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Protein Overview: MRK1

General Information:
Name(s) found: MRK1 / YDL079C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 501 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: regulation of protein catabolic process [IGILink to PubMed article]
    protein amino acid phosphorylation [IGILink to PubMed article][ISSLink to PubMed article]
    response to stress [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: glycogen synthase kinase 3 activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDVLRSLVR KISFNNSDNL QLKHKTSIQS NTALEKKKRK PDTIKKVSDV QVHHTVPNFN  60
   61 NSSEYINDIE NLIISKLIDG GKEGIAVDHI EHANISDSKT DGKVANKHEN ISSKLSKEKV 120
  121 EKMINFDYRY IKTKERTIHK RVYKHDRKTD VDRKNHGGTI DISYPTTEVV GHGSFGVVVT 180
  181 TVIIETNQKV AIKKVLQDRR YKNRELETMK MLCHPNTVGL QYYFYEKDEE DEVYLNLVLD 240
  241 YMPQSLYQRL RHFVNLKMQM PRVEIKFYAY QLFKALNYLH NVPRICHRDI KPQNLLVDPT 300
  301 TFSFKICDFG SAKCLKPDQP NVSYICSRYY RAPELMFGAT NYSNQVDVWS SACVIAELLL 360
  361 GKPLFSGESG IDQLVEIIKI MGIPTKDEIS GMNPNYEDHV FPNIKPITLA EIFKAEDPDT 420
  421 LDLLTKTLKY HPCERLVPLQ CLLSSYFDET KRCDTDTYVK AQNLRIFDFD VETELGHVPL 480
  481 VERPAIEERL KHFVSAPSSS L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] deduced N/A No confident structure predictions are available.
    2 View Details [91..241] PSI-BLAST 1073.9897 Glycogen synthase kinase-3 beta (Gsk3b)
    3 View Details [242..501] PSI-BLAST 1073.9897 Glycogen synthase kinase-3 beta (Gsk3b)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.68265749805481 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • structural molecule activity
    		•  3.82327979736517 bayes_pls_golite062009
  • MAP kinase 2 activity
    		•  3.27009208121248 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.41610417530517 bayes_pls_golite062009
  • histone kinase activity (H3-S10 specific)
    		•  2.30449166929476 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  2.19834311533772 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.93176092222748 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.90354666768303 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • signal transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.71452519680794 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.68012041942855 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.45392497707807 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.4045088027491 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.4045088027491 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.27184436658773 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.2662335835562 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.16995153203536 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.0383359654359 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  1.03605423743048 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.913893847407112 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • receptor activity
    		•  0.775180603313375 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.728917900114111 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.705634826374884 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.705634826374884 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.705067960165986 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.666159109886349 bayes_pls_golite062009
  • activin binding
    		•  0.664317770352101 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • activin receptor activity
    		•  0.558143200755109 bayes_pls_golite062009
  • cyclin-dependent protein kinase activating kinase activity
    		•  0.529121666062889 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.505233004492768 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.470448662251808 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.406297251827056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • potassium channel regulator activity
    		•  0.359831178301818 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  0.330635248803668 bayes_pls_golite062009
  • ephrin receptor activity
    		•  0.320275111520979 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • RNA binding
    		•  0.245748631571068 bayes_pls_golite062009
  • cation channel activity
    		•  0.245400615103891 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.240883589532225 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • growth factor binding
    		•  0.153144089598532 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.114318824149111 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle