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Protein Overview: BIO5

General Information:
Name(s) found: BIO5 / YNR056C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 561 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISSLink to PubMed article]
    Biological Process: biotin biosynthetic process [IMPLink to PubMed article]
    vitamin transport [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: surfactant activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRVGAVFLF VYERNFFLSI VPDRHRTEIR MSSSERSEVK FDKHFNWWSL LGIAFSLSCS  60
   61 WVGISASMAV GIASGGPLLI IYGLIIAAFF SLMCGISLGD FAAILPNSSG GSFWVLKMLE 120
  121 QESVTLKTPE YEDPSDDDEE VFLENYCQTF NVEVSSKFQK VSSMVVGLLN YFGAIFTTAS 180
  181 ICSSLSMSCI GIHKLLHPDY ELKHWHVFVG YECINAVLTL FNIYSTPLPY ISQFGLYTSL 240
  241 LSFAMTFIIC IVSRSDNTVD PWPKASNIFG SFDNQTGWNS SGMAFVVGLV NPIWAFVGID 300
  301 SATHMIDEVG YSKSRFLVPK VIITTIIVGF VTSFIYCVGL FFCITDQTAV VESILPIVEI 360
  361 FYQATGNRNL SVFLQCMCIT TGFVSGIASG TWQSRILQSF GKSYAPFYKE GSLGNKSLKK 420
  421 LAVLTPGFKS PLYAHFLSQI CVTIIGCIFM GSSTAFNAII TACITLLLMS YAVPSFIFLF 480
  481 VIKKEKFIHR IESDVNCVSR PNRRRMSMIP HIICILWTLF CLVFLSFPYT LPVTAGNMNY 540
  541 TSVVYAVVFC IISIVVFPTC I

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) BIO5 MCH5 THI7 VHT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BIO5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] MSA 8.509997 View MSA. No confident structure predictions are available.
    2 View Details [155..279] deduced N/A No confident structure predictions are available.
    3 View Details [280..561] MSA 10.526994 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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