAP95 LUC7 MSH4 MUD1 NAB3 NAB6 NAM8 NPL3 NRD1 NUP60 PRP39 PRP40 PRP42 RSE1 SCP160 SEN1 SGV1 SMD1 SMD2 SMD3 SNP1 SNU56 SNU71 SRO9 SRP1 STO1 THO2 TIF4631 TIF4632 YRA2
View Details	Ho Y, et al. (2002)		ADH2 AIR1 AIR2 DED1 IMD1 IMD3 IMD4 MRPS35 MTR4 NAP1 NOP53 NOP56 NPL3 PAP2 PSE1 QCR2 SES1 SRP1
View Details	Qiu et al. (2008)		AIR1 AIR2 MTR4 PAP2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CAB4	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NOG1	AIR2	2	Unpublished Fields Lab Data
View Screen	MDM30	AIR2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	AIR2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..66]	PSI-BLAST	28.09691	HIV-1 CAPSID PROTEIN C-TERMINAL FRAGMENT PLUS GAG P2 DOMAIN
2	View Details	[67..120]	PSI-BLAST	18.221849	NUCLEOCAPSID ZINC FINGERS DETECTED IN RETROVIRUSES: EXAFS STUDIES ON INTACT VIRUSES AND THE SOLUTION-STATE STRUCTURE OF THE NUCLEOCAPSID PROTEIN FROM HIV-1
3	View Details	[121..172]	deduced	N/A	No confident structure predictions are available.
4	View Details	[173..278]	MSA	179.248997	View MSA. No confident structure predictions are available.
5	View Details	[279..344]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2