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Protein Overview: ENT1

General Information:
Name(s) found: ENT1 / YDL161W [SGD]
Description(s) found:
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  • gi|6320039|ref|NP_010120.1| Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; Ent1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|62900137|sp|Q12518.1|ENT1_YEAST RecName: Full=Epsin-1 [NCBI NR]
  • pir||S61052 hypothetical protein YDL161w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1431257|emb|CAA98736.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1061278|emb|CAA91585.1| putative protein [Saccharomyces cerevisiae] [NCBI NR]
  • Epsin-1 OS=Saccharomyces cerevisiae GN=ENT1 PE=1 SV=1 [Swiss-Prot]
  • ENT1 Clathrin binding protein, required for endocytosis [mips]
  • Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus [SGD]
  • ENT1, Chr IV from 167715-169079 [yeast_orfs2]
  • Chr IV from 167715-169079 [yeastorf3.fasta]
  • >Q12518 (Q12518) ORF YDL161W [4932.FASTACCERV.txt]
  • ENT1 SGDID:S0002320, Chr IV from 167715-169079, Verified ORF [yeastflysequest.fasta]
  • Ent1p [Saccharomyces cerevisiae]gi|1431257|emb|CAA98736.1| unnamed protein product [Saccharomyces cerevisiae]gi|1061278|emb|CAA91585.1| putative protein [Saccharomyces cerevisiae]gi|2131350|pir||S61052 hypothetical protein YDL161w - yeast (Saccharomyce [nrdb_11152004_Chlamydomonas]
  • (Q12518) ORF YDL161w (Hypothetical protein) [cerv4932.FASTAC]
  • ENT1 SGDID:S000002320, Chr IV from 167715-169079, Verified ORF, "Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • putative protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; Ent1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Epsin-1 [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Epsin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENT1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ENT1 SGDID:S000002320, Chr IV from 167714-169078, Genome Release 64-1-1, Verified ORF, "Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus" [yeast-030211-contam.fasta]
  • ENT1 SGDID:S000002320, Chr IV from 167714-169078, Genome Release 64-2-1, Verified ORF, "Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog, ENT2, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDL161W SGDID:S000002320, Chr IV from 167714-169078, Genome Release 64-1-1, Verified ORF, "Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_655|g.82 ORF ID=asmbl_655|g.82 ID=asmbl_655|m.82 type:complete len:455 (+) ID=asmbl_655:279-1643(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 454 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IPILink to PubMed article]
    Biological Process: actin filament organization [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    actin cortical patch assembly [IMPLink to PubMed article]
    Molecular Function: clathrin binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKQFVRSAK NLVKGYSSTQ VLVRNATSND NHQVSKDSLI ELAEKSYDSA DFFEIMDMLD  60
   61 KRLNDKGKYW RHIAKALTVI DYLIRFGSEN CVLWCRENLY IIKTLKEFRH EDDEGIDQGQ 120
  121 IVRVKAKELT ALLSDDERLN EERNMNIKGR NRKGRRRRGT GRSDENDDDL QRAISASRLT 180
  181 AEEDERRRKQ DEDYETALQL SKEEEELKRL QDLQRMQQQQ GQQQLQQPMY YDIFGNPITP 240
  241 EEYAQFQLQQ QQQQQQQQLQ QQPMYYDVFG NPITPEELAQ FQQQQQLQEQ QYLASMQQQQ 300
  301 QAMSNNPFAK SEQSSSSPKR NQLVAASSPQ QLQQQKQQEP LIQNRTGNQS MTDKYSKLNE 360
  361 LLATGTGIDT FGNVGEARIP AQHTKTGTFI NSQGTGYRQV SDDPNHNPFL NSQYTGLPST 420
  421 SVVPTQTGYG FGNQSQQQSQ NNGSNNRGYT LIDL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ABP1 AIP1 ARC15 ARK1 ARP2 BSP1 CAP1 COF1 CRN1 EDE1 END3 ENT1 ENT2 ENT3 ENT4 LAS17 PAN1 PRK1 RVS167 SAC6 SCP1 SLA1 SLA2 TPM1 TWF1 YAP1801 YAP1802

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ENT1 Huh WK, et al. (2003)
    View Data ENT1 and SAC6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 359.522879 Epsin 1
    2 View Details [156..454] MSA 36.242997 View MSA. No confident structure predictions are available.
    3 View Details [280..454] MSA 10.216997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.0641537286615 bayes_pls_golite062009
  • clathrin binding
    		•  2.70535896247543 bayes_pls_golite062009
  • protein binding
    		•  1.66643874221425 bayes_pls_golite062009
  • small conjugating protein binding
    		•  1.21080611070618 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.20269437433936 bayes_pls_golite062009
  • ubiquitin binding
    		•  1.13665923059109 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.87586037360588 bayes_pls_golite062009
  • phospholipid binding
    		•  0.84481265656013 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.825759910120848 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.811305015005335 bayes_pls_golite062009
  • DNA binding
    		•  0.653740976783835 bayes_pls_golite062009
  • lipid binding
    		•  0.176990783274449 bayes_pls_golite062009
  • GTPase binding
    		•  0.0887270623721197 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0408283656118 bayes_pls_golite062009
  • small GTPase binding
    		•  0.0268749201897704 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle