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Protein Overview: MCH5

General Information:
Name(s) found: MCH5 / YOR306C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 521 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: riboflavin transport [IGILink to PubMed article]
    Molecular Function: riboflavin transporter activity [IGILink to PubMed article]
    [NOT]monocarboxylic acid transmembrane transporter activity [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDSLTPKD TIVPEEQTNQ LRQPDLDEDS IHYDPEADDL ESLETTASYA STSVSAKVYT  60
   61 KKEVNKGTDI ESQPHWGENT SSTHDSDKEE DSNEEIESFP EGGFKAWVVT FGCFLGLIAC 120
  121 FGLLNSTGVI ESHLQDNQLS SESVSTIGWL FSLFLFVCSA SCIISGTYFD RNGFRTIMIV 180
  181 GTVFHVAGLF ATANSTKYWH FILSFAIVCG FGNGIVLSPL VSVPAHYFFK RRGTALAMAT 240
  241 IGGSVGGVVF PIMLRSFFSM KSDTDPTYGF VWGIRTLGFL DLALLTLSII LVKERLPHVI 300
  301 ENSKDGESRW RYILRVYILQ CFDAKAFLDM KYLFCVLGTV FSELSINSAL TYYGSYATSH 360
  361 GISANDAYTL IMIINVCGIP GRWVPGYLSD KFGRFNVAIA TLLTLFIVMF VGWLPFGTNL 420
  421 TNMYVISALY GFCSGSVFSL LPVCCGQISK TEEFGKRYST MYFVVGFGTL VGIPITGAII 480
  481 SIKTTADYQH YIIFSGLATF VSAVCYIISR AYCVGFKWVR F

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) AGP2 BIO5 MCH5 THI7 TPN1 VHT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] deduced N/A No confident structure predictions are available.
    2 View Details [83..521] Pfam 3.070581 Sugar (and other) transporter No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.3426261924492 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.29689809004391 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.15783210522667 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.94035843948137 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.5181741634556 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • binding
    		•  0.873217664940684 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle