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View Structure Prediction Details

Protein: ENT1
Organism: Saccharomyces cerevisiae
Length: 454 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENT1.

Description E-value Query
Range
Subject
Range
gi|207347089 - gi|207347089|gb|EDZ73390.1| YDL161Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190405161 - gi|190405161|gb|EDV08428.1| epsin-1 [Saccharomyces cerevisiae RM11-1a]
ENT1_YEAST - Epsin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENT1 PE=1 SV=1
ENT1 - Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with ...
4.0E-84 [1..454] [1..454]
gi|3894395 - gi|3894395|gb|AAC78608.1| epsin 2a [Homo sapiens]
2.0E-78 [7..426] [8..454]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-73 [7..366] [139..496]
SPCC794.11c - ENTH domain protein Ent3
YCTB_SCHPO - ENTH domain-containing protein C794.11c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SP...
4.0E-73 [3..449] [17..433]
gi|8569264 - gi|8569264|pdb|1EYH|A Chain A, Crystal Structure Of The Epsin N-Terminal Homology (Enth) Domain At 1...
9.0E-69 [14..157] [1..144]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKQFVRSAK NLVKGYSSTQ VLVRNATSND NHQVSKDSLI ELAEKSYDSA DFFEIMDMLD  60
   61 KRLNDKGKYW RHIAKALTVI DYLIRFGSEN CVLWCRENLY IIKTLKEFRH EDDEGIDQGQ 120
  121 IVRVKAKELT ALLSDDERLN EERNMNIKGR NRKGR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 359.522879
Match: 1inzA_
Description: Epsin 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.0641537286615 bayes_pls_golite062009
clathrin binding 2.70535896247543 bayes_pls_golite062009
protein binding 1.66643874221425 bayes_pls_golite062009
small conjugating protein binding 1.21080611070618 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.20269437433936 bayes_pls_golite062009
ubiquitin binding 1.13665923059109 bayes_pls_golite062009
phosphoinositide binding 0.87586037360588 bayes_pls_golite062009
phospholipid binding 0.84481265656013 bayes_pls_golite062009
nucleic acid binding 0.825759910120848 bayes_pls_golite062009
transcription regulator activity 0.811305015005335 bayes_pls_golite062009
DNA binding 0.653740976783835 bayes_pls_golite062009
lipid binding 0.176990783274449 bayes_pls_golite062009
GTPase binding 0.0887270623721197 bayes_pls_golite062009
transcription factor activity 0.0408283656118 bayes_pls_golite062009
small GTPase binding 0.0268749201897704 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [156-454]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRRGTGRSDE NDDDLQRAIS ASRLTAEEDE RRRKQDEDYE TALQLSKEEE ELKRLQDLQR  60
   61 MQQQQGQQQL QQPMYYDIFG NPITPEEYAQ FQLQQQQQQQ QQQLQQQPMY YDVFGNPITP 120
  121 EELAQFQQQQ QLQEQQYLAS MQQQQQAMSN NPFAKSEQSS SSPKRNQLVA ASSPQQLQQQ 180
  181 KQQEPLIQNR TGNQSMTDKY SKLNELLATG TGIDTFGNVG EARIPAQHTK TGTFINSQGT 240
  241 GYRQVSDDPN HNPFLNSQYT GLPSTSVVPT QTGYGFGNQS QQQSQNNGSN NRGYTLIDL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [280-454]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFQQQQQLQE QQYLASMQQQ QQAMSNNPFA KSEQSSSSPK RNQLVAASSP QQLQQQKQQE  60
   61 PLIQNRTGNQ SMTDKYSKLN ELLATGTGID TFGNVGEARI PAQHTKTGTF INSQGTGYRQ 120
  121 VSDDPNHNPF LNSQYTGLPS TSVVPTQTGY GFGNQSQQQS QNNGSNNRGY TLIDL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle