Protein Overview: AGP2

General Information:
Name(s) found:	AGP2 / YBR132C [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease [SGD]
Organism:	Saccharomyces cerevisiae
Length:	596 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [IDA] integral to plasma membrane [IDA] vacuolar membrane [IDA]
Biological Process:	response to osmotic stress [IDA] telomere maintenance [IMP] polyamine transport [IMP] carnitine transport [IDA] amino acid transport [IMP] fatty acid metabolic process [IDA]
Molecular Function:	polyamine transmembrane transporter activity [IMP] amino acid transmembrane transporter activity [IMP] carnitine transporter activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKERMTIDY ENDGDFEYDK NKYKTITTRI KSIEPSEGWL EPSGSVGHIN TIPEAGDVHV  60
   61 DEHEDRGSSI DDDSRTYLLY FTETRRKLEN RHVQLIAISG VIGTALFVAI GKALYRGGPA 120
  121 SLLLAFALWC VPILCITVST AEMVCFFPVS SPFLRLATKC VDDSLAVMAS WNFWFLECVQ 180
  181 IPFEIVSVNT IIHYWRDDYS AGIPLAVQVV LYLLISICAV KYYGEMEFWL ASFKIILALG 240
  241 LFTFTFITML GGNPEHDRYG FRNYGESPFK KYFPDGNDVG KSSGYFQGFL ACLIQASFTI 300
  301 AGGEYISMLA GEVKRPRKVL PKAFKQVFVR LTFLFLGSCL CVGIVCSPND PDLTAAINEA 360
  361 RPGAGSSPYV IAMNNLKIRI LPDIVNIALI TAAFSAGNAY TYCSSRTFYG MALDGYAPKI 420
  421 FTRCNRHGVP IYSVAISLVW ALVSLLQLNS NSAVVLNWLI NLITASQLIN FVVLCIVYLF 480
  481 FRRAYHVQQD SLPKLPFRSW GQPYTAIIGL VSCSAMILIQ GYTVFFPKLW NTQDFLFSYL 540
  541 MVFINIGIYV GYKFIWKRGK DHFKNPHEID FSKELTEIEN HEIESSFEKF QYYSKA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		AGP2 AGP3 AVT3 AVT4 AVT6 BPT1 CAN1 DIP5 GAP1 LEU5 MCH5 MMP1 MUP1 PET8 SAM3 THI7 TNA1 TPN1 TPO1 TPO3 TPO4 VBA1 VBA2 VHT1 YEA6 YET3 ZRT1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC40	AGP2	1	Unpublished Fields Lab Data
View Screen	HMT1	AGP2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	AGP2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..69]	deduced	N/A	No confident structure predictions are available.
2	View Details	[70..596]	Pfam	251.327902	Amino acid permease No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2