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Protein Overview: THI7

General Information:
Name(s) found: THI7 / YLR237W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 598 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: thiamin transport [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: thiamin transmembrane transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFGSKVSRA LRFLEIPVKD RASVSFLKNP DLQPIKSANQ TWGFWSNFAY WGVMSFSVGT  60
   61 WMSASSALGV GLSYPETIGT FIVGDVLTII FTLANSCPGY DWKVGFTLAQ RFVFGIYGSA 120
  121 FGIIIRILMS IVNYGSNAWV GGLCINMILD SWSHHYLHLP NTLSSKVAMT TKELIGFIIF 180
  181 HVLTAFCYLM KPYHMNYILI WSCVATFFSM LGMVIYLAKQ AHGVGELFTS TKSTATGSTK 240
  241 AWAWVYMISY WFGSVSPGST NQSDYSRFGS SNWAIWAGTI CALLIPTTLI PVFGVIGAST 300
  301 CDKLYGEQYW MPMDIFNHWL TTNYSAGARA GAFFCGLSFV LSQMSYTISN CGFASGMDLA 360
  361 GLLPKYVDIK RGALFAACVS WACLPWNFYN SSSTFLTVMS SFGVVMTPII SVMICDNFLI 420
  421 RKRQYSITNA FILKGEYYFT KGVNWRAIVA WVCGMTPGLP GIAWEVNNDY FHNTGIVNFF 480
  481 YGDSFFSFLI SFFVYWGLCL LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI 540
  541 RAYTLGEGYT TGHEYRPEGS DDEIPELVKT SSENTNEFEI VHHKNNEKQS STASEKAA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) AGP2 BIO5 FEN2 MCH5 THI7 VHT1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data THI7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..546] Pfam 179.017729 Permease for cytosine/purines, uracil, thiamine, allantoin No confident structure predictions are available.
    2 View Details [547..598] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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