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Protein Overview: VHT1

General Information:
Name(s) found: VHT1 / YGR065C [SGD]
Description(s) found:
Found 25 descriptions.
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  • High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 593 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: biotin transport [IDALink to PubMed article]
    Molecular Function: biotin transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTISNKSWRS YFPHLRKLPE DDQYLYSDDT NSSIIAEEEL HHSVDKSSKT DVTAETTAVE  60
   61 PHPHNLRHDL PYEVRDEAGR KWWKYFDEFE YRVNKEYKKS RKWYEFLYPN HTTQTKAERR 120
  121 LLYKLDIIIA LYFFMLCWSK SVDLNNYTNA YVSNMKEDLN MKGNDYVYTS TIANVGAIVF 180
  181 QLPFMYLLPR FPSHIILPVM DLGWTWFTFA CYRANSLAEL RAYRFILSAF GAAYYPVSQY 240
  241 ILGCWYAPDE INSRVCLFFC GQQLGSVTSG LLQSRIFKSL NGVHGLAGWR WMFLIDAIAI 300
  301 SLPTAIIGFF VIPGVPSKCY SLFLTDEEIR IARARNKRNQ IKDGVDKSKL APLWSRKLWK 360
  361 KVFCTPAFWV LVVFDTCSWN NMTAYSGSYT LWLKSNTKYS IAQVNNLSVI PACLGFAYVI 420
  421 FCAFGADLFR CKWIFMVFAA IMNTVSCALL IKWDIPSKAK WYAFFTTYFS VAASPCLWSF 480
  481 INDFLRFDPQ VKAITWIAIY SFSQSTYAWI PTLAWPTVES PRFKTGYTVS LIFGAIYGLW 540
  541 TFVVLFFYKR NEKKHALGNG IILYDSNKGE ELPEFVKKNM EERDGYYYLK RSS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) AGP2 BIO5 MCH5 THI7 VHT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VHT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] deduced N/A No confident structure predictions are available.
    2 View Details [65..593] PSI-BLAST 51.221849 No description for 1ja5A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  5.46247398538901 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.58978526526921 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.94605227012838 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.88180006470231 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  2.52916479889426 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • binding
    		•  0.873217664940684 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  0.312628600969375 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle