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Protein Overview: src-1

General Information:
Name(s) found: src-1 / CE39993 [WormBase]
Description(s) found:
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  • WBGene00005077 locus:src-1 status:Confirmed UniProt:G5EE56 protein_id:CCD71465.1 [WormBase]
  • gi|89179499|gb|AAK29735.4| Src oncogene related protein 1 [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_490866.2| SRC oncogene related (60.7 kD) (src-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|23393797|gb|AAN31394.1|AF419171_1 protein tyrosine kinase [Caenorhabditis elegans] [NCBI NR]
  • gi|19072780|gb|AAL84635.1|AF475094_1 SRC-1 [Caenorhabditis elegans] [NCBI NR]
  • gi|115533600|ref|NP_490866.4| SRC oncogene related family member (src-1) [Caenorhabditis elegans] [NCBI NR]
  • Tyrosine protein-kinase src-1 OS=Caenorhabditis elegans GN=src-1 PE=1 SV=1 [Swiss-Prot]
  • SRC oncogene related (60.7 kD) (src-1) [Caenorhabditis elegans]gi|23393797|gb|AAN31394.1| protein tyrosine kinase [Caenorhabditis elegans]gi|19072780|gb|AAL84635.1| SRC-1 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE39993 WBGene00005077 locus:src-1 status:Confirmed UniProt:Q8T6F8_CAEEL protein_id:AAK29735.4 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE39993 WBGene00005077 locus:src-1 status:Confirmed UniProt:Q8T6F8_CAEEL protein_id:AAK29735.4| [wormORF-contam.fasta]
  • CE39993 WBGene00005077 locus:src-1 status:Confirmed TR:Q8T6F8 protein_id:AAK29735.4 [wormpep160-contam.fasta]
  • protein tyrosine kinase [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • SRC oncogene related family member (src-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Src oncogene related protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • SRC-1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE39993 WBGene00005077 locus:src-1 status:Confirmed UniProt:Q8T6F8 protein_id:AAK29735.4 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE39993 WBGene00005077 locus:src-1 status:Confirmed UniProt:G5EE56 protein_id:CCD71465.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE39993 WBGene00005077 locus:src-1 status:Confirmed UniProt:G5EE56 protein_id:CCD71465.1 Non-specific protein-tyrosine kinase [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 533 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: embryonic cleavage [IMPLink to PubMed article]
    spindle organization [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    gonad development [IMPLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCLFSKERR SGGSDMGVSE RIDVSRFQTP QQQTVFHVNN GGNEGTISQL NGTSDGMMGN  60
   61 GRGGGGGGGA QERETLVALY PYDSRADGDL SFQKGDAMYL LDHSNCDWWY VRHQRTGQTG 120
  121 YVPRNFVAKQ QTIESEEWYA GKIPRNRAER LVLSSHLPKG TFLIREREAD TREFALTIRD 180
  181 TDDQRNGGTV KHYKIKRLDH DQGYFITTRR TFRSLQELVR YYSDVPDGLC CQLTFPAPRL 240
  241 APTRPDLSHD TQQNWEIPRN QLHLKRKLGD GNFGEVWYGK WRGIVEVAIK TMKPGTMSPE 300
  301 AFLQEAQIMK QCDHPNLVKL YAVCTREEPF YIITEYMING SLLQYLRTDG STLGIQALVD 360
  361 MAAQIANGMM YLEERKLVHR DLAARNVLVG DKISGVPVVK VADFGLARKL MEEDIYEART 420
  421 GAKFPIKWTA PEAATCGNFT VKSDVWSYGI LLYEIMTKGQ VPYPGMHNRE VVEQVELGYR 480
  481 MPMPRGCPEQ IYEEVLLKCW DKTPDRRPTF DTLYHFFDDY FVSTQPNYAP PSA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..533] PSI-BLAST 120.0 No description for 2h8hA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • CD8 receptor binding
    		•  4.05356115367695 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • erythropoietin receptor binding
    		•  3.89714169376776 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • PTB domain binding
    		•  3.37370070512378 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  3.26784640416242 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • SH2 domain binding
    		•  3.03401803018883 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.52273333081659 bayes_pls_golite062009
  • insulin receptor activity
    		•  2.48320803030481 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  2.18795259566024 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  2.1677218320705 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  2.1677218320705 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • insulin binding
    		•  2.0719180171079 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  1.93826393981131 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • amine binding
    		•  1.88718396958192 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.55071552871145 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • cation channel activity
    		•  1.38878809769275 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • activin binding
    		•  1.22461306010416 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.06651320735249 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  1.03150090191995 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • channel activity
    		•  0.958702913594936 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.958702913594936 bayes_pls_golite062009
  • ion channel activity
    		•  0.935000804348868 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.934955860431071 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.880236579821909 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  0.856861384729301 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • activin receptor activity
    		•  0.811117252475389 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.794058505655489 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.775404673285876 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • DNA binding
    		•  0.714163549867672 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.705067960165986 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • Janus kinase activity
    		•  0.580310109637219 bayes_pls_golite062009
  • transcription factor activity
    		•  0.563262875317016 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.546647574638943 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.53226085423174 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.505233004492768 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.487555922788887 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • transcription activator activity
    		•  0.481994471237116 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • acetylcholine receptor regulator activity
    		•  0.245880889705531 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.240883589532225 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  0.117759584117941 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.0613131034808199 bayes_pls_golite062009
  • cation binding
    		•  0.046173055856133 bayes_pls_golite062009
  • metal ion binding
    		•  0.046173055856133 bayes_pls_golite062009
  • ion binding
    		•  0.0389662058697694 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle