| Protein: | Akt1-PC |
| Organism: | Drosophila melanogaster |
| Length: | 611 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Akt1-PC.
| Description | E-value | Query Range |
Subject Range |
|
|
567.0 | [0..1] | [611..1] |
|
Region A: Residues: [1-89] |
1 11 21 31 41 51
| | | | | |
1 MNYLPFVLQR RSTVVASAPA PGSASRIPES PTTTGSNIIN IIYSQSTHPN SSPTSGSAEK 60
61 FSWQQSWPSR TSAAPTHDSG TMSINTTFD
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [90-254] |
1 11 21 31 41 51
| | | | | |
1 LSSPSVTSGH ALTEQTQVVK EGWLMKRGEH IKNWRQRYFV LHSDGRLMGY RSKPADSAST 60
61 PSDFLLNNFT VRGCQIMTVD RPKPFTFIIR GLQWTTVIER TFAVESELER QQWTEAIRNV 120
121 SSRLIDVGEV AMTPSEQTDM TDVDMATIAE DELSEQFSVQ GTTCN
|
| Detection Method: | |
| Confidence: | 17.39794 |
| Match: | 1unpA |
| Description: | Crystal structure of the pleckstrin homology domain of PKB alpha |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| actin binding | 3.72754591832642 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 3.48744511411671 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 3.3707139031954 | bayes_pls_golite062009 |
| binding | 3.29080729281876 | bayes_pls_golite062009 |
| protein binding | 3.17213698546013 | bayes_pls_golite062009 |
| insulin receptor binding | 2.87341016128079 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.84482185829578 | bayes_pls_golite062009 |
| profilin binding | 2.77241328262501 | bayes_pls_golite062009 |
| actin filament binding | 2.03444575838575 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.8384977631304 | bayes_pls_golite062009 |
| transcription regulator activity | 1.70142823077711 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase signaling protein activity | 1.56969272757764 | bayes_pls_golite062009 |
| signal transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| molecular transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| structural molecule activity | 1.54100420420988 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.53043443218632 | bayes_pls_golite062009 |
| kinase activity | 1.49733072352288 | bayes_pls_golite062009 |
| nucleic acid binding | 1.45333553095537 | bayes_pls_golite062009 |
| DNA binding | 1.44750105267972 | bayes_pls_golite062009 |
| SH2 domain binding | 1.41526564231882 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.36365892826676 | bayes_pls_golite062009 |
| protein kinase activity | 1.34246406302496 | bayes_pls_golite062009 |
| transporter activity | 1.28986800087234 | bayes_pls_golite062009 |
| receptor activity | 1.1755016270537 | bayes_pls_golite062009 |
| enzyme binding | 1.17212675145623 | bayes_pls_golite062009 |
| phosphatidylinositol-3,4-bisphosphate binding | 1.15025513961661 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.1152029796159 | bayes_pls_golite062009 |
| phospholipid binding | 1.09683218092034 | bayes_pls_golite062009 |
| Ran GTPase binding | 1.07023555877478 | bayes_pls_golite062009 |
| transferase activity | 1.05502123133116 | bayes_pls_golite062009 |
| receptor binding | 1.00859318603128 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.00400540041137 | bayes_pls_golite062009 |
| kinase binding | 0.961706066143 | bayes_pls_golite062009 |
| protein domain specific binding | 0.90578029954417 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.79883446648737 | bayes_pls_golite062009 |
| phosphoinositide binding | 0.71817045430443 | bayes_pls_golite062009 |
| protein kinase binding | 0.67284191028382 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.611829373978789 | bayes_pls_golite062009 |
| protein complex binding | 0.55916857709427 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase docking protein activity | 0.47238283185104 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.470521479239198 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.391864697086635 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.355387992614734 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.35466574267734 | bayes_pls_golite062009 |
| hydrolase activity | 0.354215977182915 | bayes_pls_golite062009 |
| beta-amyloid binding | 0.34714857141225 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.335498703113274 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.189879136353541 | bayes_pls_golite062009 |
| G-protein-coupled receptor binding | 0.12466518799375 | bayes_pls_golite062009 |
| alpha-catenin binding | 0.102004310679969 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.0611639610381174 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.0524559849408587 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.0498422520006935 | bayes_pls_golite062009 |
|
Region A: Residues: [255-526] |
1 11 21 31 41 51
| | | | | |
1 SSGVKKVTLE NFEFLKVLGK GTFGKVILCR EKATAKLYAI KILKKEVIIQ KDEVAHTLTE 60
61 SRVLKSTNHP FLISLKYSFQ TNDRLCFVMQ YVNGGELFWH LSHERIFTED RTRFYGAEII 120
121 SALGYLHSQG IIYRDLKLEN LLLDKDGHIK VADFGLCKED ITYGRTTKTF CGTPEYLAPE 180
181 VLDDNDYGQA VDWWGTGVVM YEMICGRLPF YNRDHDVLFT LILVEEVKFP RNITDEAKNL 240
241 LAGLLAKDPK KRLGGGKDDV KEIQAHPFFA SI
|
| Detection Method: | |
| Confidence: | 68.69897 |
| Match: | 1z5mA |
| Description: | Crystal Structure Of N1-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethylpropanediamide Complexed with Human PDK1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| cyclic nucleotide-dependent protein kinase activity | 4.97855712164511 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| cAMP-dependent protein kinase activity | 4.66277812893755 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.79505438761262 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.59526003830791 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.52531786618214 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.46424348876434 | bayes_pls_golite062009 |
| signal transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| molecular transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| receptor activity | 2.39311927684508 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.37122853419919 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 2.29961206600837 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.12615078788254 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 2.11281448162259 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 1.94085498993561 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.9016235206634 | bayes_pls_golite062009 |
| actin binding | 1.87817875565699 | bayes_pls_golite062009 |
| acetylcholine receptor activator activity | 1.83545227594542 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 1.74206248731815 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 1.55257528159541 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase activity | 1.5013287968167 | bayes_pls_golite062009 |
| 1-phosphatidylinositol-3-kinase activity | 1.43713739644553 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| PTB domain binding | 1.33588583294761 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.32254739984688 | bayes_pls_golite062009 |
| kinase binding | 1.26086833316556 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 1.25765701903393 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 1.2266791546014 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transcription regulator activity | 1.16307073947901 | bayes_pls_golite062009 |
| type II transforming growth factor beta receptor binding | 1.15601343883601 | bayes_pls_golite062009 |
| tubulin binding | 1.13686658158825 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| structural molecule activity | 1.10436308210353 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 1.10045286406485 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 1.10045286406485 | bayes_pls_golite062009 |
| nucleic acid binding | 1.06086848160606 | bayes_pls_golite062009 |
| protein kinase binding | 1.06030596516506 | bayes_pls_golite062009 |
| cation channel activity | 1.04999722123563 | bayes_pls_golite062009 |
| DNA binding | 1.02122968429273 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.959360414036299 | bayes_pls_golite062009 |
| telethonin binding | 0.953133636042811 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| transcription factor activity | 0.825932471558326 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| actin filament binding | 0.794152600084 | bayes_pls_golite062009 |
| platelet-derived growth factor receptor binding | 0.770658204347392 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.75189004129952 | bayes_pls_golite062009 |
| transcription activator activity | 0.746097961522136 | bayes_pls_golite062009 |
| microtubule binding | 0.734274677384472 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.612883428421652 | bayes_pls_golite062009 |
| insulin receptor activity | 0.585036697436369 | bayes_pls_golite062009 |
| transcription repressor activity | 0.568332175782799 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 0.547121592096699 | bayes_pls_golite062009 |
| activin binding | 0.510364757301021 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase regulator activity | 0.406297251827056 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| peptide hormone binding | 0.312169974523858 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 0.294256794094724 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 0.287757704969289 | bayes_pls_golite062009 |
| channel activity | 0.287189255116606 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 0.287189255116606 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.261869836686301 | bayes_pls_golite062009 |
| ion channel activity | 0.241519346930618 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| polysaccharide binding | 0.229808864843639 | bayes_pls_golite062009 |
| SH2 domain binding | 0.226760162354251 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| insulin binding | 0.147382876071569 | bayes_pls_golite062009 |
| peptide binding | 0.118578378753757 | bayes_pls_golite062009 |
| alpha-actinin binding | 0.0923798087054641 | bayes_pls_golite062009 |
| JUN kinase kinase kinase activity | 0.0613131034808199 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 0.0506751594607393 | bayes_pls_golite062009 |
| MAP kinase kinase kinase kinase activity | 0.01826424351081 | bayes_pls_golite062009 |
| nitric-oxide synthase regulator activity | 0.00407218246327123 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
|
Region A: Residues: [527-611] |
1 11 21 31 41 51
| | | | | |
1 NWTDLVLKKI PPPFKPQVTS DTDTRYFDKE FTGESVELTP PDPTGPLGSI AEEPLFPQFS 60
61 YQGDMASTLG TSSHISTSTS LASMQ
|
| Detection Method: | |
| Confidence: | 101.0 |
| Match: | 2jdoA |
| Description: | No description for 2jdoA was found. |
